Dye diffusion during laparoscopic tubal patency tests may suggest a lymphatic contribution to dissemination in endometriosis: A prospective, observational study

Aim Women with adenomyosis are at higher risk of endometriosis recurrence after surgery. This study was to assess if the lymphatic vessel network drained from the uterus to near organs where endometriosis foci lied. Methods A prospective, observational study, Canadian Task Force Classification II-2, was conducted at Sacro Cuore Don Calabria Hospital, Negrar, Italy. 104 white women aged 18–43 years were enrolled consecutively for this study. All patients underwent laparoscopy for endometriosis and a tubal dye test was carried out. Results Evidence of dye dissemination through the uterine wall and outside the uterus was noted in 27 patients (26%) with adenomyosis as it permeated the uterine wall and a clear passage of the dye was shown in the pelvic lymphatic vessels regardless whether the tubes were unobstructed. Histological assessment of the uterine biopsies confirmed adenomyosis. Conclusion Adenomyosis is characterized by ectatic lymphatics that allow the drainage of intrauterine fluids (the dye and, perhaps, menstrual blood) at minimal intrauterine pressure from the uterine cavity though the lymphatic network to extrauterine organs. Certainly, this may not be the only explanation for endometriosis dissemination but the correlation between the routes of the dye drainage and location of endometriosis foci is highly suggestive

Multidimensional virtual globe for geo big data visualization

In this paper, we presented a web application created using the NASA WebWorldWind framework. The application is capable of visualizing n-dimensional data using a Voxel model. In this case study, we handled social media data and Call Detailed Records (CDR) of telecommunication networks. These were retrieved from the "BigData Challenge 2015" of Telecom Italia. We focused on the visualization process for a suitable way to show this geo-data in a 3D environment, incorporating more than three dimensions. This engenders an interactive way to browse the data in their real context and understand them quickly. Users will be able to handle several varieties of data, import their dataset using a particular data structure, and then mash them up in the WebWorldWind virtual globe. A broad range of public use this tool for diverse purposes is possible, without much experience in the field, thanks to the intuitive user-interface of this web app

Impaired Self-Awareness in Parkinson’s and Huntington’s Diseases: A Literature Review of Neuroimaging Correlates

Little is known about the brain correlates of anosognosia or unawareness of disease in Parkinson's Disease (PD) and Huntington's Disease (HD). The presence of unawareness or impaired self-awareness (ISA) of illness has profound implications for patients and their caregivers; therefore, studying awareness and its brain correlates should be considered a key step towards developing effective recognition and management of this symptom as it offers a window into the mechanism of self-awareness and consciousness as critical components of the human cognition. We reviewed research studies adopting MRI or other in vivo neuroimaging technique to assess brain structural and/or functional correlates of unawareness in PD and HD across different cognitive and motor domains. Studies adopting task or resting-state functional magnetic resonance imaging, and/or 18-F fluorodeoxyglucose positron emission tomography brain imaging and/or magnetic resonance imaging structural measures were considered. Only six studies investigating neuroimaging features of unawareness in PD and two in HD were identified; there was great heterogeneity in the clinical characteristics of the study participants, domain of unawareness investigated, method of unawareness assessment, and neuroimaging technique used. Nevertheless, some data converge in identifying regions of the salience and frontoparietal networks to be associated with unawareness in PD patients. In HD, the few data are affected by the variability in the severity of motor symptoms. Further studies are needed to better understand the mechanisms and brain correlates of unawareness in PD and HD; in addition, the use of dopaminergic medications should be carefully considered

From paper maps to the Digital Earth and the Internet of Places

Maps have always been tools that have fascinated men, for their ability to make us see the world that surrounds us. They were and are the outcome of models and methods applied to the observation of the world, starting from geodesy, surveying photogrammetry and remote sensing. All these disciplines, which we now group under the new name of geomatics, have had a tremendous boost in recent years. However, the synergy with information computer technology is probably the aspect that is revolutionizing more cartography. Earlier computers and after the Internet have brought us to new concepts and tools that will have profound effects not only in the world of niche of cartographers, but also more generally in the life of all human beings. The Digital Earth, proposed in 1998 by Al Gore, has been enriched in just twenty years of a set of new demands, which make even more interesting and challenging being cartographers today. The paper, without claiming to be comprehensive, aims at providing a concise overview of the state of art and of the advancement in this area. Moreover, it urges the community of geomatics to be protagonist and promoter of a new cartography, largely to be reinvented, and that would put us at the center of processes of knowledge and management of the Earth. The map makers in the past helped discovering new worlds, now the challenge is to rediscover our common world with new eyes of environmental, social, economic equity, sustainability and participation

