28 research outputs found
Wirtschaftlichkeit der Kraft-Waerme-Kopplung und Hindernisse fuer ihren Ausbau durch kommunale Versorgungsunternehmen
SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Avaliação da Acessibilidade de um Áudio Game por Inspeção de Conformidade
Audio games são jogos nos quais a interface do usuário e os eventos do jogo utilizam sons em vez de gráficos como o principal meio para transmitir informações ao jogador. Neste trabalho, a inspeção de conformidade é apresentada como um método para a avaliação da acessibilidade de audio games antes de realizar testes com usuários. O audio game avaliado consiste em um jogo estilo pista rolante, no qual o carro do jogador deve marcar pontos desviando de outros carros. A avaliação identificou dez problemas intermediários e menores, relacionados com ainstalação e acesso ao jogo, navegação em menu, entrada de interação, ambiente do jogo e representação de personagem. Os problemas identificados serão corrigidos para a realização de uma avaliação com usuários
CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease
Clinical signs of experimental autoimmune encephalomyelitis (EAE) are associated with the selective recruitment of CD4+ memory (CD45RBlow CD44high) T cells into the central nervous system (CNS). However, we have found that many of these recently recruited memory cells are CD44low, suggesting that the CD44 antigen may be involved in, and transiently lost during, the extravasation process. Indeed, administration of a CD44‐specific antibody (IM7.8.1) induced leucocyte CD44 shedding and both prevented the development and ameliorated the severity of established EAE by inhibiting mononuclear cell infiltration into the CNS. Trafficking of cells into lymph nodes, however, a property mainly of naïve cells, was essentially unaffected. In contrast, treatment with antibody to very late activation antigen‐4 (VLA‐4) prevented homing to both the CNS and to lymph nodes. This study contests previous reports that dismissed a role for CD44 in inflammation of the CNS and, coupled with observations in murine dermatitis and arthritis, suggests that CD44 is involved in the homing of primed lymphocytes to sites of inflammation. CD44 should therefore be considered a target for immunotherapy of T‐cell‐mediated inflammatory diseases, such as multiple sclerosis