ORGANIZATIONAL AND LEGAL REGULATION PROCEDURE FOR CIRCULATION OF EXTEMPORAL MEDICINES BASED ON PHARMACEUTICAL LAW

Introduction. The paper studied the situation regarding the production of medicines in pharmacies. Established that the presence of the pharmacy manufacture of medicines, patients entitled to receive medicines made to the needs of individuals. Goal – to study the organizational and legal procedure of regulation of extemporal medicines by developing of the algorithm for determining the legal act used in the event of conflict based on the law pharmaceutical law. Materials and methods. The materials of the study were legal acts of Ukraine: Laws of Ukraine, Decrees of the Cabinet of Ministers of Ukraine, Orders of the Ministry of Healthcare of Ukraine. The research methods were legal, documentary and comparative analyzes. Results and discussion. However, production of extemporaneous preparations in the pharmacy requires a production base and the appropriate staff. Therefore, the authors based on pharmaceutical law proposed organizational and legal procedure regarding the regulation of extemporaneous preparations by developing the algorithm for determining the legal act which should follow in the event of conflicts concerning the law. Conclusions. Based on pharmaceutical law held organizational and legal procedure for the regulation of circulation of extemporal medicines. Proposed the algorithm for determining of the legal act used in the practice of pharmacy professionals. Considered the professional status of an authorized person on the stage of quality control of extemporal medicines in their treatment in healthcare institutions of private property

Response of a cold-electron bolometer on thz radiation from a long yba2cu3o7−δ bicrystal josephson junction

The response of the Cold-Electron Bolometers (CEBs), integrated into a 2-D array of dipole antennas, has been measured by irradiation from YBa2Cu3O7−δ (YBCO) 50 \ub5m long Josephson junction into the THz region at frequencies from 0.1 to 0.8 THz. The possibility of controlling the amplitude-frequency characteristic is demonstrated by the external magnetic field in the traveling wave regime of a long Josephson junction. The YBCO junction has been formed on the bicrystal Zr1−xYxO2 (YSZ) substrate by magnetron sputtering and etching of the film. CEBs have been fabricated using an Al multilayer structure by a self-aligned shadow evaporation technique on Si substrate. Both receiver and oscillator have been located inside the same cryostat at 0.3 K and 2.7 K plates, respectively

Microwave photon detection by an Al Josephson junction

An aluminium Josephson junction (JJ), with a critical current suppressed by a factor of three compared with the maximal value calculated from the gap, is experimentally investigated for application as a threshold detector for microwave photons. We present the preliminary results of measurements of the lifetime of the superconducting state and the probability of switching by a 9 GHz external signal. We found an anomalously large lifetime, not described by the Kramers\u27 theory for the escape time over a barrier under the influence of fluctuations. We explain it by the phase diffusion regime, which is evident from the temperature dependence of the switching current histograms. Therefore, phase diffusion allows for a significant improvement of the noise immunity of a device, radically decreasing the dark count rate, but it will also decrease the single-photon sensitivity of the considered threshold detector. Quantization of the switching probability tilt as a function of the signal attenuation for various bias currents through the JJ is observed, which resembles the differentiation between N and N + 1 photon absorption

Record electron self-cooling in cold-electron bolometers with a hybrid superconductor-ferromagnetic nanoabsorber and traps

The Cosmic Microwave Background (CMB) radiation is the only observable that allows studying the earliest stage of the Universe. Radioastronomy instruments for CMB investigation require low working temperatures around 100 mK to get the necessary sensitivity. On-chip electron cooling of receivers is a pathway for future space missions due to problems of dilution fridges at low gravity. Here, we demonstrate experimentally that in a Cold-Electron Bolometer (CEB) a theoretical limit of electron cooling down to 65 mK from phonon temperature of 300 mK can be reached. It is possible due to effective withdrawing of hot electrons from the tunnel barrier by double stock, special traps and suppression of Andreev Joule heating in hybrid Al/Fe normal nanoabsorber

Spectral characteristics of the double-folded slot antennas with cold-electron bolometers for the 220/240 GHz channels of the LSPE instrument