A NEW MULTI-RESOLUTION ALGORITHM TO STORE AND TRANSMIT COMPRESSED DTM

WebGIS and virtual globes allow DTMs distribution and three dimensional representations to the Web users' community. In these applications, the database storage size represents a critical point. DTMs are obtained by some sampling or interpolation on the raw observations and typically are stored and distributed by data based models, like for example regular grids. A new approach to store and transmit DTMs is presented. The idea is to use multi-resolution bilinear spline functions to interpolate the observations and to model the terrain. More in detail, the algorithm performs the following actions. 1) The spatial distribution of the observations is investigated. Where few data are available, few levels of splines are activated while more levels are activated where the raw observations are denser: each new level corresponds to an halving of the spline support with respect to the previous level. 2) After the selection of the spline functions to be activated, the relevant coefficients are estimated by interpolating the observations. The interpolation is computed by batch least squares. 3) Finally, the estimated coefficients of the splines are stored. The model guarantees a local resolution consistent with the data density and can be defined analytical, because the coefficients of a given function are stored instead of a set of heights. The approach is discussed and compared with the traditional techniques to interpolate, store and transmit DTMs, considering accuracy and storage requirements. It is also compared with another multi-resolution technique. The research has been funded by the INTERREG HELI-DEM (Helvetia Italy Digital Elevation Model) project

Participatory GIS: experimentations for a 3D social virtual globe

The dawn of GeoWeb 2.0, the geographic extension of Web 2.0, has opened new possibilities in terms of online dissemination and sharing of geospatial contents, thus laying the foundations for a fruitful development of Participatory GIS (PGIS). The purpose of the study is to investigate the extension of PGIS applications, which are quite mature in the traditional bi-dimensional framework, up to the third dimension. More in detail, the system should couple a powerful 3D visualization with an increase of public participation by means of a tool allowing data collecting from mobile devices (e.g. smartphones and tablets). The PGIS application, built using the open source NASA World Wind virtual globe, is focussed on the cultural and tourism heritage of Como city, located in Northern Italy. An authentication mechanism was implemented, which allows users to create and manage customized projects through cartographic mash-ups of Web Map Service (WMS) layers. Saved projects populate a catalogue which is available to the entire community. Together with historical maps and the current cartography of the city, the system is also able to manage geo-tagged multimedia data, which come from user field-surveys performed through mobile devices and report POIs (Points Of Interest). Each logged user can then contribute to POIs characterization by adding textual and multimedia information (e.g. images, audios and videos) directly on the globe. All in all, the resulting application allows users to create and share contributions as it usually happens on social platforms, additionally providing a realistic 3D representation enhancing the expressive power of data

A Dtm Multi-Resolution Compressed Model for Efficient Data Storage and Network Transfer

In recent years the technological evolution of terrestrial, aerial and satellite surveying, has considerably increased the measurement accuracy and, consequently, the quality of the derived information. At the same time, the smaller and smaller limitations on data storage devices, in terms of capacity and cost, has allowed the storage and the elaboration of a bigger number of instrumental observations. A significant example is the terrain height surveyed by LIDAR (LIght Detection And Ranging) technology where several height measurements for each square meter of land can be obtained. The availability of such a large quantity of observations is an essential requisite for an in-depth knowledge of the phenomena under study. But, at the same time, the most common Geographical Information Systems (GISs) show latency in visualizing and analyzing these kind of data. This problem becomes more evident in case of Internet GIS. These systems are based on the very frequent flow of geographical information over the internet and, for this reason, the band-width of the network and the size of the data to be transmitted are two fundamental factors to be considered in order to guarantee the actual usability of these technologies. In this paper we focus our attention on digital terrain models (DTM's) and we briefly analyse the problems about the definition of the minimal necessary information to store and transmit DTM's over network, with a fixed tolerance, starting from a huge number of observations. Then we propose an innovative compression approach for sparse observations by means of multi-resolution spline functions approximation. The method is able to provide metrical accuracy at least comparable to that provided by the most common deterministic interpolation algorithms (inverse distance weighting, local polynomial, radial basis functions). At the same time it dramatically reduces the number of information required for storing or for transmitting and rebuilding a digital terrain model dataset. A brief description of the method is presented and comparisons about the accuracy and data-store compression obtained with respect to other interpolators are shown

Harnack inequality and smoothness for quasilinear degenerate elliptic equations

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Harnack inequality and regularity for degenerate quasilinear elliptic equations

We prove Harnack inequality and local regularity results for weak solutions of a quasilinear degenerate equation in divergence form under natural growth conditions. The degeneracy is given by a suitable power of a strong $A_\infty$ weight. Regularity results are achieved under minimal assumptions on the coefficients and, as an application, we prove $C^{1,\alpha}$ local estimates for solutions of a degenerate equation in non divergence form