Evaluation of the association between company performance and Iran’s stock market liquidity

This research studies the companies’ effectiveness and performance relationship with stock market liquidity in Tehran Stock Exchange during 2010-2015. Simultaneously, in the study, the three indicators: return on assets, return on investment and Tobin's Q ratio were applied as a measure of the performance and bid-ask spread as a measure of liquidity, bid-ask spread to the stock market. This research has a practical purpose and descriptive correlation in research nature and also post-event research. The under study population comprises all companies accepted in Tehran Stock Exchange during the intended period, 198 companies selected with systematic elimination sampling to be studied and analyzed. The results show a positive and significant association between companies’ performance and Stock market liquidity

Evaluation of anti-oxidant and antimelanogenic effects of the essential oil and extracts of Rosa × damascena in B16F10 murine melanoma cell line

Objective(s): Rosa × damascena Herrm. belonging to the Rosaceae family has demonstrated anti-inflammatory and anti-oxidant effects previously. Excessive production of free radicals and activation of tyrosinase enzyme caused by UV induces excessive concentration of melanin pigment and skin spots in the long term. Therefore, finding natural sources with anti-oxidant and antityrosinase effects helps to regulate the melanogenesis process.  In the current research, we investigated the antimelanogenic, anti-oxidant, and anti-tyrosinase effects of its essential oil, methanol extract (MeOH), and different fractions including n-hexane, dichloromethane (CH2Cl2), n-butanol (BuOH), ethyl acetate (EtOAc), and H2O of R. × damascena in B16F10 cell line.Materials and Methods: For this purpose, impacts of extracts and essential oil of R. × damascena were investigated on cell viability, cellular tyrosinase, melanin content, mushroom tyrosinase, reactive oxygen species (ROS) production, as well as the amount of tyrosinase protein in the B16F10 murine melanoma cell line.Results: Essential oil, MeOH, and different fractions of R. × damascena were not cytotoxic on B16F10 cells. However, they had significant reducing effects on mushroom tyrosinase activity, melanin content, and ROS production. Also, there is a significant decrease in tyrosinase protein levels at 200 µg/ml but not at other concentrations. Conclusion: Therefore, the essential oil, MeOH, and different fractions of R. × damascena had promising antimelanogenic activity via repression of mushroom tyrosinase activity and ROS production

Erratum: The genomic architecture of NLRP7 is Alu rich and predisposes to disease-associated large deletions

NLRP7 is a major gene responsible for recurrent hydatidiform moles. Here, we report 11 novel NLRP7 protein truncating variants, of which five deletions of more than 1-kb. We analyzed the transcriptional consequences of four variants. We demonstrate that one large homozygous deletion removes NLRP7 transcription start site and results in the complete absence of its transcripts in a patient in good health besides her reproductive problem. This observation strengthens existing data on the requirement of NLRP7 only for female reproduction. We show that two other variants affecting the splice acceptor of exon 6 lead to its in-frame skipping while another variant affecting the splice donor site of exon 9 leads to an in-frame insertion of 54 amino acids. Our characterization of the deletion breakpoints demonstrated that most of the breakpoints occurred within Alu repeats and the deletions were most likely mediated by microhomology events. Our data define a hotspot of Alu instability and deletions in intron 5 with six different breakpoints and rearrangements. Analysis of NLRP7 genomic sequences for repetitive elements demonstrated that Alu repeats represent 48% of its intronic sequences and these repeats seem to have been inserted into the common NLRP2/7 primate ancestor before its duplication into two genes

Yunis-Varón Syndrome: The First Report of Two Iranian Cases

The Yunis-Varón syndrome represents a rare autosomal recessive syndrome of easy recognition characterized by defective growth of the cranial bone along with complete or partial absence of the clavicles (cleidocranial dysplasia), absence of thumbs and halluces, distal aphalangia, ectodermal anomalies, growth retardation and poor outcome. The molecular genetic basis is unknown. Here, we report an 8 months old girl with Yunis-Varón syndrome, born to a consanguineously married, with normal parents. She had micrognathia, wide fontanels, prominent eyes, poor sucking, congenital heart diseases, asymmetric face, ambiguous genitalia, reduction anomaly in right hand including thumb, and hypoplastic distal phalanges of 3th fingers, and hypo plastic clavicles. She has glaucoma and lenses opacity. There is another similar case in her family. Karyotype is normal. She is the first Iranian known case of Yunis-Varón syndrome

