Investigation of healthy lifestyle behaviors and quality of life in individuals undergoing hematopoietic stem cell transplantation

Objective: This descriptive cross-sectional study aimed to investigate healthy lifestyle behaviors and quality of life in individuals who had undergone hematopoietic stem cell transplantation (HSCT) within the past six months and before. The study was conducted with a descriptive cross-sectional design to investigate healthy lifestyle behaviors and quality of life in survivors undergoing hematopoietic stem cell transplantation in six months and before. Patients and Methods: The population of the study consisted of adults, who underwent hematopoietic stem cell transplantation in six months and before, in a university hospital. The sample consisted of 76 cases who were selected via convivence sampling. The data were collected using a Patient Information Form, the Healthy Lifestyle Behaviors Scale–II (HLBS-II), and the SF-36 Quality of Life Scale (SF-36). Results: The mean scores of the HLBS-II and SF-36 Physical and Mental Components were 134.34 ± 19.81, 49.54 ± 23.27, and 52.95 ±2 1.31, respectively. A statistically significant difference was detected in the HLBS-II total score in terms of educational background and the status of receiving radiotherapy treatment (p<0.05). A score of the SF- 36 Physical Component showed a statistically significant difference in terms of working status, status of receiving radiotherapy treatment, developing complications, and re-hospitalization after discharge (p<0.05). A score of SF-36 Mental Component showed a statistically significant difference in terms of the working status and the status of getting regularly vaccinated after hematopoietic stem cell transplantation (p<0.05). There were weak correlations between the total score of HLBS-II and a score of the SF-36 Physical Component (r=0.273 p<0.017). Conclusions: Consequently, it was concluded that the patients had a moderate level of healthy lifestyle behaviors and poor quality of life in the six months and later after hematopoietic stem cell transplantation

Anticancer and anti-inflammatory effects of tomentosin: Cellular and molecular mechanisms

Tomentosin is a natural compound known for its presence in some medicinal plants of the Asteraceae family such as Inula viscosa. Recent studies have highlighted its anticancer and anti-inflammatory properties. Its anticancer mechanisms are unique and act at different levels ranging from cellular organization to molecular transcriptional factors and epigenetic modifications. Tomentosin’s possession of the modulatory effect on telomerase expression on tumor cell lines has captured the interest of researchers and spurred a more robust study on its anticancer effect. Since inflammation has a close link with cancer disease, this natural compound appears to be a potential cancer-fighting drug. Indeed, its recently demonstrated anti-inflammatory action can be considered as a starting point for its evaluation as an anticancer chemo-preventive agent

Accessory spleen hypertrophy mimicking colon cancer metastasis

Accessory spleen is a congenital form of an ectopic splenic tissue. In this report, we present a case of a patient who was followed with the diagnosis of rectal and sigmoid colon cancer and an accessory spleen hypertrophy, which was thought to be colon cancer metastasis in the left hypochondriac region. After colectomy and splenectomy, accessory spleen that mimics cancer metastasis was diffrentially diagnosed using scintigraphy

Unusual metastases of lung cancer: bulbus oculi and maxillary sinus

Lung adenocarcinoma often makes metastasis to the brain, liver, kidneys, bone, bone marrow and adrenal glands. It can also make metastasis to other parts of the body rarely for example eye, nose, parotid gland and paranasal sinus. We did not encounter with combined ocular bulbus and the maxillary sinus metastases of lung cancer in the accessible literature. In this case report, a patient who was combined ocular bulbus and the maxillary sinus metastases of lung adenocarcinoma will be discussed. Key Words: eye metastases, lung adenocarcinoma, paranasal sinus metastases

Characterization of arils juice and peel decoction of fifteen varieties of punica granatum l.: a focus on anthocyanins, ellagitannins and polysaccharides

Pomegranate is receiving renewed commercial and scientific interest, therefore a deeper knowledge of the chemical composition of the fruits of less studied varieties is required. In this work, juices from arils and decoctions from mesocarp plus exocarp were prepared from fifteen varieties. Samples were submitted to High Performance Liquid Chromatography—Diode Array Detector–Mass Spectrometry, spectrophotometric and colorimetric CIEL* a* b* analyses. Antioxidant, antiradical and metal chelating properties, inhibitory activity against tyrosinase and α-amylase enzymes were also evaluated. All varieties presented the same main phenols; anthocyanins and ellagitannins were widely variable among varieties, with the richest anthocyanin content in the juices from the Wonderful and Soft Seed Maule varieties (approx. 660 mg/L) and the highest ellagitannin content in the peel of the Black variety (approx. 133 mg/g dry matter). A good correlation was shown between the colour hue and the delphinidin/cyanidin ratio in juices (R 2= 0.885). Total polysaccharide yield ranged from 3% to 12% of the peels’ dry weight, with the highest content in the Black variety. Decoctions (24.44–118.50 mg KAE/g) showed better in vitro antioxidant properties and higher inhibitory capacity against tyrosinase than juices (not active-16.56 mg KAE/g); the inhibitory capacity against α-amylase was similar and quite potent for juices and decoctions. Knowledge about the chemical composition of different pomegranate varieties will allow for a more aware use of the different parts of the fruit

Exploring for HPLC-MS/MS profiles and biological activities of different extracts from Allium lycaonicum Siehe ex Hayek from Turkey flora

