Occupational differences in healthcare : a categorization in terms of personality dispositions

This personality study on organizational psychology examines different attitudes demonstrated by different occupational work groups towards situational characteristics and namely those within the context of Performance Management (PM), a management tool charting agreed objectives in a work plan, monitoring progress of, and providing feedback to each individual employee in the achievement of these objectives, which may be linked to a reward. Contrary to the traditional school which advocates that situational characteristics cause predictable behaviour across individuals, the main focus is therefore the dispositional approach, although this perspective does not negate situational effects. The attitudes towards the eventual roll out of a Performance Management Plan (PMP) in St. Luke's Hospital are investigated. The organization under investigation was seen to provide suitable ground for conducting the study because of the heterogeneity of work groups involving professional and other ancillary workers. The categorization of attitudes employed a number of personality disposition indices, including Locus of control (LOC), Goal orientation (GO) and Self efficacy (SE). The bipolar nature of these constructs enabled most of the answers to the items used in the questionnaire to be coded along a scale. Quantitatively, the occupation variable emerged as one of the most important variable out of all the biographical variables under study, when correlated with the personality variables. Both quantitative and qualitative analyses indicate a qualified clustering of the professions in terms of personality traits, compared with the ancillary group. The LOC variable emerged as the most consistent of all the constructs under study both cross-sectionally amongst the various occupations under study and also vertically within the same occupation. This paper argues that this personality variable may relate to previous literature exploring the strategies and struggles over boundaries between a profession and other groups where power is contested.peer-reviewe

Social cases?

This was a cross-sectional descriptive study of in-patients over the age of 60 years at St. Luke's hospital who were deemed to be social cases (SC). The majority (58.4%) were female and the mean age was 80 years (range 60-92, SD: 6.7 years). Most (80%) were found in medical wards. The mean length of stay was 22.5 days (range 1-290 days, SD: 36.4 days). Social cases were a frail group with a mean number of co-morbidities of 2.8 (range 0-6, SD:1.5). Dependency level was also high with a mean Barthel score of 6.8 (range 0-20, SD: 7.4). A diagnosis of dementia was documented on the patient's medical record in only 12%. However significant low Abbreviated Mental Test scores were found in 64% (mean AMT 5.0, range 0-9, SD: 2.8). These findings illustrate that most social cases at St. Luke's Hospital are not only there for `social' reasons but also have other factors involved, including a high dependency level in activities of daily living which hamper their discharge to the community. Rehabilitation using an interdisciplinary approach may help the less dependent return to the community.peer-reviewe

Adult education in small states : the case of Malta

A small state faces several challenges with regard to adult continuing education and training. The paper discusses some of these challenges with specific reference to the Mediterranean small island state of Malta. It starts with a general discussion of some of the issues affecting adult education in a small state such as Malta that paves the way for the more focused analyses in the second and third sections. These sections focus on a selection of just two topics from among the many that affect adult education in Malta, namely those of adult education and work and adult education for sustainable development. These analyses are tackled from the perspective of the small state condition.peer-reviewe

Orthogeriatrics in Malta : a 3 year experience

The orthogeriatric service in Malta started in 2012 and expanded in 2014. From admission, the patient is offered a ward based hip fracture programme that includes orthogeriatric assessment, management and co-ordinated multidisciplinary review. 457 patients were seen by the orthogeriatric service when this study was done. Mean age was 83 and 69% of patients were female. The Nottingham Hip Fracture Score (NHFS) is a scoring system that reliably predicts 30-day and 1-year mortality for patients after hip fracture. It is made up of seven independent predictors of postoperative mortality that have been incorporated into a risk score. The score ranges from 0-10 and the mean score for this cohort was 5.1. There was a statistically significant correlation between age and high NHFS scores. 30 day mortality was 5.9% and 1 year mortality was 24.4%. Compared with the Nottingham data both 30 day and 1 year mortality were less for the orthogeriatric department in Malta. The orthogeriatric service in Malta achieved better results when comparing mortality with the UK. In the future expansion of data collected should be considered to better evaluate standards of care in the department.peer-reviewe

The muscle satellite cell at 50: the formative years

In February 1961, Alexander Mauro described a cell 'wedged' between the plasma membrane of the muscle fibre and the surrounding basement membrane. He postulated that it could be a dormant myoblast, poised to repair muscle when needed. In the same month, Bernard Katz also reported a cell in a similar location on muscle spindles, suggesting that it was associated with development and growth of intrafusal muscle fibres. Both Mauro and Katz used the term 'satellite cell' in relation to their discoveries. Today, the muscle satellite cell is widely accepted as the resident stem cell of skeletal muscle, supplying myoblasts for growth, homeostasis and repair

