Preliminary investigation of myo-inositol phosphates produced by ASUIA279 phytase on MCF-7 cancer cells.

Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice brans. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 µg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 ?g/ml. The inhibition of MCF-7 was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration

A photobioreactor design for large-scale microalgae cultivation

© 2017 by Nova Science Publishers, Inc. All rights reserved. Microalgae are a promising alternative feedstock for producing biofuels (e.g., bioethanol and biodiesel) and bio-products (e.g., omega-3 and chlorophyll). However, the high cost of developing products from microalgae remains an obstacle to the full use of microalgae. Major hindrances to the commercial viability of algae are the operational and maintenance costs associated with large-scale cultivation. Most microalga cultivation operations rely on improvised photobioreactor designs, of which open-pond systems are frequently considered for large-scale operations. A cost-effective cultivation method is needed to improve the sustainability and economics of microalga cultivation, whilst minimising space and culture contamination and maintaining the integrity of desired species. Several photobioreactor designs are reviewed for the effective cultivation of microalgae, and the advantages and limitations of these photobioreactors are highlighted. Process challenges to scaling up the design of photobioreactors for commercial operations are also discussed

Preliminary Investigation of Myo-Inositol Phosphates Produced by ASUIA279 Phytase on MCF-7 Cancer Cells

Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice brans. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 µg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 ?g/ml. The inhibition of MCF-7 was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration.. KEYWORDS: myo-inositol phosphates, phytase, MCF-7,  cancer ABSTRAK: Fitat atau myo-inositol hexakisphosphate (IP6) dikenali umum teragih di dalam tumbuhan seperti dedak padi. Penghasilan perantaraan fosfat myo-inositol mendapat perhatian memandangkan ia berpotensi tinggi dalam kesihatan. Dalam kajian ini, kesitotoksikan sebahagian daripada fosfat myo-inositol separa tulen, IP1 komersil dan IP6 komersil dikaji terhadap produk yang berupa sel kekal (cell lines) kanser payu dara MCF-7. Tumbesaran sel MCF-7 direncatkan dalam pekatan minima fosfat myo-inositol (<1000 μg/ml). Tetapi, tidak ada perencatan dilihat terhadap sel kekal MCF-7 oleh sebahagian fosfat myo-inositol separa tulen daripada dedak padi pada kepekatan <1000 mg/ml. Perencatan MCF-7 hanya dilihat pada kepekatan lebih daripada 30 mg/ml dengan lebih daripada 40% sel terencat. Ini menunjukkan bahawa fosfat myo-inositol daripada dedak padi separa tulen terdegradasi oleh fitat ASUIA279 terhadap sel kanser MCF-7 dimana ia menunjukkan keputusan positif terhadap perencatan tumbesaran sel kanser pada kepekatan tinggi

Comparison Of Western Motivation Theories With Islamic Method

This article presents the excellence methodology of al-Targhib and al-Tarhib, according to the Qur'an against the Western motivation theory. The privileges mentioned in the Quran and al-Hadith, as well as practiced by the Companions in delivering the message of God, led by the Messenger's. This effort is the medium to those involved in missionary Islamiyya