1,196 research outputs found
Assessment of risk for juvenile compared with adult criminal onset: Implications for policy, prevention and intervention
The dark triad of personality and hero/villain status as predictors of parasocial relationships with comic book characters
A longitudinal analysis of early risk factors for adult onset offending: What predicts a delayed criminal career?
SLC26A9 as a Potential Modifier and Therapeutic Target in Cystic Fibrosis Lung Disease
SLC26A9 belongs to the solute carrier family 26 (SLC26), which comprises membrane proteins involved in ion transport mechanisms. On the basis of different preliminary findings, including the phenotype of SlC26A9-deficient mice and its possible role as a gene modifier of the human phenotype and treatment response, SLC26A9 has emerged as one of the most interesting alternative targets for the treatment of cystic fibrosis (CF). However, despite relevant clues, some open issues and controversies remain. The lack of specific pharmacological modulators, the elusive expression reported in the airways, and its complex relationships with CFTR and the CF phenotype prevent us from conclusively understanding the contribution of SLC26A9 in human lung physiology and its real potential as a therapeutic target in CF. In this review, we summarized the various studies dealing with SLC26A9 expression, molecular structure, and function as an anion channel or transporter; its interaction and functional relationships with CFTR; and its role as a gene modifier and tried to reconcile them in order to highlight the current understanding and the gap in knowledge regarding the contribution of SLC26A9 to human lung physiology and CF disease and treatment
Treatment Outcomes of Treatment-NaĂŻve Hepatitis C Patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts
Co-infection with Hepatitis C (HCV) and HIV is common and HIV accelerates hepatic disease progression due to HCV. However, access to HCV treatment is limited and success rates are generally poor
Reflecting on studentsâ perspectives of a pre-entry psychology course in academic skills (2017-2021)
âAbusers are using COVID to enhance abuseâ:domestic abuse helpline workersâ perspectives on the impact of COVID-19 restrictions on those living with domestic abuse
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