2,443 research outputs found
European Demographic Datasheet 2016
The European Demographic Datasheet 2016 shows key demographic data, population trends and projections until 2050. It covers fertility, mortality, migration and population structure, including population ageing, and their changes. The datasheet combines data for all countries of Europe and for broader European regions, as well as maps, population pyramids, tables, graphs and featured thematic boxes. It pays special attention to the importance of migration for the current and future population changes across the continent and to the alternative indicators of population ageing. In comparison to the Data Sheet Poster, the online version provides expanded data coverage, additional maps and population pyramids, ranking charts and details about data sources and definitions. It also allows users to download all data and images
Microstructural enrichment functions based on stochastic Wang tilings
This paper presents an approach to constructing microstructural enrichment
functions to local fields in non-periodic heterogeneous materials with
applications in Partition of Unity and Hybrid Finite Element schemes. It is
based on a concept of aperiodic tilings by the Wang tiles, designed to produce
microstructures morphologically similar to original media and enrichment
functions that satisfy the underlying governing equations. An appealing feature
of this approach is that the enrichment functions are defined only on a small
set of square tiles and extended to larger domains by an inexpensive stochastic
tiling algorithm in a non-periodic manner. Feasibility of the proposed
methodology is demonstrated on constructions of stress enrichment functions for
two-dimensional mono-disperse particulate media.Comment: 27 pages, 12 figures; v2: completely re-written after the first
revie
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation
Objective Mitochondrial disturbances of energy-generating systems in childhood are a heterogeneous group of disorders. The aim of this multi-site survey was to characterise the natural course of a novel mitochondrial disease with ATP synthase deficiency and mutation in the TMEM70 gene.
Methods Retrospective clinical data and metabolic profiles were collected and evaluated in 25 patients (14 boys, 11 girls) from seven European countries with a c. 317-2A -> G mutation in the TMEM70 gene.
Results Severe muscular hypotonia (in 92% of newborns), apnoic spells (92%), hypertrophic cardiomyopathy (HCMP; 76%) and profound lactic acidosis (lactate 5-36 mmol/l; 92%) with hyperammonaemia (100-520 mu mol/l; 86%) were present from birth. Ten patients died within the first 6 weeks of life. Most patients surviving the neonatal period had persisting muscular hypotonia and developed psychomotor delay. HCMP was non-progressive and even disappeared in some children. Hypospadia was present in 54% of the boys and cryptorchidism in 67%. Increased excretion of lactate and 3-methylglutaconic acid (3-MGC) was observed in all patients. In four surviving patients, life-threatening hyperammonaemia occurred during childhood, triggered by acute gastroenteritis and prolonged fasting.
Conclusions ATP synthase deficiency with mutation in TMEM70 should be considered in the diagnosis and management of critically ill neonates with early neonatal onset of muscular hypotonia, HCMP and hypospadias in boys accompanied by lactic acidosis, hyperammonaemia and 3-MGC-uria. However, phenotype severity may vary significantly. The disease occurs frequently in the Roma population and molecular-genetic analysis of the TMEM70 gene is sufficient for diagnosis without need of muscle biopsy in affected children
Minimal Model for Sand Dunes
We propose a minimal model for aeolian sand dunes. It combines an analytical
description of the turbulent wind velocity field above the dune with a
continuum saltation model that allows for saturation transients in the sand
flux. The model provides a qualitative understanding of important features of
real dunes, such as their longitudinal shape and aspect ratio, the formation of
a slip face, the breaking of scale invariance, and the existence of a minimum
dune size.Comment: 4 pages, 4 figures, replaced with publishd versio
Entanglement and Timing-Based Mechanisms in the Coherent Control of Scattering Processes
The coherent control of scattering processes is considered, with electron
impact dissociation of H used as an example. The physical mechanism
underlying coherently controlled stationary state scattering is exposed by
analyzing a control scenario that relies on previously established entanglement
requirements between the scattering partners. Specifically, initial state
entanglement assures that all collisions in the scattering volume yield the
desirable scattering configuration. Scattering is controlled by preparing the
particular internal state wave function that leads to the favored collisional
configuration in the collision volume. This insight allows coherent control to
be extended to the case of time-dependent scattering. Specifically, we identify
reactive scattering scenarios using incident wave packets of translational
motion where coherent control is operational and initial state entanglement is
unnecessary. Both the stationary and time-dependent scenarios incorporate
extended coherence features, making them physically distinct. From a
theoretical point of view, this work represents a large step forward in the
qualitative understanding of coherently controlled reactive scattering. From an
experimental viewpoint, it offers an alternative to entanglement-based control
schemes. However, both methods present significant challenges to existing
experimental technologies
Magnetophonon resonance in photoluminescence excitation spectra of magnetoexcitons in GaAs/Al0.3Ga0.7As superlattice
Strong increase in the intensity of the peaks of excited magneto-exciton (ME)
states in the photoluminescence excitation (PLE) spectra recorded for the
ground heavy-hole magneto-excitons (of the 1sHH type) has been found in a
GaAs/AlGaAs superlattice in strong magnetic field B applied normal to the
sample layers. While varying B the intensities of the PLE peaks have been
measured as functions of energy separation between excited ME peaks
and the ground state of the system. The resonance profiles have been found to
have maxima at close to the energy of the GaAs LO-phonon.
However, the value of depends on quantum numbers of the
excited ME state. The revealed very low quantum efficiency of the investigated
sample allows us to ascribe the observed resonance to the enhancement of the
non-radiative magneto-exciton relaxation rate arising due to LO-phonon
emission. The presented theoretical model, being in a good agreement with
experimental observations, provides a method to extract 1sHH magneto-exciton
``in-plane" dispersion from the dependence of on the
excited ME state quantum numbers.Comment: 9 pages, 6 figure
Magneto infra-red absorption in high electronic density GaAs quantum wells
Magneto infra-red absorption measurements have been performed in a highly
doped GaAs quantum well which has been lifted off and bonded to a silicon
substrate, in order to study the resonant polaron interaction. It is found that
the pinning of the cyclotron energy occurs at an energy close to that of the
transverse optical phonon of GaAs. This unexpected result is explained by a
model taking into account the full dielectric constant of the quantum well.Comment: 4 pages, 4 figures, to be published in Phys. Rev. Let
Rapid and Precise Semi-Automatic Axon Quantification in Human Peripheral Nerves
We developed a time-efficient semi-automated axon quantification method using freeware in human cranial nerve sections stained with paraphenylenediamine (PPD). It was used to analyze a total of 1238 facial and masseteric nerve biopsies. The technique was validated by comparing manual and semi-automated quantification of 129 (10.4%) randomly selected biopsies. The software-based method demonstrated a sensitivity of 94% and a specificity of 87%. Semi-automatic axon counting was significantly faster (p<0.001) than manual counting. It took 1hour and 47minutes for all 129 biopsies (averaging 50sec per biopsy, 0.04seconds per axon). The counting process is automatic and does not need to be supervised. Manual counting took 21hours and 6minutes in total (average 9minutes and 49seconds per biopsy, 0.52seconds per axon). Our method showed a linear correlation to the manual counts (R=0.944 Spearman rho). Attempts have been made by several research groups to automate axonal load quantification. These methods often require specific hard- and software and are therefore only accessible to a few specialized laboratories. Our semi-automated axon quantification is precise, reliable and time-sparing using publicly available software and should be useful for an effective axon quantification in various human peripheral nerves
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