Assessing the global and regional impact of primary cardiomyopathies: The Global Burden of Diseases, Injuries and Risk Factors (GBD 2010) Study

Primary cardiomyopathies affect individuals of all ages and ethnic groups in all regions of the world and are associated with significant morbidity and mortality. Though these conditions are globally prevalent, lack of rigorous epidemiological analysis on a worldwide scale has prevented accurate estimates of the burden of this subset of cardiac diseases on regional populations. The Global Burden of Diseases, Injuries and Risk Factors (GBD 2010) Study was designed to address such analytical shortfalls by delivering data-driven estimates of epidemiological parameters for nearly 200 diseases and injuries, including the primary cardiomyopathies. The methodology utilized to generate GBD 2010 disease burden estimates for the primary cardiomyopathies is described. Preliminary epidemiologic data for the study's 21 global regions is then presented and discussed, along with evaluation of challenges and future opportunities in addressing the burden of primary cardiomyopathies

Overview of the COMPASS results

COMPASS addressed several physical processes that may explain the behaviour of important phenomena. This paper presents results related to the main fields of COMPASS research obtained in the recent two years, including studies of turbulence, L–H transition, plasma material interaction, runaway electron, and disruption physics: • Tomographic reconstruction of the edge/SOL turbulence observed by a fast visible camera allowed to visualize turbulent structures without perturbing the plasma. • Dependence of the power threshold on the X-point height was studied and related role of radial electric field in the edge/SOL plasma was identified. • The effect of high-field-side error fields on the L–H transition was investigated in order to assess the influence of the central solenoid misalignment and the possibility to compensate these error fields by low-field-side coils. • Results of fast measurements of electron temperature during ELMs show the ELM peak values at the divertor are around 80% of the initial temperature at the pedestal. • Liquid metals were used for the first time as plasma facing material in ELMy H-mode in the tokamak divertor. Good power handling capability was observed for heat fluxes up to 12 MW m−2 and no direct droplet ejection was observed. • Partial detachment regime was achieved by impurity seeding in the divertor. The evolution of the heat flux footprint at the outer target was studied. • Runaway electrons were studied using new unique systems—impact calorimetry, carbon pellet injection technique, wide variety of magnetic perturbations. Radial feedback control was imposed on the beam. • Forces during plasma disruptions were monitored by a number of new diagnostics for vacuum vessel (VV) motion in order to contribute to the scaling laws of sideways disruption forces for ITER. • Current flows towards the divertor tiles, incl. possible short-circuiting through PFCs, were investigated during the VDE experiments. The results support ATEC model and improve understanding of disruption loads