Cataloguing the World Wide Web: CORC at Edinburgh University

This article examines Edinburgh University Library’s experience of using OCLC’s Co-operative Online Resource Catalogue (CORC). It discusses the project phase of CORC, its functionality, including automatic metadata harvesting and its ability to map between MARC and Dublin Core metadata formats. It also looks at how CORC fits into Edinburgh University Library’s policies regarding web resources, highlighting benefits and concerns associated with the system.Postprin

SUNCAT: The serials union catalogue for the UK research community

SUNCAT is the national Serials Union CATalogue for the UK research community and is available at http://www.suncat.ac.uk SUNCAT is a freely available tool to help both researchers and librarians locate serials held in the UK. It contains serials bibliographic and holdings information from over 60 UK research libraries, including the British Library and the National Libraries of Scotland and Wales. The catalogue also contains high quality bibliographic records from CONSER and the ISSN Register. SUNCAT is provided by EDINA, a Joint Information Systems Council (JISC) funded national data centre based at the University of Edinburgh, with partners Ex Libris, who supply the Library Management System, Aleph 500, underpinning the service

Cataloguing the World Wide Web:CORC at Edinburgh University

This article examines Edinburgh University Library’s experience of using OCLC’s Cooperative Online Resource Catalogue (CORC). It discusses the project phase of CORC, its functionality, including automatic metadata harvesting and its ability to map between MARC and Dublin Core metadata formats. It also looks at how CORC fits into Edinburgh University Library’s policies regarding web resources, highlighting benefits and concerns associated with the system.</p

Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid

Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with an IgG autoimmune response to the hemidesmosomal protein BP180. Passive transfer of antibodies to the murine BP180 (mBP180) ectodomain triggers a blistering skin disease in mice that depends on complement activation and neutrophil infiltration and closely mimics human BP. In the present study, we show that mast cells (MCs) play a crucial role in experimental BP. Wild-type mice injected intradermally with pathogenic anti-mBP180 IgG exhibited extensive MC degranulation in skin, which preceded neutrophil infiltration and subsequent subepidermal blistering. In contrast, mice genetically deficient in MCs or MC-sufficient mice pretreated with an inhibitor of MC degranulation failed to develop BP. Further, MC-deficient mice reconstituted in skin with MCs became susceptible to experimental BP. Despite the activation of complement to yield C3a and C5a, in the absence of MCs, accumulation of neutrophils at the injection site was blunted. The lack of response due to MC deficiency was overcome by intradermal administration of a neutrophil chemoattractant, IL-8, or by reconstitution of the injection sites with neutrophils. These findings provide the first direct evidence to our knowledge that MCs play an essential role in neutrophil recruitment during subepidermal blister formation in experimental BP