4,253 research outputs found

    Guest Editorial

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    Acute viral bronchiolitis in South Africa: Diagnosis and current managemen

    Decision making in management of proximal fifth metatarsal fracture: a short review

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    Fifth metatarsal bone fracture is one of the most commonest fractures of the foot. The decision for surgical or conservative approach is still inconclusive. Scoring system, decision analysis model and classification system are established to weigh between surgical and conservation approaches. Its unique anatomy and surgical complication influence decision on optimal surgical approach. Therefore, the present review attempts to look at factors that might influence decision making in management of fifth metatarsal fracture

    Chronic effects of hydro-alcoholic artemisia absinthium extract on the liver enzymes and tissue changes of adult mal rat

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    Artemisia absinthium has many pharmacological effects, but toxic effects of it, were seen on nervous system and liver. Therefore, the aim of this study was to evaluate the chronic effects of different doses of Artemisia absinthium extract on the enzymes and histopathological changes of the liver tissue of adult normal male rat. Method and materials: In this experimental study, forty eight male Wistar rats were randomly divided into 6 groups of 8 as follows: Control, sham (recipient of distilled water) and 4 experimental groups that received Artemisia absinthium hydro- alcoholic extract at doses of 125, 250, 500 and 1000 mg/kg intraperitoneally.The data were analyzed using one-way ANOVA and Duncan post hoc tests. P≤0.05 was considered statistically significant. Results: After 8 weeks, doses of 125, 250 and 500 mg/kg could significantly reduce amount of ALT, AST and ALP. Dose of 1000 mg/kg increased ALT, AST and ALP. From the standpoint of histopathological study, doses of 125, 250 and 500 Artemisia absinthium had no significant side effect on liver tissue, but 1000 mg/kg caused destruction of liver cell membranes, enlargement of sinusoidal space, sporadic leukocyte infiltration, Kupffer cells hypertrophy, and vascular congestion.Conclusion: Maximum dose of Artemisia absinthium extract (1000 mg/kg) increased liver enzymes and destroy liver tissues of normal male rats.Keywords: Artemisia Absinthium, Enzymes, Histopathology, Liver, Ra

    Asthma - is survival good enough?

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    Advances in asthma management, particularly the introduction of controller medication of which inhaled corticosteroids are the most important, has resulted in a steady decline in asthma mortality in most countries. This is usually accompanied by a decline in episodes of near-fatal asthma attacks and hospitalisations, and a reduction in other indicators of asthma morbidity. These gains have led to a shift in thinking on the management of asthma, away from simply preventing death and hospitalisations, toward achieving and maintaining sustained control of all clinical features

    Gelam Honey: a review of its antioxidant, anti-inflammatory, anticancer and wound healing aspects

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    In recent years, there is a growing enthusiasm in honey which has potential health benefits, disease prevention and serves as substitution of modern medicine. Honey is a natural sweet product which is produced by honey bees from floral nectar and has been traditionally used to treat several diseases such as cardiovascular disease, diabetes mellitus, cancer and Alzheimer’s disease since ancient times. Gelam honey (GH) is one of the Malaysian wild monofloral honey which is widely used as traditional medicine by the local population. GH is enriched with several therapeutic properties namely, antioxidative, antiinflammatory, anticancer and accelerated wound healing activities. However, there is lack of literature focusing on the overall effects of GH and its medicinal value. This review paper summarises the phytochemistry characteristics of GH along with its therapeutic values which lead to a broad spectrum idea on several diseases. A concise clarification on the therapeutic properties of GH is expected to provide new knowledge to the scientific society in the era of modern globalization
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