The simulation model of the computer cluster

Simulation is often used in cases when it is impossible to carry out experiments with real complex objects. The article represents the description of the computer cluster simulation model. Parameters, which affect the cluster performance, were selected, a simulation model was designed, and experiments were conducted. The obtained model allowed finding the optimal variant of the cluster performance, which consists of five computers

Визуализация индивидуальных данных студента путем применения современных интернет-сервисов

This article gives the analyze of Internet-services, that provide the opportunity to monitor student's achievements and professional development. The aim of this analyze is to choose the one which will be the most appropriate when we evaluate and compare students abilities.В данной статье проводится анализ интернет-сервисов, позволяющих осуществлять мониторинг достижений и профессионального роста студентов, с целью использования выбранного сервиса при оценке компетенций учащихся

Проведение оценки компетенций студентов с применением Интернет-технологий

The article is concerned with different Internet-technologies which can be implemented to facilitate support and development of project activity in Tomsk Polytechnic University by automation of students' competencies evaluation process and selection of most appropriate projects for them.В статье рассматриваются различные Интернет-технологии, внедрение которых может способствовать развитию проектной деятельности на примере Томского политехнического университета путем автоматизации процесса оценки компетенций студентов и подбора наиболее подходящих для них проектов

Digital Horizons in Teacher Education Development

Modern global challenges reflect the essential features of the Fourth Industrial Revolution and are directly related to the digital transformation of life. The teachers are obliged to master the relevant competences to meet the challenges, as their teaching practices experience significant transformations through the enrichment with the digital component. The current problems in the education system transformation force the researchers to identify the principle transformation characteristics, acquire some new types of pedagogical action and design new teacher education formats. The paper presents the authors’ vision of the new teacher education formats at the target, organizational, activity and technological levels. The authors analyze the regional experience of modernization in the higher pedagogical education on the basis of Federal Standards in Higher Education 3++ at the bachelor and master program levels. The realization experience of the federal project “Modern Digital Educational Environment in the Russian Federation” as a part of the national project “Education” is conceptualized in terms of professional skill enhancement of pedagogical personnel in the Tomsk region. The authors reflect on the development trend of the region research and academic complex in the concept of cooperation and resource consolidation for the “Big University” model. The guidelines for strategic development of Tomsk State Pedagogical University, associated with its digitalization, are outlined. The paper shows the development conditions in the digital transformation of the national system for continuous pedagogical education. The paper materials are based on such research methods as theoretical analysis, expert method, and survey

Antioxydant and prooxydant effects of arbutin and hydrohinon in experiment in vitro

The object of research is to compare antioxidant and prooxydant activity of arbutin and hydrochinon in vitro. Antioxidant and prooxydant activity of arbutin and hydrochinon is estimed of their ability to suppress/ induct oxydation ТВИН-80. Arbutin and hydrochinon have antioxydant and prooxydant properties. The conclusions are, that hydrochinon is more antioxydant, arbutin is more prooxydant

Chemistry of lipid A: at the heart of innate immunity

In many Gram-negative bacteria, lipopolysaccharide (LPS) and its lipid A moiety are pivotal for bacterial survival. Depending on its structure, lipid A carries the toxic properties of the LPS and acts as a potent elicitor of the host innate immune system via the Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD-2) receptor complex. It often causes a wide variety of biological effects ranging from a remarkable enhancement of the resistance to the infection to an uncontrolled and massive immune response resulting in sepsis and septic shock. Since the bioactivity of lipid A is strongly influenced by its primary structure, a broad range of chemical syntheses of lipid A derivatives have made an enormous contribution to the characterization of lipid A bioactivity, providing novel pharmacological targets for the development of new biomedical therapies. Here, we describe and discuss the chemical aspects regarding lipid A and its role in innate immunity, from the (bio)synthesis, isolation and characterization to the molecular recognition at the atomic level

ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System

Activation of transcription factor NF-κB is a hallmark of infection with the gastric pathogen Helicobacter pylori, associated with inflammation and carcinogenesis. Genome-wide RNAi screening revealed numerous host factors involved in H. pylori-, but not IL-1β- and TNF-α-dependent NF-κB regulation. Pathway analysis including CRISPR/Cas9-knockout and recombinant protein technology, immunofluorescence microscopy, immunoblotting, mass spectrometry, and mutant H. pylori strains identified the H. pylori metabolite D-glycero-β-D-manno-heptose 1,7-bisphosphate (βHBP) as a cagPAI type IV secretion system (T4SS)-dependent effector of NF-κB activation in infected cells. Upon pathogen-host cell contact, TIFA forms large complexes (TIFAsomes) including interacting host factors, such as TRAF2. NF-κB activation, TIFA phosphorylation, and TIFAsome formation depend on a functional ALPK1 kinase, highlighting the ALPK1-TIFA axis as a core innate immune pathway. ALPK1-TIFA-mediated NF-κB activation was independent of CagA protein translocation, indicating that CagA translocation and HBP delivery to host cells are distinct features of the pathogen’s T4SS