Le conseil post-test encourage-t-il les PVVIH &#224 partager leur statut s&#233rologique? Pratiques et suggestions des conseillers au Burkina Faso

Full Title:Le conseil post-test encourage-t-il les PVVIH à partager leur statut sérologique? Pratiques et suggestions des conseillers au Burkina Faso (Does post-test counseling support PLHIV in disclosing their HIV status? Practices and propositions by counselors in Burkina Faso)Le partage du rèsultat du test VIH est, selon les normes, abordé lors du counseling post-test. Cependant, alors que les obstacles au partage d’un résultat VIH positif sont attestés, la littérature reste peu abondante sur la maniére dont les directives sont appliquées sur le terrain. L’objectif de cet article est d’examiner les pratiques de conseil concernant le partage du résultat avec l’entourage rapportées par les clients et les prestataires du conseil et test VIH (CTV) au Burkina Faso. Une enquête transversale a été conduite en milieu urbain et en milieu rural en 2008. Un questionnaire intégrant des questions semi-ouvertes a été utilisé. Un nombre total de 542 personnes qui ont réalisé le test depuis 2007 et 111 prestataires de services de conseil et test VIH ont été interviewés. Les données ont été analysées sur SPSS 12. Seulement 29 % des personnes testées déclarent que le théme du partage du résultat avec l’entourage a été discuté avec elles lors du counseling post-test. Ce résultat s’explique par les incertitudes et les inquiétudes des prestataires sur la maniére de partager et sur les risques de conséquences défavorables du partage. Des stratégies sont développées par les prestataires pour soutenir les personnes dont la séropositivité a été dépistée à partager cette information avec l’entourage mais ils reconnaissent que ces actions sont insuffisantes. Les suggestions des prestataires pour améliorer la situation incluent la lutte contre la stigmatisation vis-à-vis des personnes vivant avec le VIH, le renforcement des compétences des prestataires et l’adoption de textes juridiques pour rendre obligatoire le partage du résultat avec le partenaire. En conclusion, l’étude a identifié plusieurs pistes pour améliorer les pratiques de conseil concernant le partage des résultats au Burkina Faso. Ces observations pourraient avoir une portée globale pour la région Afrique.Mots cle´: partage résultat VIH, rôle des prestataires, conseil post-test, MATCH, Burkina Fas

Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation.

Immune abnormalities have been described in some individuals with autism spectrum disorders (ASDs) as well as their family members. However, few studies have directly investigated the role of prenatal cytokine and chemokine profiles on neurodevelopmental outcomes in humans. In the current study, we characterized mid-gestational serum profiles of 22 cytokines and chemokines in mothers of children with ASD (N=415), developmental delay (DD) without ASD (N=188), and general population (GP) controls (N=428) using a bead-based multiplex technology. The ASD group was further divided into those with intellectual disabilities (developmental/cognitive and adaptive composite score<70) (ASD+ID, N=184) and those without (composite score⩾70) (ASD-noID, N=201). Levels of cytokines and chemokines were compared between groups using multivariate logistic regression analyses, adjusting for maternal age, ethnicity, birth country and weight, as well as infant gender, birth year and birth month. Mothers of children with ASD+ID had significantly elevated mid-gestational levels of numerous cytokines and chemokines, such as granulocyte macrophage colony-stimulating factor, interferon-γ, interleukin-1α (IL-1α) and IL-6, compared with mothers of children with either ASD-noID, those with DD, or GP controls. Conversely, mothers of children with either ASD-noID or with DD had significantly lower levels of the chemokines IL-8 and monocyte chemotactic protein-1 compared with mothers of GP controls. This observed immunologic distinction between mothers of children with ASD+ID from mothers of children with ASD-noID or DD suggests that the intellectual disability associated with ASD might be etiologically distinct from DD without ASD. These findings contribute to the ongoing efforts toward identification of early biological markers specific to subphenotypes of ASD

EuroGammaS gamma characterisation system for ELI-NP-GBS: The nuclear resonance scattering technique