Fraccaro Syndrome: Report of Two Iranian Cases: An Infant and an Adult in A Family

49,XXXXY is rare chromosomal pattern and these patients have mental retardation, small penis, cryptorchidism and skeletal anomalies. We reported a 10 month-old boy who has hypotonia, microcephaly, hypertelorism, depressed nasal bridge, epicanthic folds and bilateral multiple ear tags, high arched palate, down set ears, micrognathia and congenital heart disease such as patent ductus arteriosus (PDA), Atrial septal defect (ASD), mild pulmonary stenosis. Among the skeletal anomalies, he has kyphoscoliosis, clinodactyly of the fourth and fifth fingers of both hands, and bilateral club foot and unilateral dysplasia of the hip. Karyotype was found as 49,XXXXY[44]/48,XXXY[6] and this cytogenetic analysis was help to establish clinical diagnosis Fraccaro syndrome

A Comparative Study of Neuroprotective Effects of Human Adipose and Dental Pulp Derived Stem Cells on Hypoxic SH-SY5Y Cells Exposed to CoCl2

Background and purpose: Recent studies have demonstrated the promising effects of mesenchymal stem cells (MSCs) in some neurodegenerative diseases and proved their neuroprotective effects. But, the detailed pathways and the ability of MSCs from various sources has not been fully investigated. Materials and methods: Here, we isolated MSCs from two sources; adipose tissue and dental pulp, and compared the neuroprotective effects of adipose derived stem cells-conditioned media (ADSCs-CM) and dental pulp derived stem cells-conditioned media (DPSCs-CM) on SH-SY5Y cells exposed to Cobaltous chloride(CoCl2) as a model of hypoxia-induced neural damage. SH-SY5Y cells exposed to CoCl2 were treated with ADSCs-CM and DPSCs-CM and the cell viability, apoptosis, and cellular damage were determined by AlamarBlue ®assay, propidium iodide (PI) test, and lactate dehydrogenase (LDH) assay, respectively. Results: According to AlamarBlue® results, both ADSCs-CM and DPSCs-CM showed protective effects on SH-SY5Y cells exposed to CoCl2 at 0.6 mM for 12 and 24 h. Furthermore, ADSCs-CM could protect SH-SY5Y cells against hypoxic condition more intensively at all CoCl2 concentrations and various incubation incubation periods (P<0.01 and P<0.001, respectively). However, there were no significant differences between ADSCs-CM and DPSCs-CM. Also, ADSCs-CM and DPSCs-CM could considerably reduce the LDH release and apoptotic cells when SH-SY5Y cells were exposed to 0.6 mM CoCl2 for 24 h. Conclusion: The study indicated that both ADSCs-CM and DPSCs-CM have neuroprotective effects on hypoxic SH-SY5Y cells through reduction of apoptotic cells and release of LDH

Effect of Cinnamon and its Biologically Active Compounds on the Components and Symptoms of Metabolic Syndrome

Background and purpose: Metabolic syndrome refers to a set of diseases including insulin resistance, high blood glucose levels, obesity, high blood pressure, and dyslipidemia. The cinnamon plant is a member of the Lauraceae family and is considered a universal medicinal plant. Traditional medicine studies reported the therapeutic effects of this plant in the reduction of blood glucose levels, blood pressure, obesity, and improving dyslipidemia. The present study aimed to review the effect of cinnamon and its active compounds on metabolic syndrome. Materials and methods: The search was carried out in Science Direct, Google Scholar, Pub Med, Scopus, and SID using the following keywords: cinnamon, cinnamaldehyde, obesity, high blood pressure, diabetes, and blood lipid profiles. Relevant articles published in May 2007 to September 2022 were selected. Results: Data obtained from different studies (clinical studies, in vivo) on the effects of cinnamon and its active ingredients showed the protective effects of this plant in metabolic syndrome in different ways. Conclusion: Cinnamon could decrease the rate of complications and mortality caused by metabolic syndrome