Measuring territorial cohesion trends in Europe: A correlation with EU Cohesion Policy

Territorial cohesion is a formal EU policy goal since 2010, when it was placed in the Lisbon Treaty, alongside the long-term EU goals of economic and social cohesion. Understandably, by itself, a policy goal is irrelevant if it cannot be assessed. In this light, this article discusses potential methodological approaches to measure territorial cohesion trends in a given territory, their advantages and limitations, based on existing literature. It uses European NUTS 2 and the Portuguese and Polish NUTS 3 as concrete case studies to assess territorial cohesion trends from 2005 to 2020 via a Territorial Cohesion Index. As such, it presents an updated and unique picture on the territorial cohesion trends in Europe and in two specific EU member states, based on available data. It concludes that measuring territorial cohesion trends is challenging mainly due to lack of available data in certain key dimensions of territorial cohesion, but it is possible and needed.info:eu-repo/semantics/publishedVersio

METRO - The role and future perspectives of Cohesion Policy in the planning of Metropolitan Areas and Cities. Policy brief: The role of metropolitan areas in the EU cohesion policy

This policy brief focuses on the role that metropolitan area plays, and may play, in the development, management and implementation of the EU cohesion policy. The information it includes is drawn from the ESPON METRO project, and in particular from the 9 in-depth case studies that have been analysed through the project: Barcelona Metropolitan Area, Brno Metropolitan Area, Brussels-Capital Region, Metropolitan City of Florence, Metropolitan Area of Gdańsk-Gdynia-Sopot, Lisbon Metropolitan Area, Métropole de Lyon, Riga Metropolitan Area, Metropolitan City of Turin. More in detail, the provided information discusses the different levels of engagement of metropolitan areas around Europe with the different stages of the EU cohesion policy development, the various programmes and instruments that have been put in place in different contexts as well as the coordination mechanisms that, in different metropolitan areas, have been put in place to ensure a stronger coherence between metropolitan governance and policy and the EU cohesion policy. The document also reflects on the engagement of the business actors and the civil society, as well as on the role that metropolitan areas are playing in the framework of the Recovery and Resilience Facility

METRO - The role and future perspectives of Cohesion Policy in the planning of Metropolitan Areas and Cities. Annex I: Conceptual framework and methodology

The scope of the ESPON METRO project is rather broad, as its research positions at the intersection of a number of fields, ranging from territorial governance and spatial planning, to public administration and policy analysis and European integration studies, up to regional development studies. In order to explore the role that metropolitan areas play as catalysts and drivers of global development, as a consequence of complex processes of socioeconomic reorganisation and rescaling that have evolved through time, and with particular reference to the European Union (EU) cohesion policy, the METRO research team has framed its action and analysis within a composite and articulated conceptual and methodological framework. In particular, the latter has been shaped in order to allow the researchers engaged in the project to answer the three main policy questions animating the study: PQ1 | What role do metropolitan areas play in the development, management and implementation of the cohesion policy? PQ2 | What is the added value of the cohesion policy in the planning and implementation of metropolitan policies? PQ3 | What role does the cohesion policy play in consolidating metropolitan governance and cooperation? The conceptual and methodological framework for the project has been developed during the first months of the research, building on the materials already included in the project proposal, that were further detailed and consolidated through: A thorough consideration of previous research works on similar matters as well as of the existing scientific literature in the field of metropolitan governance and European integration and Europeanisation. The interaction with the project’s Steering Committee Members during the METRO kick-off meeting (October the 9th, 2020), the comments received in response to the Delivery n.1 and the outcomes of the Steering Committee Meeting n. 2 (November the 16th, 2020) and 3 (February the 23rd, 2021). This Annex to the Final Report presents said conceptual framework and methodology more in detail

