Data Censoring with Set-Membership Affine Projection Algorithm

In this paper, the set-membership affine projection (SM-AP) algorithm is utilized to censor non-informative data in big data applications. To this end, the probability distribution of the additive noise signal and the excess of the mean-squared error (EMSE) in steady-state are employed in order to estimate the threshold parameter of the single threshold SM-AP (ST-SM-AP) algorithm aiming at attaining the desired update rate. Furthermore, by defining an acceptable range for the error signal, the double threshold SM-AP (DT-SM-AP) algorithm is proposed to detect very large errors due to the irrelevant data such as outliers. The DT-SM-AP algorithm can censor non-informative and irrelevant data in big data applications, and it can improve the misalignment and convergence rate of the learning process with high computational efficiency. The simulation and numerical results corroborate the superiority of the proposed algorithms over traditional algorithms

Estimation of Average Annual Daily Bicycle Count Using Bike-Share GPS Data and Bike Counter Data for an Urban Active Transportation Network

In 2018, the City of Kelowna entered into a license agreement with Dropbike to operate a dockless bike-share pilot in and around the downtown core. The bikes were tracked by the user's cell phone GPS through the Dropbike app. The City's Active Transportation team recognized that this GPS data could help understand the routes used by cyclists which would then inform decision-making for infrastructure improvements. Using OSMnx and NetworkX, the map of Kelowna was converted into a graph network to map inaccurate, infrequent GPS points to the nearest street intersection, calculate the potential paths taken by cyclists and count the number of trips by street segment though the comparison of different path-finding models. Combined with the data from four counters around downtown, a mixed effects statistical model and a least squares optimization were used to estimate a relationship between the different traffic patterns of the bike-share and counter data. Using this relationship based on sparse data input from physical counting stations and bike share data, estimations and visualizations of the annual daily bicycle volume in downtown Kelowna were produced. The analysis, modelling and visualization helped to better understand how the bike network was being used in the urban center, including non-traditional routes such as laneways and highway crossings.Comment: Published in 17th International Conference on Data Science (ICDATA'21

A randomized clinical trial on the anti-tumoral effects of low molecular weight heparin in the treatment of esophageal cancer

The current treatment approaches for esophageal cancer are associated with poor survival, and there are ongoing efforts to find new and more effective therapeutic strategies. There are several reports on the antitumoral effects of low‐molecular‐weight heparins (LMWHs). We have assessed the possible survival benefit of LMWHs in esophageal malignancies. This was a randomized, single‐blind, multicenter, Phase II clinical trial on nonmetastatic esophageal cancer candidate for neoadjuvant chemoradiotherapy. Patients were randomly assigned to the chemoradiotherapy‐only arm or chemoradiotherapy plus enoxaparin arm using 1:1 allocation. Radiotherapy was delivered in 1.8‐Gy daily fractions to a dose of 50.4 Gy in both groups. Paclitaxel 50 mg/m2 and carboplatin (AUC 2) were administered weekly, concurrent with radiotherapy. In the intervention group, patients received enoxaparin (40 mg) and chemoradiation daily. 4–6 weeks after treatment, all patients underwent esophagectomy. After a median follow up of 7 months, estimated 1 year disease‐free survival (DFS) in the intervention group was 78.9% and was 70% in the control groups ( p = 0.5). Toxicity from the experimental treatment was minimal, and there were no treatment‐related deaths. A pathologically complete response in intervention and control group was 64.8% and 62.5%, respectively ( p = 0.9). There was a nonsignificant trend toward improved survival by the addition of enoxaparin to the concurrent chemoradiotherapy regimen. However, 1 y DFS of both groups were high as expected. A longer follow‐up and a larger sample size are required.delivered in 1.8-Gy daily fractions to a dose of 50.4 Gy in both groups. Paclitaxel 50 mg/m2 and carboplatin (AUC 2) were administered weekly concurrent with radiotherapy. In the intervention group, patients received enoxaparin (40 mg) daily as well as chemoradiation. Four to six weeks after treatment, all patients underwent esophagectomy. After a median follow up of 7 months,estimated one year disease free survival (1y DFS) in the intervention group was 78.9% and in the control groups was 70% (p=0.5). Toxicity from the experimental treatment was minimal and there were no treatment-related deaths. A Pathologically complete response in intervention and control group was 64.8% and 62.5%, respectively (p=0.9). There was a non-significant trend toward improved survival by the addition of enoxaparin to the concurrent chemoradiotherapy regimen. However, 1y DFS of both groups were high as expected. A longer follow-up and larger sample size is required

