Circulating microRNAs as novel biomarkers for diabetes mellitus.

Diabetes mellitus is characterized by insulin secretion from pancreatic β cells that is insufficient to maintain blood glucose homeostasis. Autoimmune destruction of β cells results in type 1 diabetes mellitus, whereas conditions that reduce insulin sensitivity and negatively affect β-cell activities result in type 2 diabetes mellitus. Without proper management, patients with diabetes mellitus develop serious complications that reduce their quality of life and life expectancy. Biomarkers for early detection of the disease and identification of individuals at risk of developing complications would greatly improve the care of these patients. Small non-coding RNAs called microRNAs (miRNAs) control gene expression and participate in many physiopathological processes. Hundreds of miRNAs are actively or passively released in the circulation and can be used to evaluate health status and disease progression. Both type 1 diabetes mellitus and type 2 diabetes mellitus are associated with distinct modifications in the profile of miRNAs in the blood, which are sometimes detectable several years before the disease manifests. Moreover, circulating levels of certain miRNAs seem to be predictive of long-term complications. Technical and scientific obstacles still exist that need to be overcome, but circulating miRNAs might soon become part of the diagnostic arsenal to identify individuals at risk of developing diabetes mellitus and its devastating complications

Nonlinearity and Topology

The interplay of nonlinearity and topology results in many novel and emergent properties across a number of physical systems such as chiral magnets, nematic liquid crystals, Bose-Einstein condensates, photonics, high energy physics, etc. It also results in a wide variety of topological defects such as solitons, vortices, skyrmions, merons, hopfions, monopoles to name just a few. Interaction among and collision of these nontrivial defects itself is a topic of great interest. Curvature and underlying geometry also affect the shape, interaction and behavior of these defects. Such properties can be studied using techniques such as, e.g. the Bogomolnyi decomposition. Some applications of this interplay, e.g. in nonreciprocal photonics as well as topological materials such as Dirac and Weyl semimetals, are also elucidated

An Ising machine based on networks of subharmonic electrical resonators

Combinatorial optimization problems are difficult to solve with conventional algorithms. Here we explore networks of nonlinear electronic oscillators evolving dynamically towards the solution to such problems. We show that when driven into subharmonic response, such oscillator networks can minimize the Ising Hamiltonian on non-trivial antiferromagnetically-coupled 3-regular graphs. In this context, the spin-up and spin-down states of the Ising machine are represented by the oscillators’ response at the even or odd driving cycles. Our experimental setting of driven nonlinear oscillators coupled via a programmable switch matrix leads to a unique energy minimizer when one exists, and probes frustration where appropriate. Theoretical modeling of the electronic oscillators and their couplings allows us to accurately reproduce the qualitative features of the ex- perimental results and extends the results to larger graphs. This suggests the promise of this setup as a prototypical one for exploring the capabilities of such an unconventional computing platform.JSF-19-02-0005, DMS-1809074, PHY-2110030, NPIF EPSRC Doctoral grant EP/R512461/