67. Radical radiotherapy of muscle-invading bladder cancer (BC): a retrospective analysis of 49 patients

Growing interest in the use of combined modality approaches for bladder-sparing procedures force radiation oncologists to optimise methods of radical radiotherapy. Since treatment policies have changed considerably over the last years, in this retrospective study we analysed feasibility of radical radiotherapy and outcomes of patients treated in our institution between 1992 and 2000. Study group comprised 49 consecutive BC patients aged 43 to 80 years (median 71), including three cases with clinically involved pelvic lymph nodes. There were 45 urothelial, and four other types of cancer (grade 1- four, 2 – 21, 3-nine, and unknown -14 cases). Six patients were referred for radiotherapy after nonradical operation. Treatment was delivered with the use of 60Co or LA five days a week, without planned interruptions. Thirty-two patients received elective irradiation of the pelvic lymph nodes to the dose 40 to 48 Gy, followed by the boost to the bladder to the total dose 60 to 66 Gy. Seventeen patients received total dose of 58 to 62 Gy to the bladder and perivesical tissue. Fraction doses ranged from 1.8 to 2.0 Gy. Treatment was prematurely stopped due to disease progression (PD), patient refusal, uraemia, in one case each, and intractable diarrhoea in six cases. After a median follow-up of 14 months (range 1 – 102) 23 patients died of PD. Median survival in the entire group is 159 months. Results of this study confirm relative efficacy of radiotherapy in BC. Further refinement of radiotherapy techniques is warranted to improve the outcome

METRO - The role and future perspectives of Cohesion Policy in the planning of Metropolitan Areas and Cities. Annex II: The role of Metropolitan areas within the EU cohesion policy

This Annex to the final Report presents and discusses in a comparative manner the evidence collected in the nine case studies that have been explored in the framework of the ESPON Targeted Analysis METRO – The role and future perspectives of cohesion policy in the planning of Metropolitan Areas and Cities (Annexes III to XI). More in detail, the document synthesizes and compares the information collected by the various research teams through the application of the project’s analytical protocol and as a consequence of their continuous interaction with the respective stakeholders. The report is organised following the three main policy questions that have been driving the analysis: PQ1 | What role do metropolitan areas and cities play in the development, management and implementation of the European Union (EU) cohesion policy? PQ2 | What is the added value of the EU cohesion policy in the planning and implementation of metropolitan policies? PQ3 | What role does the EU cohesion policy play in consolidating metropolitan governance and cooperation? These questions are answered through the comparative analysis and assessment of the territorial and institutional contexts in which the nine stakeholders involved in the projects are active: Metropolitan City of Turin (CMTo), Barcelona Metropolitan Area (AMB), Lisbon Metropolitan Area (LMA), Brno Metropolitan Area (BMA), Metropolitan Area of Gdańsk-Gdynia-Sopot (MAG), Metropolitan City of Florence (CMFi), Métropole de Lyon (MdL), Brussels-Capital Region (BCR), Riga Metropolitan Area (RMA)

A polygenic risk score for multiple myeloma risk prediction

There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach to improve their usefulness. Using 2361 MM cases and 1415 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, we computed a weighted and an unweighted PRS. We observed associations with MM risk with OR = 3.44, 95% CI 2.53–4.69, p = 3.55 × 10−15 for the highest vs. lowest quintile of the weighted score, and OR = 3.18, 95% CI 2.1 = 34–4.33, p = 1.62 × 10−13 for the highest vs. lowest quintile of the unweighted score. We found a convincing association of a PRS generated with 23 SNPs and risk of MM. Our work provides additional validation of previously discovered MM risk variants and of their combination into a PRS, which is a first step towards the use of genetics for risk stratification in the general population

Monkeypox Transmission and Pathogenesis in Prairie Dogs

During May and June 2003, the first cluster of human monkeypox cases in the United States was reported. Most patients with this febrile vesicular rash illness presumably acquired the infection from prairie dogs. Monkeypox virus was demonstrated by using polymerase chain reaction in two prairie dogs in which pathologic studies showed necrotizing bronchopneumonia, conjunctivitis, and tongue ulceration. Immunohistochemical assays for orthopoxviruses demonstrated abundant viral antigens in surface epithelial cells of lesions in conjunctiva and tongue, with less amounts in adjacent macrophages, fibroblasts, and connective tissues. Viral antigens in the lung were abundant in bronchial epithelial cells, macrophages, and fibroblasts. Virus isolation and electron microscopy demonstrated active viral replication in lungs and tongue. These findings indicate that both respiratory and direct mucocutaneous exposures are potentially important routes of transmission of monkeypox virus between rodents and to humans. Prairie dogs offer insights into transmission, pathogenesis, and new vaccine and treatment trials because they are susceptible to severe monkeypox infection