Modified biovectors for the tuneable activation of anti-platelet carbon monoxide release

This communication describes the anti-platelet effects of a new class of cis-rhenium(II)- dicarbonyl-vitamin B12 complexes (B12-ReCORMs) with tuneable CO releasing properties

Mineral Composite Plaster Containing Hollow Glass Microspheres and CSA Cement for Building Insulation

Renovation of old buildings plays a key role in the sustainable energy transition because they are often poorly insulated and, therefore, lose a lot of heat through walls and ceilings. An important measure of renovation is façade insulation. Established and widely used materials include rigid expanded polystyrene (EPS) and extruded polystyrene (XPS) insulation boards. However, these boards do not easily follow the form of non-planar surfaces such as individually formed, ornamented, or bent façades. Furthermore, fire protection of these boards requires the addition of, for example, hazardous brominated flame retardants that impede recycling. This paper investigates a novel alternative insulating composite plaster. It is purely inorganic and can be applied easily by casting or wet spraying to any wall or ceiling element. The composite material consists of only two components: micro hollow glass microspheres as the insulating light component and calcium sulfoaluminate cement as the binder. Various compositions containing these components were cast, hydraulically set, and characterized with respect to microstructure, phase development during hydration, and thermal conductivity. With an increasing amount of hollow glass spheres, the density decreased to less than 0.2 g·cm−1, and the thermal conductivity reached 0.04 to 0.05 W·m−1K−1, fulfilling the demands of building insulation

Studium - Erwerbstaetigkeit zur oekonomischen und sozialen Situation Oldenburger Absolventen der Studiengaenge Diplom-Sozialwissenschaften und Diplom-Wirtschaftswissenschaften. Eine empirische Verbleibsstudie

SIGLEIAB-94-158-31-NS AN 808 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Modified biovectors for the tuneable activation of anti-platelet carbon monoxide release

This communication describes the anti-platelet effects of a new class of cis-rhenium(II)-dicarbonyl-vitamin B12 complexes (B12-ReCORMs) with tuneable CO releasing properties

Bio-based succinate from sucrose: High-resolution 13 C metabolic flux analysis and metabolic engineering of the rumen bacterium Basfia succiniciproducens

Succinic acid is a platform chemical of recognized industrial value and accordingly faces a continuous challenge to enable manufacturing from most attractive raw materials. It is mainly produced from glucose, using microbial fermentation. Here, we explore and optimize succinate production from sucrose, a globally applied substrate in biotechnology, using the rumen bacterium Basfia succiniciproducens DD1. As basis of the strain optimization, the yet unknown sucrose metabolism of the microbe was studied, using C-13 metabolic flux analyses. When grown in batch culture on sucrose, the bacterium exhibited a high succinate yield of 1 mol mol(-1) and a by-product spectrum, which did not match the expected PTS-mediated sucrose catabolism. This led to the discovery of a fructokinase, involved in sucrose catabolism. The flux approach unraveled that the fructokinase and the fructose PTS both contribute to phosphorylation of the fructose part of sucrose. The contribution of the fructokinase reduces the undesired loss of the succinate precursor PEP into pyruvate and into pyruvate-derived by-products and enables increased succinate production, exclusively via the reductive TCA cycle branch. These findings were used to design superior producers. Mutants, which (i) overexpress the beneficial fructokinase, (II) lack the competing fructose PTS, and (iii) combine both traits, produce significantly more succinate. In a fed-batch process, B. succiniciproducens Delta fruA achieved a titer of 71 g L-1 succinate and a yield of 2.5 mol mol(-1) from sucrose

Improved riboflavin production with Ashbya gossypii from vegetable oil based on 13 C metabolic network analysis with combined labeling analysis by GC/MS, LC/MS, 1D, and 2D NMR

The fungus Ashbya gossypii is an important industrial producer of riboflavin, i.e. vitamin B-2. In order to meet the constantly increasing demands for improved production processes, it appears essential to better understand the underlying metabolic pathways of the vitamin. Here, we used a highly sophisticated set-up of parallel C-13 tracer studies with labeling analysis by GC/MS, LC/MS, 1D, and 2D NMR to resolve carbon fluxes in the overproducing strain A. gossypii B2 during growth and subsequent riboflavin production from vegetable oil as carbon source, yeast extract, and supplemented glycine. The studies provided a detailed picture of the underlying metabolism. Glycine was exclusively used as carbon-two donor of the vitamin's pyrimidine ring, which is part of its iso-alloxazine ring structure, but did not contribute to the carbon-one metabolism due to the proven absence of a functional glycine cleavage system. The pools of serine and glycine were closely connected due to a highly reversible serine hydroxymethyltransferase. Transmembrane formate flux simulations revealed that the one-carbon metabolism displayed a severe bottleneck during initial riboflavin production, which was overcome in later phases of the cultivation by intrinsic formate accumulation. The transiently limiting carbon-one pool was successfully replenished by time-resolved feeding of small amounts of formate and serine, respectively. This increased the intracellular availability of glycine, serine, and formate and resulted in a final riboflavin titer increase of 45%

Does Female Empowerment Promote Economic Development? IZA Discussion Paper No. 5637

Abstract Empirical evidence suggests that money in the hands of mothers (as opposed to their husbands) benefits children. Does this observation imply that targeting transfers to women is good economic policy? We develop a series of noncooperative family bargaining models to understand what kind of frictions can give rise to the observed empirical relationships. We then assess the policy implications of these models. We find that targeting transfers to women can have unintended consequences and may fail to make children better off. Moreover, different forms of empowering women may lead to opposite results. More research is needed to distinguish between alternative theoretical models. * We than