An Attention-based Bidirectional LSTM Model for Continuous Cross-subject Estimation of Knee Joint Angle during Running from sEMG Signals

Running is an essential locomotion activity that plays a critical role in everyday life and exercise activities and may be impeded by joint disease and neurological impairments. Accurate and robust estimation of joint kinematics via surface electromyogram (sEMG) signals provides a human-machine interaction-based method that can be used to adequately control rehabilitation robots while performing complex movements such as running for motor function restoration in affected persons. To this end, this paper proposes a novel deep learning-based model (AM-BiLSTM) that integrates an attention mechanism (AM) and a bidirectional long short-term memory (BiLSTM) network. The proposed method was evaluated using knee joint kinematic and sEMG signals of fourteen subjects who performed running at 2 m/s speed. The proposed model’s generalizability was tested for within- and cross-subject scenarios and compared with standard LSTM and multi-layer perceptron (MLP) networks in terms of normalized root-mean-square error and correlation coefficient evaluation metrics. Based on the statistical tests, the proposed AM-BiLSTM model significantly outperformed the LSTM and MLP methods in both within- and cross-subject scenarios (p<0.05) and achieved state-of-the-art performance. © 20XX IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works

Enhanced Deep Transfer Learning Model based on Spatial-Temporal driven Scalograms for Precise Decoding of Motor Intent in Stroke Survivors

Motor function loss greatly impacts post-stroke survivors while performing activities of daily living. In the recent years, intelligent rehabilitation robotics have been proposed to enable the patients recover their lost limb functions. Besides, a large proportion of these robots function in passive mode that only allow users to navigate trajectories that rarely align with their limb movement intent, thus precluding full functional recovery. A potential solution would be to explore utilizing an efficient Transfer Learning based Convolutional Neural Network (TL-CNN) to decode multiple classes of post-stroke patients’ motion intentions towards realizing dexterously active robotic training during rehabilitation. In this regard, we propose and examined for the first time, the use of Spatial-Temporal Descriptor based Continuous Wavelet Transform (STD-CWT) as input to TL-CNN to optimally decode limb movement intent patterns of stroke patients to provide adequate input for active motor training in rehabilitation robots. Importantly, we examined the proposed (STD-CWT) method on three distinct wavelets including the Morse, Amor, and Bump, and compared their decoding outcomes with those of the commonly adopted CWT technique under similar experimental conditions. Our method was validated using electromyogram signals of five stroke survivors who performed up to twenty-two distinct limb motions. The obtained results showed that the proposed technique recorded a significantly higher decoding (p<0.05) and converges faster compared to the commonly adopted method. The proposed method equally recorded obvious class separability for individual movement classes across the stroke patients. Findings from this study suggest that the STD-CWT Scalograms would provide potential inputs for robust decoding of motor intent that may facilitate intuitively active motor training in stroke rehabilitation robots. © 20XX IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works

An efficient attention-driven deep neural network approach for continuous estimation of knee joint kinematics via sEMG signals during running

The smooth interaction and coordination between lower-limb amputees and their prosthetics is crucial when performing complex tasks such as running. To address this, simultaneous and proportional control (SPC) based on continuous estimation of joint angles through surface electromyogram (sEMG) signals offers a more seamless interaction between users and their prosthetic limbs than conventional pattern recognition-based control, which relies on recognizing pre-defined movement classes from specific sEMG patterns using classification algorithms. This study proposes a deep learning-based model (AM-BiLSTM) that integrates the attention mechanism (AM) and bidirectional long short-term memory (BiLSTM) network to provide an accurate and robust SPC for estimating knee joint angle during running from a minimal number of sEMG sensors. The sEMG signals of four muscles recorded from 14 subjects during treadmill running at various speeds were utilized by the AM-BiLSTM model to decode knee joint kinematics. To comprehensively investigate the generalizability of the proposed model, it was tested in intra-subject and speed, intra-subject and inter-speed, and inter-subject and speed scenarios and compared with BiLSTM, standard LSTM, and multi-layer perceptron (MLP) approaches. Normalized root-mean-square error and correlation coefficient were used as performance metrics. According to nonparametric statistical tests, the proposed AM-BiLSTM model significantly outperformed the BiLSTM network as well as classical techniques including LSTM and MLP networks in all three experiments (p-value < 0.05) and achieved state-of-the-art performance. Based on our findings, the AM-BiLSTM model may facilitate the deployment of intuitive user-driven deep learning-based control schemes for a wide variety of miniaturized robotic lower-limb devices, including myoelectric prostheses

Poloxamer: A versatile tri-block copolymer for biomedical applications

Poloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers containing central hydrophobic chains of poly(propylene oxide) sandwiched between two hydrophilic chains of poly(ethylene oxide). Some chemical characteristics of poloxamers such as temperature-dependent self-assembly and thermo-reversible behavior along with biocompatibility and physiochemical properties make poloxamer-based biomaterials promising candidates for biomedical application such as tissue engineering and drug delivery. The microstructure, bioactivity, and mechanical properties of poloxamers can be tailored to mimic the behavior of various types of tissues. Moreover, their amphiphilic nature and the potential to self-assemble into the micelles make them promising drug carriers with the ability to improve the drug availability to make cancer cells more vulnerable to drugs. Poloxamers are also used for the modification of hydrophobic tissue-engineered constructs. This article collects the recent advances in design and application of poloxamer-based biomaterials in tissue engineering, drug/gene delivery, theranostic devices, and bioinks for 3D printing. Statement of significance: Poloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers containing central hydrophobic chains of poly(propylene oxide) sandwiched between two hydrophilic chains of poly(ethylene oxide). The microstructure, bioactivity, and mechanical properties of poloxamers can be tailored to mimic the behavior of various types of tissues. Moreover, their amphiphilic nature and the potential to self-assemble into the micelles make them promising drug carriers with the ability to improve the drug availability to make cancer cells more vulnerable to drugs. However, no reports have systematically reviewed the critical role of poloxamer for biomedical applications. Research on poloxamers is growing today opening new scenarios that expand the potential of these biomaterials from �traditional� treatments to a new era of tissue engineering. To the best of our knowledge, this is the first review article in which such issue is systematically reviewed and critically discussed in the light of the existing literature. © 2020 Acta Materialia Inc