A Review on Interlocking Compressed Earth Blocks (ICEB) with Addition of Bacteria

Interlocking Compressed Earth Block (ICEB) are cement stabilized soil blocks that allow for dry stacked construction. Because of this characteristic, the process of building walls is faster and requires less skilled labour as the blocks are laid dry and lock into place. However there are plenty room for improving the interlocking blocks by increase its durability. Durability of bricks are affected by several factors and one of them are water absorption. High water absorption level will results in low durability. Many studies have been conducted in order to improve the durability of bricks by using environmentally method. One of the method is by inducing bacteria into bricks. Bacteria in brick induced calcite precipitation (calcite crystals) to cover the cracks continuously. Therefore, the issues of durability of bricks can be fully solved. This paper offer a review on interlocking compressed earth blocks and the use of bacteria in reducing water absorption level

A Review on Interlocking Compressed Earth Blocks (ICEB) with Addition of Bacteria

Interlocking Compressed Earth Block (ICEB) are cement stabilized soil blocks that allow for dry stacked construction. Because of this characteristic, the process of building walls is faster and requires less skilled labour as the blocks are laid dry and lock into place. However there are plenty room for improving the interlocking blocks by increase its durability. Durability of bricks are affected by several factors and one of them are water absorption. High water absorption level will results in low durability. Many studies have been conducted in order to improve the durability of bricks by using environmentally method. One of the method is by inducing bacteria into bricks. Bacteria in brick induced calcite precipitation (calcite crystals) to cover the cracks continuously. Therefore, the issues of durability of bricks can be fully solved. This paper offer a review on interlocking compressed earth blocks and the use of bacteria in reducing water absorption level

Influence of Ureolytic Bacteria Toward Interlocking Compressed Earth Blocks (ICEB) in Improving Durability of ICEB

Interlocking compressed earth blocks (ICEB) are soil stabilized based blocks that allows for mortarless construction. Various studies have been conducted to improve the durability of bricks by using environmental friendly solution. This is because common method used by the construction industries generally involving the use of chemical based substances which will promote pollution to the surrounding. This paper provide the results of Ureolytic Bacteria (UB) in improving the compressive strength and water absorption properties with the percentage of 1%, 3% and 5% UB for 7th ,14th and 28th days of testing. The bacteria were added as partial replacement of limestone water in ICEB. The results of compressive strength and water absorption show that the increment of 15.25% strength and reduction of 15.66% water absorption with 5% of UB on the 28th days of testing compared to the control specimen. Therefore it is hoped that the positive results on using bacteria will continue to improve the durability of the ICEB as one of the environmental friendly solution in order to achieve sustainable construction

Influence of Ureolytic Bacteria Toward Interlocking Compressed Earth Blocks (ICEB) in Improving Durability of ICEB

Interlocking compressed earth blocks (ICEB) are soil stabilized based blocks that allows for mortarless construction. Various studies have been conducted to improve the durability of bricks by using environmental friendly solution. This is because common method used by the construction industries generally involving the use of chemical based substances which will promote pollution to the surrounding. This paper provide the results of Ureolytic Bacteria (UB) in improving the compressive strength and water absorption properties with the percentage of 1%, 3% and 5% UB for 7th ,14th and 28th days of testing. The bacteria were added as partial replacement of limestone water in ICEB. The results of compressive strength and water absorption show that the increment of 15.25% strength and reduction of 15.66% water absorption with 5% of UB on the 28th days of testing compared to the control specimen. Therefore it is hoped that the positive results on using bacteria will continue to improve the durability of the ICEB as one of the environmental friendly solution in order to achieve sustainable construction

Systems biology analysis of human genomes points to key pathways conferring spina bifida risk

Spina bifida (SB) is a debilitating birth defect caused by multiple gene and environment interactions. Though SB shows non-Mendelian inheritance, genetic factors contribute to an estimated 70% of cases. Nevertheless, identifying human mutations conferring SB risk is challenging due to its relative rarity, genetic heterogeneity, incomplete penetrance, and environmental influences that hamper genome-wide association studies approaches to untargeted discovery. Thus, SB genetic studies may suffer from population substructure and/or selection bias introduced by typical candidate gene searches. We report a population based, ancestry-matched whole-genome sequence analysis of SB genetic predisposition using a systems biology strategy to interrogate 298 case-control subject genomes (149 pairs). Genes that were enriched in likely gene disrupting (LGD), rare protein-coding variants were subjected to machine learning analysis to identify genes in which LGD variants occur with a different frequency in cases versus controls and so discriminate between these groups. Those genes with high discriminatory potential for SB significantly enriched pathways pertaining to carbon metabolism, inflammation, innate immunity, cytoskeletal regulation, and essential transcriptional regulation consistent with their having impact on the pathogenesis of human SB. Additionally, an interrogation of conserved noncoding sequences identified robust variant enrichment in regulatory regions of several transcription factors critical to embryonic development. This genome-wide perspective offers an effective approach to the interrogation of coding and noncoding sequence variant contributions to rare complex genetic disorders

Systems biology analysis of human genomes points to key pathways conferring spina bifida risk

Spina bifida (SB) is a debilitating birth defect caused by multiple gene and environment interactions. Though SB shows non-Mendelian inheritance, genetic factors contribute to an estimated 70% of cases. Nevertheless, identifying human mutations conferring SB risk is challenging due to its relative rarity, genetic heterogeneity, incomplete penetrance, and environmental influences that hamper genome-wide association studies approaches to untargeted discovery. Thus, SB genetic studies may suffer from population substructure and/or selection bias introduced by typical candidate gene searches. We report a population based, ancestry-matched whole-genome sequence analysis of SB genetic predisposition using a systems biology strategy to interrogate 298 case-control subject genomes (149 pairs). Genes that were enriched in likely gene disrupting (LGD), rare protein-coding variants were subjected to machine learning analysis to identify genes in which LGD variants occur with a different frequency in cases versus controls and so discriminate between these groups. Those genes with high discriminatory potential for SB significantly enriched pathways pertaining to carbon metabolism, inflammation, innate immunity, cytoskeletal regulation, and essential transcriptional regulation consistent with their having impact on the pathogenesis of human SB. Additionally, an interrogation of conserved noncoding sequences identified robust variant enrichment in regulatory regions of several transcription factors critical to embryonic development. This genome-wide perspective offers an effective approach to the interrogation of coding and noncoding sequence variant contributions to rare complex genetic disorders