A Gamma Beam Characterisation System has been designed by the EuroGammaS association for thecommissioning and development of the Extreme Light Infrastructure-Nuclear Physics Gamma Beam System(ELI-NP-GBS) to be installed in Magurele, Romania. The characterisation system consists of four elements: aCompton spectrometer, a sampling calorimeter, a nuclear resonant scattering spectrometer (NRSS) and a beamprofile imager. In this paper, the nuclear resonant scattering spectrometer system, designed to perform anabsolute energy calibration for the gamma beam, will be describe

Neuronal Metabolism and Neuroprotection: Neuroprotective Effect of Fingolimod on Menadione-Induced Mitochondrial Damage

Imbalance in the oxidative status in neurons, along with mitochondrial damage, are common characteristics in some neurodegenerative diseases. The maintenance in energy production is crucial to face and recover from oxidative damage, and the preservation of different sources of energy production is essential to preserve neuronal function. Fingolimod phosphate is a drug with neuroprotective and antioxidant actions, used in the treatment of multiple sclerosis. This work was performed in a model of oxidative damage on neuronal cell cultures exposed to menadione in the presence or absence of fingolimod phosphate. We studied the mitochondrial function, antioxidant enzymes, protein nitrosylation, and several pathways related with glucose metabolism and glycolytic and pentose phosphate in neuronal cells cultures. Our results showed that menadione produces a decrease in mitochondrial function, an imbalance in antioxidant enzymes, and an increase in nitrosylated proteins with a decrease in glycolysis and glucose-6-phosphate dehydrogenase. All these effects were counteracted when fingolimod phosphate was present in the incubation media. These effects were mediated, at least in part, by the interaction of this drug with its specific S1P receptors. These actions would make this drug a potential tool in the treatment of neurodegenerative processes, either to slow progression or alleviate symptoms

Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development

Numerous studies have reported immune system disturbances in individuals with autism and their family members; however, there is considerable variability in findings with respect to the specific immune conditions involved, their timing, and the family members affected and little understanding of variation by autism subphenotype. Using data from the Study to Explore Early Development (SEED), a multi-site case-control study of children born 2003–2006 in the United States, we examined the role of family history of autoimmune diseases, asthma, and allergies in autism spectrum disorder (ASD) as well as other developmental disorders (DD). We investigated maternal immune conditions during the pregnancy period, as well as lifetime history of these conditions in several family members (mother, father, siblings, and study child). Logistic regression analyses included 663 children with ASD, 984 children with DD, and 915 controls ascertained from the general population (POP). Maternal history of eczema/psoriasis and asthma was associated with a 20%–40% increased odds of both ASD and DD. Risk estimates varied by specific ASD subphenotypes in association with these exposures. In addition, children with ASD were more likely to have a history of psoriasis/eczema or allergies than POP controls. No association was observed for paternal history or family history of these immune conditions for either ASD or DD. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes, and further suggest that associations may differ by ASD phenotype of the child. Autism Research 2019, 12: 123–135. © 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary: Using data from a large multi-site study in the US—the Study to Explore Early Development—we found that women with a history of eczema/psoriasis and asthma are more likely to have children with ASD or DD. In addition, children with ASD are more likely to have a history of psoriasis/eczema or allergies than typically developing children. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes

CALOCUBE: An approach to high-granularity and homogenous calorimetry for space based detectors

Future space experiments dedicated to the observation of high-energy gamma and cosmic rays will increasingly rely on a highly performing calorimetry apparatus, and their physics performance will be primarily determined by the geometrical dimensions and the energy resolution of the calorimeter deployed. Thus it is extremely important to optimize its geometrical acceptance, the granularity, and its absorption depth for the measurement of the particle energy with respect to the total mass of the apparatus which is the most important constraint for a space launch. The proposed design tries to satisfy these criteria while staying within a total mass budget of about 1.6 tons. Calocube is a homogeneous calorimeter instrumented with Cesium iodide (CsI) crystals, whose geometry is cubic and isotropic, so as to detect particles arriving from every direction in space, thus maximizing the acceptance; granularity is obtained by filling the cubic volume with small cubic CsI crystals. The total radiation length in any direction is more than adequate for optimal electromagnetic particle identification and energy measurement, whilst the interaction length is at least sufficient to allow a precise reconstruction of hadronic showers. Optimal values for the size of the crystals and spacing among them have been studied. The design forms the basis of a three-year R&D activity which has been approved and financed by INFN. An overall description of the system, as well as results from preliminary tests on particle beams will be described