Hadipour, Zahra

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6L.JS s#b.rJ .,j.,..il.4.r gLoui g ,.ssrti p3Js ol<,n'.loisiJ;f.r fJJs J (r'iL,,Jj;lu ous*'iil.r6jLeg3lo it'J.os 15fJiS.r crtl 6bq: ol3r.cj+-, ctt? JJ.BI o.;1, ^a 6Jb ?^.? Lti.o Ji.f d:*(J,dLA.r r:il sLo3.r JJr& a; pamellia Sinensis L ), t".",.JiJy 6,rLa lJaj: Lalal3 q$L-rf.-J-il'.i eLg iS.lli, J I r.rWs#l+J.p l,.if iso"."...:+oLr 6hq o;Lo-i \f12s[3.,,.,.t3Kerman University of Medical SciencesSchool of PharmacyFor the certificate of Pharm. D DegreeTitle:Mucoadhesive preparation containing ethanol extract of green tea(Camellia Sinensis L) for treatment of RASBy:Zahra HadipourSupervisors:Dr" Payam KhazaeliDr. Mitra MehrabaniSummer 2017 Thesis NO:c:-)b ap,.>-ag)/r;cg;!-q ;: .(*i JL(- ,*UJ* ,, Gf, GL^ J-r''.* jl (RAS) +.-11 ;l 3la: '.'tll :uJi,,*atS ,517i V-e s ui"y, ,>tt' q +;l rdL;) 3 .:;[i :3.--e 6!G oL;r 1t+l ,ltit :;19" ;l.t_#.1 ;:st' 6;L-. o;y> JJ, .J;-Is i s .-r":S-. s :t>r-*'*;"* tLu< "!f sLn J-r -,i :-" gh ,'u.:---^ iL;.: ;r Srs, ,si:t -!,1r" ;-j;l: lGf(-u; : :*Jl -u., ,jl-l.*51 ,-i :ly )\ ,p j?- Gq >j* C * (Camellia Sinensis L ).rr1.! L- .it"Fq L:" 5 gtn.: .-'L@l JjS slt. 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"i"+ ,l 31 ;!"J -&"r* :rt"ara-.r;L ., *-*z !ti" a,-L 1l o;Lo-c a;L>r;i'<; ;4 ;rs-s \ o*\-, J -t.: qii o[5 o.r'- Ja] g;tal "# :t J;t- "rto-" )rzl ,silt*5 'u; qd .r*.r-\ .Ct ;*lr! -r ;!l J ff Lj;' ef j"*o)f )r- l. .-L-r;')*,_P gS :.-S f,-*" yt'l ;l 3t.o: :-*i !t*" ;r^- .>y-g o:G:-l r."; a,-L'li;;1.a-l o-L"i .*) r J* .r-)q .,-li;: ,",); J -=1;- Jtr ---q -tE* ,a* *:W;l y +!Lil qL; ot l-, olS 6o;Las .(;.>- ;;y -t, .5+Lr," ;r.J".; 4x{j /.\0 i-Ei; L4*i *il:i" ugG .i:-r .: t:y 5l;,-l ;l .jA:;-.g1oJ^a;r ! o*X ',;*-) -f t \' :6311 3 LlclL.,tt.4 ;1 ;: 5 -\,,-u u*)t c*31 c--* J G;l-is--,1r:=" .--,1;! )-ff) ,gyl) ,cl-i -E t\ s,,J***< rtlr^") a,-yl,i Jrs.:,b-t")i P )l Goy*-\:"; ;1 .Ji:y llL" J*-!i,"i 0.-r,u a:!7-4 JS";Y j[. il-l ;: aS a;sf :\] ,r-:,t,-,-r" (Jr:*.,*;-: 6uL.y,.J*f :\; tl_;;L-l i,I* L-i S;; ,tsi ,r;r.->j J o-L; .--,E;.li L^J-r";.rrr,.1-L*6a,-! ;: ,-rl:,cs" \: -r* S4 a)Las' $) S u&;i*j r,,-l ;1 t'r"i ;--i' 6-U t "-, Ll;s^. l-f-p;br.SL^e=;,-o c-ii jLl:;: ry;6 dl,1 ,-*[;,51L:1;1 L -*--= -bl;"h" 6q o;las ,-."..2 Lt -;.c.il :(.'4*15 cJt 15 J l'. .jbIT.r;K:t .->L-AbstractIntroduction: Recurrent aphthous stomatitis (RAS) is common worldwide illness. Inmany cases there is absolutely effective treatment and therapy, often merely to ease thepain and irritation symptoms and reduce the duration of illness occurs.Medicinal herbs are effective therapeutic agents, green tea (Camellia Sinensis L)prepration from sheets of Camellia Sinensis.green tea is rich of antioxidant, antiinflannation and anticancer agent. use of this herb to control local inflammation of themouth which are bacterial or fungal source is very useful and effective.Mucoadhesive drug delivery systems because of their ability to extend the permanencedrug in locality, release the drug slowly and consequently better effectiveness are highlyregarded in recent decades" These systems due to the considerable surface area andblood flow, increase bioavailability and drug absorption.According to the beneficial effects of green tea, adding it to the base of themucoadhesive cause covering effects and eventually can effect as double in treatment ofaphthous. The aim of this study was to formulate mucoadhesive and evaluation itsphysicochemical properties such as adhesion strength, distributive, coverage and releaseof extract from the mucoadhesive base.Methods: methanol extract of dried petals of plant has been prepared. A mixture ofpolyethylene and liquid paraffin provide plastibase which used as base of formulation.Mucoadhesive oral paste was prepared from combination of sodium carboxymethylcellulose, pectin and gelatin with plastibase. The methanolic plant extracts added to themix and finally green tea mucoadhesive paste with a concentration of 15oZ wasobtained.Basic formulation with different percentages of the above Conclusion and Results: 10conponents prepared in different ways in different ways. And were investigated visualproperties, discrete particles, uniformity and thumb tests. that the five formulations werefavorable. These formulations were examined About secondary control test (adhesion,coverage and distributive), among which 3 formulation were accepted.Selected the most appropriate formula and drug release were investigated with Franzdiffusion cells.according to the results of this research was determined can be formulated Extract ofgreen tea at the base of the mucoadhesive with suitable release for use in the treatmentof aphthous ulcers and mouth sores.Key words: aphthous, Mucoadhesive paste, Extract of green tea

تهیه خمیر مخاط چسب حاوی عصاره اتانولی چای سبز ( Camellia sinensis L ) به منظور درمان آفت دهانی

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