Isolation and molecular identification of Mycoplasma pulmonis from the respiratory tract of Rattus rattus

Background and Aim: Mycoplasma is the smallest self-replicating bacteria polymorphic are having a diameter of about 200-500 nm, and lees cell wall. Because of their small size and flexibility to easily pass through the filter membrane and contaminate represented. These organisms are unique in nature, the wide range of diseases among animals, especially respiratory & genitalia diseases were among the rodents.The aim this study was to isolate and identify the molecule Mycoplasma of Rats. Methods: With aim to isolation of mycoplasmas pulmonis, the tracheal samples were collected and cultured on the medium 243 and Microaerophilic was placed. Genomic DNA was isolated from bacteria grown. 16srRNA gene amplified with PCR. The PCR products, finally to identify the bacteria was purified, sequenced were a BLAST. Results: Macroscopic studies on the isolated colonies showed fried egg colonies were established. Based on the 16SrRNA sequencing studies, this bacterium belonging Mycoplasma genus & had 99% similarity to Mycoplasma pulmonis. Conclusions: Due to the lack of similarity of 100%, a new strain of bacterium, Mycoplasma pulmonis strain IRMT179 name were called. Finally, the gene bank was recorded with acceptation number KP836312. This study is the first time in Iran; Mycoplasma pulmonis was isolated from the respiratory tract an urban rat

Novel homozygous variants in the TMC1 and CDH23 genes cause autosomal recessive nonsyndromic hearing loss

Abstract Background Hereditary hearing loss (HL) is a heterogeneous and most common sensory neural disorder. At least, 76 genes have been reported in association with autosomal recessive nonsyndromic HL (ARNSHL). Herein, we subjected two patients with bilateral sensorineural HL in two distinct consanguineous Iranian families to figure out the underlying genetic factors. Methods Physical and sensorineural examinations were performed on the patients. Imaging also was applied to unveil any abnormalities in anatomical structures of the middle and inner ear. In order to decipher the possible genetic causes of the verified GJB2‐negative samples, the probands were subjected to whole‐exome sequencing and, subsequently, Sanger sequencing was applied for variant confirmation. Results Clinical examinations showed ARNSHL in the patients. After doing whole exome sequencing, two novel variants were identified that were co‐segregating with HL that were absent in 100 ethnically matched controls. In the first family, a novel homozygous variant, NM_138691.2: c.530T>C; p.(lle177Thr), in TMC1 gene co‐segregated with prelingual ARNSHL. In the second family, NM_022124.6: c.2334G>A; p.(Trp778*) was reported as a nonsense variant causing prelingual ARNSHL. Conclusion These findings can, in turn, endorse how TMC1 and CDH23 screening is critical to detecting HL in Iranian patients. Identifying TMC1 and CDH23 pathogenic variants doubtlessly help in the detailed genotypic characterization of HL

ANXA1 with Anti-Inflammatory Properties Might Contribute to Parkinsonism

We here describe the identification of a novel variant in the anti-inflammatory Annexin A1 protein likely to be the cause of disease in two siblings with autosomal recessive parkinsonism. The disease-segregating variant was ascertained through a combination of homozygosity mapping and whole genome sequencing and was shown to impair phagocytosis in zebrafish mutant embryos. The highly conserved variant, absent in healthy individuals and public SNP databases, affected a functional domain of the protein with neuroprotective properties. This study supports the hypothesis that damaged microglia might lead to impairments in the clearance of accumulated and aggregated proteins resulting in parkinsonism. ANN NEUROL 2021;90:319�323. © 2021 American Neurological Association