Corallorhiza odontorhiza Nutt.

https://thekeep.eiu.edu/herbarium_specimens_byname/21290/thumbnail.jp

A phenomenological exploration of how one partner's religious change impacts their couple relationship

Includes bibliographical references

Evaluation of the Coulter Automatic Particle Counter

Mechanical Engineerin

Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.

Well-differentiated papillary mesothelioma is an uncommon mesothelial neoplasm that most frequently arises in the peritoneal cavity of women of reproductive age. Whereas malignant mesothelioma is an aggressive tumor associated with poor outcome, well-differentiated papillary mesothelioma typically exhibits indolent behavior. However, histologically differentiating between these two entities can be challenging, necessitating the development of distinguishing biomarkers. While the genetic alterations that drive malignant mesothelioma have recently been determined, the molecular pathogenesis of well-differentiated papillary mesothelioma is unknown. Here we performed genomic profiling on a cohort of ten well-differentiated papillary mesothelioma of the peritoneum. We identified that all tumors harbored somatic missense mutations in either the TRAF7 or CDC42 genes, and lacked alterations involving BAP1, NF2, CDKN2A, DDX3X, SETD2, and ALK that are frequent in malignant mesothelioma. We recently identified that another mesothelial neoplasm, adenomatoid tumor of the genital tract, is genetically defined by somatic missense mutations in the TRAF7 gene, indicating a shared molecular pathogenesis between well-differentiated papillary mesothelioma and adenomatoid tumors. To the best of our knowledge, well-differentiated papillary mesothelioma is the first human tumor type found to harbor recurrent mutations in the CDC42 gene, which encodes a Rho family GTPase. Immunohistochemistry demonstrated intact BAP1 expression in all cases of well-differentiated papillary mesothelioma, indicating that this is a reliable marker for distinguishing well-differentiated papillary mesothelioma from malignant mesotheliomas that frequently display loss of expression. Additionally, all well-differentiated papillary mesothelioma demonstrated robust expression of L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation, similar to that observed in adenomatoid tumors. In contrast, we have previously shown that L1CAM staining is not observed in normal mesothelial cells and malignant mesotheliomas of the peritoneum. Together, these studies demonstrate that well-differentiated papillary mesothelioma is genetically defined by mutually exclusive mutations in TRAF7 and CDC42 that molecularly distinguish this entity from malignant mesothelioma

Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.

Malignant mesothelioma is a rare cancer that arises from the mesothelial cells that line the pleural cavity and less commonly from the peritoneal lining of the abdomen and pelvis. Most pleural mesotheliomas arise in patients with a history of asbestos exposure, whereas the association of peritoneal mesotheliomas with exposure to asbestos and other potential carcinogens is less clear, suggesting that the genetic alterations that drive malignant peritoneal mesothelioma may be unique from those in pleural mesothelioma. Treatment options for all malignant mesotheliomas are currently limited, with no known targeted therapies available. To better understand the molecular pathogenesis of malignant peritoneal mesothelioma, we sequenced 510 cancer-related genes in 13 patients with malignant mesothelioma arising in the peritoneal cavity. The most frequent genetic alteration was biallelic inactivation of the BAP1 gene, which occurred in 9/13 cases, with an additional two cases demonstrating monoallelic loss of BAP1. All 11 of these cases demonstrated loss of BAP1 nuclear staining by immunohistochemistry, whereas two tumors without BAP1 alteration and all 42 cases of histologic mimics in peritoneum (8 multilocular peritoneal inclusion cyst, 6 well-differentiated papillary mesothelioma of the peritoneum, 16 adenomatoid tumor, and 12 low-grade serous carcinoma of the ovary) demonstrated intact BAP1 nuclear staining. Additional recurrently mutated genes in this cohort of malignant peritoneal mesotheliomas included NF2 (3/13), SETD2 (2/13), and DDX3X (2/13). While these genes are known to be recurrently mutated in pleural mesotheliomas, the frequencies are distinct in peritoneal mesotheliomas, with nearly 85% of peritoneal tumors harboring BAP1 alterations versus only 20-30% of pleural tumors. Together, these findings demonstrate the importance of epigenetic modifiers including BAP1, SETD2, and DDX3X in mesothelial tumorigenesis and suggest opportunities for targeted therapies

Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell turnours

Background: Sertoli-Leyclig cell tumours of the ovary account for only 0.2% of malignant ovarian tumours. Two-thirds of all patients become apparent due to the tumour's hormone production. Methods: A 41-year-old patient (gravida 4, para 4) presented with dyspnoea, enlarged abdominal girth and melaena. Diagnostic imaging was suspicious for an ovarian cancer. The standard tumour marker for ovarian cancer (CA 125) was elevated to 984 U/mL. Results: Surgical exploration of the abdomen revealed a mouldering tumour of both adnexes extending to the level of the navel. Frozen sections showed an undifferentiated carcinoma of unknown origin. Radical surgery was performed. The final histological report described a malignant sex-cord stroma tumour, a Sertoli-Leydig cell tumour, emanating from both ovaries. Analysis of preoperative blood serum showed elevated levels of CYFRA 21-1 (10.4 ng/mL), neuron-specific enolase (36.2 ng/mL), oestradiol (485 pg/mL) and CA-125 (984 U/mL). Adjuvant chemotherapy and regional hyperthermia were performed due to the malignant potential and incomplete resection of the tumour. Conclusions: Undifferentiated Sertoli-Leyclig cell tumours show a poor clinical course. As only two-thirds of patients with this rare disease present with elevated hormone levels, new markers deserve further investigation to offer more specific, individualised tumour monitoring

Communicating the Impacts of Potential Future Climate Change on the Expected Frequency of Extreme Rainfall Events in Cook County, Illinois

A novel methodology for determining future rainfall frequency is described in this report. Isohyetal maps illustrate how heavy precipitation may change in the future, but the results have a high level of uncertainty expressed as very wide confidence limits. Uncertainty in possible future conditions is much greater than the uncertainty identified for current commonly used precipitation analyses. The resulting isohyetal maps do not replace existing sources, such as Illinois State Water Survey (ISWS) Bulletin 70 (Huff and Angel, 1989) or National Oceanic and Atmospheric Administration (NOAA) Atlas 14 (Bonnin et al., 2006). Presently, the ISWS is updating Bulletin 70 (Huff and Angel, 1989) for subregions of Illinois. Some of these updates will include projected rainfall frequency. The key objectives of this study are to i) design a framework to translate future climate scenarios into a product that engineers and planners can use to quantify the impact of climate change, and ii) demonstrate how climate model output can be used to inform and plan adaptive strategies for stormwater and floodplain management. The framework in this study is illustrated using the observed and projected rainfall data in Cook County, Illinois, providing a road map to evaluate climate change impacts on urban flooding and a plan for adaptation. Numerous studies attempt to identify the implications of climate change with respect to hydrologic extremes (e.g., IPCC, 2007; CCSP, 2008; Milly et al., 2008). These studies project future climate conditions with more frequent extreme precipitation events in many regions around the world, including parts of the United States. In particular, it has been projected that northeastern Illinois, including the Chicago metropolitan area, will experience more frequent and more intense rainfall events in the future (Markus et al., 2012), which will lead to more intense and more frequent urban flooding events and to increased human, environmental, and economic risks. Thus, various planning and management measures need to be considered by urban communities which are responsible for administering ordinances governing the construction and maintenance of stormwater management systems, and for floodplain management to address public safety concerns, property damage, and economic interruption from intense precipitation. In these efforts, effective communication of climate change impacts on urban watersheds/sewer sheds is needed. Data should be delivered at the watershed level in a form that can be incorporated in watershed planning at the community level. Delivery of useful climate change information is critical for community planning and adaptation to changing climate conditions. It is common practice that future climate projections, which are based on global circulation models (GCM), are downscaled to finer temporal and spatial scales using statistical or dynamical downscaling models. However, watershed-scale climate data generated by climate models still do not provide precipitation data in a format useful for community engineers and planners to prepare, mitigate, and adapt to future conditions. Furthermore, city managers and decision makers need quantifiable future risk to demonstrate the need for adaptive actions, such as retrofitting storm sewers and other water conveyance structures or adopting higher regulatory design standards within the community. This is not offered by the present climate modeling outputs. In this research, a method is designed to analyze and express climate data in a format that can be readily used to assess future extreme precipitation events in models commonly used for sizing stormwater infrastructure and identifying flooding potential. In this method, future conditions climate data are analyzed to prepare precipitation maps for selected design storm frequencies which can be used to model future climate conditions of stormwater runoff and flood risk. This report presents a newly designed research framework to determine future conditions rainfall frequency maps, illustrating it in Cook County, Illinois, for the 24-hour duration rainfall event and for a range of recurrence intervals (also called return periods). Engineers commonly use these maps to determine the appropriate return period rainfall amount by interpolating between the isohyetals to evaluate options for storm and flood water management. Impacts of future climate conditions can then be convincingly demonstrated using conventional engineering to show changes in flooding frequency and extent, as well as damage comparisons associated with changing intense precipitation. Using standard and familiar models with future conditions precipitation scenarios facilitates communication of quantifiable future risk and supports community decision makers so they can plan, mitigate, and adapt to future conditions. This directly supports climate adaptation and mitigation by providing an understandable method for community engineers and planners to demonstrate the impact of climate change at the local level and develop specific adaptation strategies that will reduce future risk.published or submitted for publicationis peer reviewedOpe

Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation.

Adenomatoid tumors are the most common neoplasm of the epididymis, and histologically similar adenomatoid tumors also commonly arise in the uterus and fallopian tube. To investigate the molecular pathogenesis of these tumors, we performed genomic profiling on a cohort of 31 adenomatoid tumors of the male and female genital tracts. We identified that all tumors harbored somatic missense mutations in the TRAF7 gene, which encodes an E3 ubiquitin ligase belonging to the family of tumor necrosis factor receptor-associated factors (TRAFs). These mutations all clustered into one of five recurrent hotspots within the WD40 repeat domains at the C-terminus of the protein. Functional studies in vitro revealed that expression of mutant but not wild-type TRAF7 led to increased phosphorylation of nuclear factor-kappa B (NF-kB) and increased expression of L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation. Immunohistochemistry demonstrated robust L1CAM expression in adenomatoid tumors that was absent in normal mesothelial cells, malignant peritoneal mesotheliomas and multilocular peritoneal inclusion cysts. Together, these studies demonstrate that adenomatoid tumors of the male and female genital tract are genetically defined by TRAF7 mutation that drives aberrant NF-kB pathway activation

The Vehicle, Fall 1973

Table of Contents Just the SameRick Hoblerpage 4 Gentle NightPatricia Christpage 5 Baby Makes TwoMarilyn Beckerpage 5 StephenMarilyn Beckerpage 5 Seventh AlarumKeith Fuerstpage 6 DallasKeith Fuerstpage 6 An Old Floor CandlePeggy Wallacepage 7 Without LoveRod Boehmerpage 7 No TouchJerilyn Jonespage 8 A BeginningJerilyn Jonespage 8 First Frost of AutumnMelvin Zaloudekpage 9 TrisetrieWilliam Uteschpage 9 EyesMarvinetta Woodleypage 9https://thekeep.eiu.edu/vehicle/1030/thumbnail.jp

The Vehicle, Fall 1973

Table of Contents Just the SameRick Hoblerpage 4 Gentle NightPatricia Christpage 5 Baby Makes TwoMarilyn Beckerpage 5 StephenMarilyn Beckerpage 5 Seventh AlarumKeith Fuerstpage 6 DallasKeith Fuerstpage 6 An Old Floor CandlePeggy Wallacepage 7 Without LoveRod Boehmerpage 7 No TouchJerilyn Jonespage 8 A BeginningJerilyn Jonespage 8 First Frost of AutumnMelvin Zaloudekpage 9 TrisetrieWilliam Uteschpage 9 EyesMarvinetta Woodleypage 9https://thekeep.eiu.edu/vehicle/1030/thumbnail.jp