The present study was designed to determine the phenolic constituents, antioxidant, and enzyme inhibition activities of aerial parts and bulbs of Allium lycaonicum (family Amaryllidaceae). Extracts were prepared by maceration and Soxhlet/infusion using hexane, methanol, and water as extraction solvents. Generally, extracts from the aerial parts showed higher total phenolic and individual components and antioxidant activity than their respective bulb extracts. Maceration with water was the best to extract total phenolic content from the aerial parts (29.00 mg gallic acid equivalents (GAE)/g), while the Soxhlet extraction with hexane (22.29 mg GAE/g) was the best for the bulb. Maceration with methanol recovered the highest total flavonoid content from both the aerial parts (41.95 mg (rutin equivalents (RE)/g) and bulb (1.83 mg RE/g). Polar extracts of aerial parts were characterized by higher abundance of kaempferol-3-glucoside (≤20,624.27 μg/mg), hyperoside (≤19,722.76 μg/g), isoquercitrin (≤17,270.70 μg/g), delphindin-3,5-diglucoside (≤14,625.21 μg/g), and rutin (≤10,901.61 μg/g) than the bulb. Aerial parts’ aqueous extract, prepared by maceration, exerted the highest anti-ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical activity (64.09 mg trolox equivalents (TE)/g), Cu++ (83.03 mg TE/g) and Fe+++ (63.03 mg TE/g) reducing capacity while that prepared by infusion recorded the highest anti-DPPH (2,2-diphenyl-1-picrylhydrazyl) radical (31.70 mg TE/g) and metal chelating (27.66 mg EDTAE/g) activities. The highest total antioxidant activity (1.46 mmol TE/g) was obtained by maceration of the bulb with water. Extracts obtained by organic solvents showed remarkable enzyme inhibition properties against the tested enzymes. Soxhlet extraction of the bulb with hexane and methanol recorded the highest acetylcholinesterase inhibition (4.75 mg galanthamine equivalents (GALAE)/g) and tyrosinase inhibition (139.95 mg kojic acid equivalents/g) activities, respectively. Extracts obtained by maceration of the bulb with methanol and the aerial parts with hexane exerted the highest glucosidase inhibition (3.25 mmol acarbose equivalents/g) and butyrylcholinesterase inhibition (20.99 mg GALAE/g) activities, respectively. These data indicated that A. lycaonicum is a source of bioactive molecules with potential antioxidant and enzyme inhibition properties. Nonetheless, the extracts obtained through various solvents and extraction techniques showed variations in their phytoconstituent composition and biological properties

Optical identification and follow-up observations of SRGA J213151.5+491400 -- a new magnetic cataclysmic variable discovered with SRG Observatory

We report results of optical identification and multi-wavelength study of a new polar-type magnetic cataclysmic variable (MCV), SRGA J213151.5+491400, discovered by Spectrum Roentgen-Gamma ($SRG$) observatory in the course of the all-sky survey. We present optical data from telescopes in Turkey (RTT-150 and T100 at the T\"UBITAK National Observatory), and in Russia (6-m and 1-m at SAO RAS), together with the X-ray data obtained with $ART-XC$ and $eROSITA$ telescopes aboard $SRG$ and the $NICER$ observatory. We detect SRGA J213151.5+491400 in a high state in 2020 (17.9 mag) that decreases about 3 mag into a low state (21 mag) in 2021. We find only one significant period using optical photometric time series analysis which reveals the white dwarf spin/orbital period to be 0.059710(1) days (85.982 min). The long slit spectroscopy in the high state yields a power law continuum increasing towards the blue with a prominent He II line along with the Balmer line emissions with no cyclotron humps; consistent with MCV nature. Doppler Tomography confirms the polar nature revealing ballistic stream accretion along with magnetic stream during the high state. These characteristics show that the new source is a polar-type MCV. $SRG$ $ART-XC$ detections yield an X-ray flux of (4.0-7.0)$\times$10$^{-12}$ erg cm$^2$ s$^{-1}$ in the high state. $eROSITA$ detects a dominating hot plasma component (kT$_{\rm{max}}$ $>$ 21 keV in the high state) declining to (4.0-6.0)$\times$10$^{-13}$ erg cm$^2$ s$^{-1}$ in 2021 (low state). The $NICER$ data obtained in the low state reveal a two-pole accretor showing a soft X-ray component at (6-7)$\sigma$ significance with a blackbody temperature of 15-18 eV. A soft X-ray component has never been detected for a polar in the low state before.Comment: 16 pages, 4 Tables and 15 Figures. Accepted for publication in A&A as it stand

Molybdenum (Mo) increases endogenous phenolics, proline and photosynthetic pigments and the phytoremediation potential of the industrially important plant Ricinus communis L. for removal of cadmium from contaminated soil.

Cadmium (Cd) in agricultural soil negatively affects crops yield and compromises food safety. Remediation of polluted soil is necessary for the re-establishment of sustainable agriculture and to prevent hazards to human health and environmental pollution. Phytoremediation is a promising technology for decontamination of polluted soil. The present study investigated the effect of molybdenum (Mo) (0.5, 1.0 and 2.0 ppm) on endogenous production of total phenolics and free proline, plant biomass and photosynthetic pigments in Ricinus communis plants grown in Cd (25, 50 and 100 ppm) contaminated soils and the potential for Cd phytoextraction. Mo was applied via seed soaking, soil addition and foliar spray. Foliar sprays significantly increased plant biomass, Cd accumulation and bioconcentration. Phenolic concentrations showed significantly positive correlations with Cd accumulation in roots (R 2 = 0.793, 0.807 and 0.739) and leaves (R 2 = 0.707, 721 and 0.866). Similarly, proline was significantly positively correlated with Cd accumulation in roots (R 2 = 0.668, 0.694 and 0.673) and leaves (R 2 = 0.831, 0.964 and 0.930). Foliar application was found to be the most effective way to deliver Mo in terms of increase in plant growth, Cd accumulation and production of phenolics and proline