Exploration and Practice of Building High-level Higher Vocational Colleges in Provincial Areas

In order to thoroughly implement the spirit of the National Vocational Education Conference and fully implement the "National Vocational Education Reform Implementation Plan" and "Opinions on Promoting the High-Quality Development of Modern Vocational Education", Guangdong Province has launched a provincial high-level vocational college construction plan. Our school closely adheres to the core goal of "creating characteristics, improving quality, and strengthening the brand", takes the fundamental task of cultivating people with moral integrity, takes accelerating the modernization of education as the main line, and firmly grasps the promotion of the "Belt and Road" international cooperation and the construction of Guangdong, Hong Kong and Macao University Bay Area and other major historical opportunities, in line with the reform and development trends of higher education, explore the development of party building, majors, teachers and management levels, comprehensively improve the quality and efficiency of education, and lay the foundation for striving to become a first-class higher vocational college in the province

Research on the Construction of Computer High Level Professional Groups in Higher Vocational Colleges under the Background of the Greater Bay Area

With the deepening of the construction of the Guangdong Hong Kong Macao Greater Bay Area, the goal of building a high-level professional group in vocational colleges is to optimize the professional structure to meet industrial demands, take industrial demands as the fundamental basis for forming professional groups, and cultivate high-quality technical and skilled talents. Our school closely focuses on the construction and development plan of the Greater Bay Area, builds a high-level computer professional group, and strives to promote the integration of industry and education. In order to improve the quality of teaching and promote the high-quality development of talent cultivation in vocational colleges, we have proposed construction ideas and measures

catena-Poly[[[aqua­pyridine­zinc(II)]-μ2-3,3′-(p-phenyl­ene)diacrylato] pyridine solvate]

The title compound, {[Zn(C12H8O4)(C5H5N)(H2O)]·C5H5N}n, has been prepared by hydro­thermal reaction. The ZnII atom is six-coordinated by four carboxyl­ate O atoms of two p-phenylenediacrylate (ppda2−) ligands, one N atom of a pyridine mol­ecule and one O atom of a water mol­ecule in a distorted octa­hedral environment. The carboxyl­ate groups of the ppda2− anions are in a bridging–chelating mode, in which two O atoms chelate one Zn2+ ion. These connections result in an extended chain structure. Parallel packing of the chains forms a two-dimensional network with inter­molecular edge-to-face inter­actions. Further linkages between the layers through O—H⋯O hydrogen-bonding inter­actions result in a three-dimensional supra­molecular architecture with one-dimensional recta­nglar channels

The Exploration and Practice of the Construction of Civic Politics in Computer Science Courses under the Perspective of “Three-Whole Education”

Taking the computer application technology professional group of Guangdong Innovation Technology College as an example, we study the problems of computer professional group in the construction of curriculum thinking politics, firstly, we explore the basic requirements of curriculum thinking politics from the perspective of “ Three-Whole Education “, then we explore the value of curriculum thinking politics, and then we study the top design and bottom implementation of talent training of professional group from many aspects. Then, we will explore the value of curriculum thinking and politics, and then carry out research from various aspects such as top-level design and bottom-level implementation of professional group talent training. We will build the construction pattern of “Three-Whole Education”, and combine with the construction of professional groups to build the construction pattern of the curriculum of professional groups in terms of talent training objectives, thinking and political objectives, thinking and political content, etc., so as to promote the construction of the curriculum of the provincial-level professional group of computer application technology in our university and realize the educational goal of cultivating people with moral character

The role of circadian clock in astrocytes: From cellular functions to ischemic stroke therapeutic targets

Accumulating evidence suggests that astrocytes, the abundant cell type in the central nervous system (CNS), play a critical role in maintaining the immune response after cerebral infarction, regulating the blood-brain barrier (BBB), providing nutrients to the neurons, and reuptake of glutamate. The circadian clock is an endogenous timing system that controls and optimizes biological processes. The central circadian clock and the peripheral clock are consistent, controlled by various circadian components, and participate in the pathophysiological process of astrocytes. Existing evidence shows that circadian rhythm controls the regulation of inflammatory responses by astrocytes in ischemic stroke (IS), regulates the repair of the BBB, and plays an essential role in a series of pathological processes such as neurotoxicity and neuroprotection. In this review, we highlight the importance of astrocytes in IS and discuss the potential role of the circadian clock in influencing astrocyte pathophysiology. A comprehensive understanding of the ability of the circadian clock to regulate astrocytes after stroke will improve our ability to predict the targets and biological functions of the circadian clock and gain insight into the basis of its intervention mechanism

Regulation of Wnt Singaling Pathway by Poly (ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Lung Cancer in Mice Induced by Benzo(a)pyrene Inhalation Exposure

Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon that specifically causes cancer and is widely distributed in the environment. Poly (ADP-ribosylation), as a key post-translational modification in BaP-induced carcinogenesis, is mainly catalyzed by poly (ADP-ribose) glycohydrolase (PARG) in eukaryotic organisms. Previously, it is found that PARG silencing can counteract BaP-induced carcinogenesis in vitro, but the mechanism remained unclear. In this study, we further examined this process in vivo by using heterozygous PARG knockout mice (PARG+/−). Wild-type and PARG+/− mice were individually treated with 0 or 10 μg/m3 BaP for 90 or 180 days by dynamic inhalation exposure. Pathological analysis of lung tissues showed that, with extended exposure time, carcinogenesis and injury in the lungs of WT mice was progressively worse; however, the injury was minimal and carcinogenesis was not detected in the lungs of PARG+/− mice. These results indicate that PARG gene silencing protects mice against lung cancer induced by BaP inhalation exposure. Furthermore, as the exposure time was extended, the protein phosphorylation level was down-regulated in WT mice, but up-regulated in PARG+/− mice. The relative expression of Wnt2b and Wnt5b mRNA in WT mice were significantly higher than those in the control group, but there was no significant difference in PARG+/− mice. Meanwhile, the relative expression of Wnt2b and Wnt5b proteins, as assessed by immunohistochemistry and Western blot analysis, was significantly up-regulated by BaP in WT mice; while in PARG+/− mice it was not statistically affected. Our work provides initial evidence that PARG silencing suppresses BaP induced lung cancer and stabilizes the expression of Wnt ligands, PARG gene and Wnt ligands may provide new options for the diagnosis and treatment of lung cancer

Research on the Collaborative Education Model between School and Enterprise for Computer Majors Based on Huawei Certification Standards

In recent years, With the rapid development of the computer industry, The requirements for computer talents are also increasing. At present, some universities’ talent cultivation models cannot meet the development requirements of the computer industry. In response to this situation, this article proposes a school enterprise collaborative education model based on Huawei standards, guided by market demand and starting from school enterprise collaborative education, aiming to improve the quality of talent cultivation from multiple aspects such as professional construction, school enterprise cooperation, and course assessment methods

Research on the Construction of Computer High Level Professional Groups in Higher Vocational Colleges under the Background of the Greater Bay Area

With the deepening of the construction of the Guangdong Hong Kong Macao Greater Bay Area, the goal of building a high-level professional group in vocational colleges is to optimize the professional structure to meet industrial demands, take industrial demands as the fundamental basis for forming professional groups, and cultivate high-quality technical and skilled talents. Our school closely focuses on the construction and development plan of the Greater Bay Area, builds a high-level computer professional group, and strives to promote the integration of industry and education. In order to improve the quality of teaching and promote the high-quality development of talent cultivation in vocational colleges, we have proposed construction ideas and measures