Efficacy and Safety of Clearing Heat and Detoxifying Injection in the Treatment of Influenza: A Randomized, Double-Blinded, Placebo-Controlled Trial

Objective. To evaluate the efficacy and safety of CHDI in the treatment of influenza infection. Method. A randomized double-blind, double dummy trial was conducted. Influenza patients with a positive influenza A rapid test diagnosis were randomized to receive CHDI or oseltamivir. Primary outcome was assessed by the median fever alleviation time and clearance time, and secondary outcome was total scores of influenza symptoms. Results. One hundred thirty-nine participants were screened and 34 had a RT-PCR laboratory confirmation of influenza virus infection. Fever alleviation time was 2.5 and 5 hours in CHDI and oseltamivir, respectively, and fever clearance time was 32.5 and 49 hours. The HR of fever alleviation and clearance time shows no significant difference between two groups. Total scores of influenza symptoms descended significantly in both groups after treatment and descended more in CHDI than oseltamivir on day 2. Similar to total symptoms severity score, fever severity score descend more significantly in CHDI than oseltamivir on day 2, and there were no differences on other symptoms. Conclusions. CHDI have a similar effect to oseltamivir in reducing the duration of influenza illness. CHDI was well tolerated, with no serious adverse events noted during the study period

Four new species of the trapdoor spider genus Conothele Thorell, 1878 (Araneae, Halonoproctidae) from China

Herein four species of the trapdoor spider genus Conothele Thorell, 1878 collected from China are described as new to science based on the female genital morphology: C. baisha sp. n. (Hainan Province), C. baoting sp. n. (Hainan Province), C. linzhi sp. n. (Tibet), and C. jinggangshan sp. n. (Jiangxi Province). For two Hainan species, C. baisha sp. n. and C. baoting sp. n., between which it is difficult to distinguish solely based on female genital morphology, additional diagnoses derived from species-specific nucleotide substitution information and genetic distances using the mitochondrial gene, cytochrome c oxidase subunit I are provided

Human-centred AI design methods to understand intelligent systems design empowered by multisensory experience with textiles

Conceiving intelligent systems with human-robot interaction is difficult without first-hand knowledge of design tasks. This poster presents ideation results from a workshopon new forms of human-robotic collaboration primed with human experience of multisensory experiences with textiles. Twenty-five Intelligent System Design students were presented with traditional and contemporary design methods regarding the human experience of textiles, along with the latest research in AI and robotic evaluation of multisensory textile properties. Putting theory into practise, participants then engaged in individual tactile subjective assessments of a selection of fabrics with paper-based bipolar scales followed by group reflection on the process. This led into the brainstorming portion of the workshop with the prompt — How can AI collaboration in material assessments advance the applications intertwining with material tangibility? In order to have a range of ideations - participants voted on application domains and self-organised into groups with specific application focuses. The domains were (in order of popularity) – (1) Well-being and Care, (2) Gaming / Metaverse, (3) Craft, (4) Mobility Design and (5) Product Design. This poster presents a collection of ideas centred around these domains produced by the groups. The practical implications of this workshop was to demonstrate how a human-centred design process focused on multisensory experiences presented in theory and then through tactile practise can contribute towards ideation within intelligent systems design

Four new species of the trapdoor spider genus Conothele Thorell, 1878 from Mainland China and Laos (Araneae, Ctenizidae)

Here for the first time the presence of the trapdoor spider genus Conothele Thorell, 1878 (Araneae: Ctenizidae) is reported from mainland China and Laos. Four Conothele species collected from the regions are described as new to science, based on the female genital morphology: C. baiyunensis Xu, Xu & Liu, sp. n. (Guangdong Province), C. daxinensis Xu, Xu & Li, sp. n. (Guangxi Province), C. sidiechongensis Xu, Xu & Liu, sp. n. (Yunnan Province, China and Vietnam), C. yundingensis Xu, Xu & Li, sp. n. (Yunnan Province)

Four new species of the trapdoor spider genus Conothele Thorell, 1878 from Mainland China and Laos (Araneae, Ctenizidae)

10.3897/zookeys.643.10543ZOOKEYS201764363-7

Transient non-Fourier thermal interactions of two parallel cracks in porous metal foam

Experimental evidence shows heat conduction in the porous media would be non-Fourier under specific circumstances. The novelty of this research lies in considerations of the non-Fourier effect and the interactions of two parallel thermally insulated cracks in the porous metal foam. The transient propagation characteristics are examined by utilizing the Dual-phase-lag model, which incorporates the certain time required to establish local thermal equilibrium between the solid framework and surrounding pores. Fourier transform and Laplace transform are employed to solve the mathematical model simulating a porous strip subjected to abrupt thermal shock. After reducing the problem to two groups of singular integral equations, the transient temperature distributions and heat flux intensity factors are determined with the help of numerical Laplace inversion. Numerical calculations are carried out to evaluate the impacts of crack positions, the relative density, phase lags, and two crack lengths on the thermal characteristics, which would contribute to a thorough understanding of the ultrafast process of porous materials operating in extreme conditions

Three new species of the segmented spider genus Qiongthela (Mesothelae, Liphistiidae) from Hainan Island, China

10.3897/zookeys.1009.57857ZOOKEYS10091009123-13