Exploring the Opportunities of Generative Artificial Intelligence in Concept Ship Design

Designing vessels is a complex process requiring the consideration of numerous aspects to develop a successful design. Ship and submarine design often requires the designer to approximate, make assumptions, consider scenarios and imagine how the vessel may be used in operation. Having the ability to consult for feedback or request additional information may be a welcome aid. The onset of Generative AI (GENAI) presents a new opportunity to integrate this resource into the workflows of the concept ship design process. Augmenting the design process could have a positive impact on the outcome of the design, further improving various qualities such as performance, sustainability, equality, diversity and inclusion. Aspects associated with weight groups, payload catalogues, technical analysis and layout set out will be explored to investigate whether GENAI could add value to the design process. A case study will be used to facilitate this investigation, taking note of GENAI’s content throughout the process

Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling

Adult skeletal muscle is able to repeatedly regenerate because of the presence of satellite cells, a population of stem cells resident beneath the basal lamina that surrounds each myofiber. Little is known, however, of the signaling pathways involved in the activation of satellite cells from quiescence to proliferation, a crucial step in muscle regeneration. We show that sphingosine-1-phosphate induces satellite cells to enter the cell cycle. Indeed, inhibiting the sphingolipid-signaling cascade that generates sphingosine-1-phosphate significantly reduces the number of satellite cells able to proliferate in response to mitogen stimulation in vitro and perturbs muscle regeneration in vivo. In addition, metabolism of sphingomyelin located in the inner leaflet of the plasma membrane is probably the main source of sphingosine-1-phosphate used to mediate the mitogenic signal. Together, our observations show that sphingolipid signaling is involved in the induction of proliferation in an adult stem cell and a key component of muscle regeneration

Dynamics of muscle fibre growth during postnatal mouse development

<p>Abstract</p> <p>Background</p> <p>Postnatal growth in mouse is rapid, with total skeletal muscle mass increasing several-fold in the first few weeks. Muscle growth can be achieved by either an increase in muscle fibre number or an increase in the size of individual myofibres, or a combination of both. Where myofibre hypertrophy during growth requires the addition of new myonuclei, these are supplied by muscle satellite cells, the resident stem cells of skeletal muscle.</p> <p>Results</p> <p>Here, we report on the dynamics of postnatal myofibre growth in the mouse extensor digitorum longus (EDL) muscle, which is essentially composed of fast type II fibres in adult. We found that there was no net gain in myofibre number in the EDL between P7 and P56 (adulthood). However, myofibre cross-sectional area increased by 7.6-fold, and length by 1.9-fold between these ages, resulting in an increase in total myofibre volume of 14.1-fold: showing the extent of myofibre hypertrophy during the postnatal period. To determine how the number of myonuclei changes during this period of intense muscle fibre hypertrophy, we used two complementary mouse models: <it>3F-nlacZ-E </it>mice express <it>nlacZ </it>only in myonuclei, while <it>Myf5</it>^{<it>nlacZ</it>/+}mice have β-galactosidase activity in satellite cells. There was a ~5-fold increase in myonuclear number per myofibre between P3 and P21. Thus myofibre hypertrophy is initially accompanied by a significant addition of myonuclei. Despite this, the estimated myonuclear domain still doubled between P7 and P21 to 9.2 × 10³μm³. There was no further addition of myonuclei from P21, but myofibre volume continued to increase, resulting in an estimated ~3-fold expansion of the myonuclear domain to 26.5 × 10³μm³by P56. We also used our two mouse models to determine the number of satellite cells per myofibre during postnatal growth. Satellite cell number in EDL was initially ~14 satellite cells per myofibre at P7, but then fell to reach the adult level of ~5 by P21.</p> <p>Conclusions</p> <p>Postnatal fast muscle fibre type growth is divided into distinct phases in mouse EDL: myofibre hypertrophy is initially supported by a rapid increase in the number of myonuclei, but nuclear addition stops around P21. Since the significant myofibre hypertrophy from P21 to adulthood occurs without the net addition of new myonuclei, a considerable expansion of the myonuclear domain results. Satellite cell numbers are initially stable, but then decrease to reach the adult level by P21. Thus the adult number of both myonuclei and satellite cells is already established by three weeks of postnatal growth in mouse.</p

Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy

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