China's Cultural Diplomacy in a New Era of Multilateralism: The Case of the China-Community of Latin American & Caribbean States (CELAC) Forum (CCF)

Cultural diplomacy has been one component of China's foreign policy since its very foundation. However, it is only in recent decades that culture has been wielded as a tool to serve high-reaching goals commensurate with China's rising superpower status and its capacity to contend for global hegemony. This study examines China's recent efforts to enhance cultural exchanges in multilateral and regional platforms. The primary aim is to analyse the rationale, motivations, main initiatives and strategies underpinning China's cultural diplomacy based on a conceptual framework centred on the notions of cultural diplomacy and hegemonic transition. The author begins by presenting the guiding conceptual framework and providing an overview of China's overall cultural diplomacy approach over the last two decades. The analysis then delves into China’s engagement in well-established and new multilateral platforms such as UNESCO, the Belt and Road Initiative (BRI), the BRICS group, and regional forums established between China and developing regions. Shifting the focus to Latin America, the research investigates the China-Community of Latin American and Caribbean States (CELAC) Forum (CCF) as a platform for cultural exchanges and an instrument of China’s cultural diplomacy, and systematizes its cultural initiatives, prioritized areas, key actors involved, and strategies. By way of conclusion, the study summarizes the main findings, assesses the trajectory of the CCF in the cultural dimension and proposes recommendations

Elections in Ecuador: An Emerging Alternative beyond the Left-Right Antagonism

On 11 April 2021 Ecuador's presidential run-off election will take place between leftist candidate Andrés Arauz from the UNES coalition and right-wing conservative Guillermo Lasso from the PSC-CREO alliance. Though this appears to be a conventional left-right battle, the successful first-round performance of Yaku Pérez from Pachakutik and Xavier Hervas from the ID surprised many observers. Ecuador's run-off represents the choice between two opposing models of development. Arauz seeks to advance ex-president Rafael Correa's anti-neoliberal "Citizen Revolution," while Lasso promotes the old neoliberal agenda. Both contenders are betting on revenues from extractivism to fund their development plans. In the first round, Arauz and Lasso avoided taking firm stances on issues related to the environment, gender, and sexual minorities. For the run-off, they have both "greened" their agendas and spun their positions as "women- and LGBT-friendly," recognizing the success of alternative third forces led by Pachakutik and the Izquierda Democrática (ID). Despite a left majority in the legislature, creating a unified leftist front is wishful thinking. The differences between Unión por la Esperanza (UNES) and Pachakutik are irreconcilable: the former seems incapable of turning away from its founding figure, Correa, and the indigenous movement continues to be internally fragmented. As both run-off candidates combined received only a little over half of the first-round vote, endorsements are currently a crucial battleground for the finalists. Pachakutik and the ID have announced they will support neither Arauz nor Lasso. The political tradition in Ecuador indicates that votes are not easily transferred, due to voters' weak identification with programmatic militancy and ideology. Whoever wins the presidential run-off will have to deal with an urgent and profound socio-economic crisis reinforced by the COVID-19 pandemic

Production of HIV Particles Is Regulated by Altering Sub-Cellular Localization and Dynamics of Rev Induced by Double-Strand RNA Binding Protein

Human immunodeficiency virus (HIV)-1 encoded Rev is essential for export from the nucleus to the cytoplasm, of unspliced and singly spliced transcripts coding for structural and nonstructural viral proteins. This process is spatially and temporally coordinated resulting from the interactions between cellular and viral proteins. Here we examined the effects of the sub-cellular localization and dynamics of Rev on the efficiency of nucleocytoplasmic transport of HIV-1 Gag transcripts and virus particle production. Using confocal microscopy and fluorescence recovery after bleaching (FRAP), we report that NF90ctv, a cellular protein involved in Rev function, alters both the sub-cellular localization and dynamics of Rev in vivo, which drastically affects the accumulation of the viral protein p24. The CRM1–dependent nuclear export of Gag mRNA linked to the Rev Response Element (RRE) is dependent on specific domains of the NF90ctv protein. Taken together, our results demonstrate that the appropriate intracellular localization and dynamics of Rev could regulate Gag assembly and HIV-1 replication

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference) and obesity (BMI >2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesit

Temporal and Spatial Trends of Adverse Pregnancy and Birth Outcomes in a Sample of Births from a Public Hospital in Chile

Understanding temporal and spatial trends in pregnancy and birth outcomes within an urban area is important for the monitoring of health indicators of a population. We conducted a retrospective cohort study of all births in the public hospital of Temuco, a medium-sized city in Southern Chile between 2009 and 2016 (n = 17,237). Information on adverse pregnancy and birth outcomes, as well as spatial and maternal characteristics (insurance type, employment, smoking, age, and overweight/obesity), was collected from medical charts. Home addresses were geocoded and assigned to neighborhood. We tested whether births and prevalence of adverse pregnancy outcomes changed over time, whether birth events were spatially clustered (Moran’s I statistic), and whether neighborhood deprivation was correlated to outcomes (Spearman’s rho). We observed decreases in eclampsia, hypertensive disorders of pregnancy, and small for gestational age, while gestational diabetes, preterm birth, and low birth weight increased over the study period (all p < 0.01 for trend), with little changes after adjusting for maternal characteristics. We observed neighborhood clusters for birth rate, preterm birth, and low birth weight. Neighborhood deprivation was negatively correlated with low birth weight and preterm birth, but not correlated with eclampsia, preeclampsia, hypertensive disorders of pregnancy, small for gestational age, gestational diabetes, nor stillbirth. Several encouraging downward trends and some increases in adverse pregnancy and birth outcomes, which, overall, were not explained by changes in maternal characteristics were observed. Identified clusters of higher adverse birth outcomes may be used to evaluate preventive health coverage in this setting

América Latina y el mundo : exploraciones en torno a identidades, discursos y genealogías

América Latina y el Mundo reúne una selección de artículos elaborados a partir de un grupo de ponencias expuestas en las IV Jornadas de Estudiantes de Postgrado en Humanidades, Artes y Ciencias Sociales, realizadas entre el 13 y el 15 de enero del 2003 en la Facultad de Filosofía y Humanidades de la Universidad de Chile. En los artículos reunidos en este volumen se puede reconocer una actitud crítica frente a la hegemonía de los modelos metropolitanos, aunada a esfuerzos destinados a rescatar las actividades, historias y saberes invisibilizados o bien tergiversados por las retóricas y prácticas dominantes en los proyectos modernizadores. Dentro de estas posturas críticas es posible distinguir tres principales líneas temáticas, tales como la reflexión en torno a las identidades, la discusión sobre los modelos de representación y la necesidad de establecer líneas genealógicas que han sido ignoradas por la historiografía tradicional