Modern Research Techniques of Apoptotic Cell Death (Review)

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Features of Morphological Changes in Experimental CT-26 Tumors Growth

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Pathogenetic Aspects of Treatment of a Chronic Cystitis

The analysis of mucosa's state of the bladder in treating the exacerbation chronicle cystitis in 67 women was made. The analysis was made with the use of the method of optical coherent tomography (ОСТ). Dynamic ОСТ was performed in 23 patients after antibacterial treat (after 2 weeks) and in the period of remission. It was 59 ОСТ examinations. After antibacterial treatment the pathologically unchanged mucosa was found in the form of thickening in interu-retericfold in Lieutands triangle, in the neck of urinary bladder. Sub mucosal layer was also think, the structure of fibers was destroyed. Both leucocytic and lymphocytic infiltration in the wall of the bladder was observed. The tissue which reflected the light signal was found in muscle structure in the period of remission. This correspond to fibrosis in the wall of the bladder. In the long process the atrophy of mucosa was found. Thus, pathogenetic therapy should proceed after decrease in expressiveness of clinical displays of diseas

Skin Tissue-Engineering Constructs and Stem Cells Application for the Skin Equivalents Creation (Review)

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3-D optical coherence tomography of the laryngeal mucosa

Laryngeal carcinoma is one of the commonest primary head and neck malignancy and the need for early identification is very important for successful treatment. Outpatient fibreoptic examination of the larynx is unreliable in differentiating benign, pre-malignant and malignant lesions, and therefore surgeons have to rely on biopsies for a definitive diagnosis. This is an invasive procedure requiring general anaesthesia and may have a detrimental effect on the patient's voice. Conventional imaging modalities (ultrasound, computed tomography and magnetic resonance imaging) have a limited resolution and hence cannot give sufficient information on the extent or nature of laryngeal lesions. The aim of our study is to investigate the feasibility of optical coherence tomography (OCT) in imaging the normal larynx, to lay the foundations for an investigation of its ability to differentiate between benign and malignant disease. Ten tissue specimens from normal larynges were imaged with an 850 nm OCT system that was capable of providing both B-scan (longitudinal or cross-section) images as well as C-scan (en-face or images at constant depth). The en-face OCT mode allowed us to reconstruct 3-D OCT images of the tissue examined. Imaged specimens were processed with standard histopathological techniques and sectioned in the plane of the B-scan OCT images. Haematoxylin-eosin stained specimens were compared with the OCT images thus collected. Preliminary results showed good correlation between OCT images and histology sections in normal tissue