We present the results of the experimental and theoretical study of the resonant properties and noise of a single cell of a receiving system based on cold-electron bolometers (CEB) with a double-folded slot antenna and coplanar lines. The system was designed to receive signals at 220/240 GHz frequencies with a 5% bandwidth. In measurements, we used the samples of the double-folded slot antennas with slot lengths of 162 um and coplanar line lengths from 185 to 360 um. Measurements of the resonance properties of CEB located at 0.3 K cryostat plate were carried out using a generator based on a high-temperature YBCO Josephson junction located inside the same cryostat at 4 K plate. This arrangement made it possible to obtain smooth amplitude-frequency characteristics with a clearly defined peak of a 15–21 GHz bandwidth at different frequencies. Based on these results, 2-D array of double-folded slot antennas with CEBs as 220/240 GHz LSPE channel prototype was calculated.The absorption efficiency of the array has reached 81% and 77% for 220 and 240 GHz channels, respectively

Observation of photon noise by cold-electron bolometers

We have observed the photon noise by measuring a response to the black body 350 GHz radiation and noise of the cold-electron bolometers (CEBs). The experimental results have been fit to the theoretical model of CEBs with two heat-balance equations. The measured noise has been decomposed into several terms with the help of theory. It is demonstrated that the photon noise exceeds any other noise components, which allows us to conclude that the bolometers measure the photon noise. Moreover, a peculiar shape of the noise dependence on the absorbed power originates completely from the photonic component according to the theory. In the additional experiment on heating of the cryostat plate together with the sample holder, we have observed the near independence of the noise on the electron temperature of the absorber, which has provided another proof of the presence of the photon noise in the first experiment. The least ratio between internal and photon noise equivalent powers, observed in our experiments, is 1.1 for the absorbed power of 1-2 pW

Observation of Photon Noise by a Parallel-Series Array of Cold-Electron Bolometers

The quasioptical qualification of cold-electron bolometers (CEB) operated in the cross-slot antenna at 350GHz, are presented. The photon noise observation by a parallel/series array of CEBs is demonstrated for power loads of the order of 1 pW. The experimental results have been fitted to theoretical model with two heat-balance equations for the absorber and for superconducting electrodes. The measured noise has been decomposed into several terms with the help of theory. It is demonstrated that the photon noise exceeds any other noise components at some voltage range, that allows us to conclude that the bolometers see the photon noise. A shape of the noise dependence on the bolometer voltage originates from the photonic component according to the theory. In the additional experiment on heating of the sample holder the photonic component is almost absent and the total noise is lower, proving the presence of the photon noise in the first experiment

Multifrequency seashell antenna based on resonant cold-electron bolometers with kinetic Inductance Nanofilters for CMB measurements

A novel type of the seashell slot antenna with internal filters by the capacitance of resonant cold-electron bolometers (RCEB) and kinetic inductance of the NbN superconducting nanostrip has been realized for multifrequency pixels. Seashell antenna gives the opportunity to connect opposite slots by coplanar waveguides (CPW) instead of microstrip lines (MSL). A conventional multifrequency pixel combines a wideband antenna and narrowband filters with long microstrip lines with unavoidable losses and overlaps. Another problem is the frequency dependent beam width due to a fixed pixel diameter for multiple frequencies. The main advantage of the seashell antenna with nano-filters is independent tuning of the separate pairs of slots for each frequency avoiding frequency dependence of the beam width. We used λ/2 slots for 75 and 105 GHz, feeding by CPW near the end of slots for RF matching. Each RCEB includes two SIN (Superconductor-Insulator-Normal) tunnel junctions with a nano-absorber and NbN kinetic inductance of 450 or 310 pH. SIN junctions had capacitances of 9.3 and 7.2 fF and absorber matched to a wave impedance of the antenna near 50 Ohm. Kinetic inductance value was estimated at the level of 35 pH/sq. RF testing was done at 300 mK irradiating this chip by sweep generator from 60 to 120 GHz. The response curves showed clear resonances at 75 and 105 GHz with a quality factor of 10 and 7. These experiments confirm that the seashell antenna with the internal RCEB filters can be used for frequency selection in compact multiband pixels