Evaluation of endometrial polyps in terms of mast cells, estrogen and progesterone receptors, MMP-2, MMP-9, and COX-2 markers and distribution of endometrial polyps in menopausal/premenopausal breast cancer patients

Objective: In this study, it was aimed to determine the expression of ER, PR, mast cell, MMP-2, MMP-9, and COX-2 in endometrial polyps, to evaluate whether they have a role in etiopathogenesis and to reveal whether the information obtained in this way can be used in treatment. Additionally, it aimed to show the distribution of these markers in endometrial polyps in menopausal and premenopausal breast cancer patients. Materials and methods: In this study, 51 patients who were reported as having "endometrial polyp" as a result of pathological examination of endometrial curettage or hysteroscopic polyp extirpation materials in Gynecology and Obstetrics Service of Gülhane Military Medical Academy Haydarpaşa Training Hospital were evaluated retrospectively. Results: While the rate of patients with moderate immunohistochemical staining of MMP-2 in postmenopausal patients (47.1%) was found to be significantly higher than the premenopausal group (11.8%), the rate of patients with weak immunohistochemical staining (47.1%) in premenopausal patients was compared to the postmenopausal group (14.7%) was found to be statistically significantly higher. The prevalence of immunohistochemical staining of MMP-9 in the group receiving HRT among postmenopausal patients was found to be statistically significantly higher than in those who did not receive HRT (p=0.012). The immunohistochemical staining intensity of MMP-9 in the group receiving HRT among postmenopausal patients was also found to be statistically significantly higher than those who did not receive HRT (p=0.012). Conclusions: As a result, MMP-2, MMP-9, and mast cells may contribute to the endometrial polyp formation steps in postmenopausal patients. The possible contribution of MMP-2, MMP-9, and mast cells to the etiopathogenesis may resolve the contradictions in the formation mechanism of postmenopausal polyps. If this information is proven as a result of more comprehensive studies to be done later, it may be possible to prevent endometrial polyps and to create non-surgical treatment options, especially in the general postmenopausal patient group and in patients receiving HRT

The protective effects of different treatments on rat salivary glands after radiotherapy

WOS: 000387700400056PubMed ID: 27324888This study was aimed to evaluate the efficacy of treatment modalities for minimizing salivary gland damage caused by radiotherapy. Forty rats were divided into five groups. Group 1 had no irradiation or any treatment. Group 2 underwent only 15 Gy single dose radiotherapy. N-acetylcysteine, dexamethasone, hyperbaric oxygen treatment were given, respectively to the group 3, 4 and 5 for 5 days. 15 Gy single dose radiotherapy was applied to the group 3, 4 and 5 on the second day. Pyknosis, lysis, and vacuolization were examined in ductal cells and pyknosis, lysis, vacuolization, inflammation and collective duct damage in acinar cells. Dexamethasone and hyperbaric oxygen did not prove to have a positive effect on acinar and ductal cell. N-acetylcysteine-applied group had statistically significantly lower amount of damage. We determined that the decrease of ductal and acinar cell damage in parotid glands of N-acetylcysteine-applied rats was more distinct and statistically

Nadir bir sinüs enfeksiyonu etkeni olarak citrobacter koseri: bir olgu raporu

Maksiller posterior bölgede yapılan diş çekimleri sırasında maksiller sinüs ile ilişkili çok sayıda komplikasyon ile karşılaşılmaktadır. Diş kökenli maksiller sinüzitlerin %10’unu oluşturan sinüse kök kaçırılması dental kaynaklı nedenlerden birisidir. Literatürde dental kaynaklı sinüs enfeksiyonu oluşturabilen birçok bakteri türünden bahsedilmesine rağmen, enterik bir bakteri olan Citrobacter koseri (C. koseri) nadir görülen bir sinüs enfeksiyonu etkenidir. 34 yaşındaki, bayan hasta, kliniğimize üst çene sağ taraf büyükazı dişler bölgesinde ağrı şikayeti ile başvurdu. Yapılan radyografik inceleme sonucunda hastanın maksiller sinüsünde rezidüel kök tespit edildi. Mevcut residüel kök Caldwel Luc cerrahisi ile çıkarıldı. Hastanın şikayetleri ortadan kalktı. Yeşil renkli olan diş kökü mikrobiyoloji laboratuvarında anaerobik ve aerobik olarak kültüre edildi. 37 °C’taki 24 saatlik aerobik inkübasyonu takiben gram negatif basil morfolojisine sahip saf koloniler saptandı. Koloniler konvansiyonel yöntemlerin yanısıra VITEK2 Compact otomatik identifikasyon sistemi ile de C. koseri olarak tanımlandı

Przerzuty raka sutka do skóry – różne obrazy kliniczne

Cutaneous metastases usually appear as nonspecific groups of discrete, firm, painless nodules that emerge rapidly without any explanation. Some skin metastases may mimic specific dermatological conditions such as cutaneous cysts, dermatofibroma, granuloma teleangiectodes, hemangioma, herpes zoster eruptions, rapidly infiltrating plaques, alopecic patches, erysipelas and cellulitis [1].Przerzuty nowotworów narządów wewnętrznych do skóry mają zazwyczaj postać niecharakterystycznych, twardych, niebolesnych guzków, które pojawiają się nagle, bez uchwytnej przyczyny. Niektóre przerzuty do skóry mogą imitować inne schorzenia dermatologiczne, np.: torbiele, włókniaki, ziarniniaki naczyniowe, naczyniaki, zmiany skórne w przebiegu półpaśca, łysienie z innych przyczyn, różę i stan zapalny tkanki podskórnej [1]

An unusual case of erythema annulare centrifugum involving face

Erythema annulare centrifugum (EAC) is a reactive figurate erythematous disease characterised by gyrate and annular plaques with erythema. The disease is generally known as involving the extremities and trunk, but sparing the face. We present a young male patient with recurring annular erythematous scaly lesions on his face, frequently in a year since four years, with no systemic involvement. Histologically, in addition to slight parakeratosis and spongiosis in the epidermis, there was superficial lymphocytic and histiocytic perivascular infiltration with the classic coat sleeve appearance of EAC in the dermis. Although uncommon, we suggest EAC should be considered in the differential diagnosis of relevant lesions on face

Unusual Huge Keratoacanthoma in Sites of in the Previous Split-Thickness Skin Grafted Area

Keratoacanthoma (KA) is a fairly common keratinizing, squamous neoplasm. The exact etiology of KA is unknown. However, ultraviolet radiation, trauma, chemical carcinogens, viral infections, immunosuppression, genetic factors, radiation and thermal burns have been accused of pathogenesis. In here, we represent an unusual huge KA arising from the previous reconstructed with split-thickness skin graft on the dorsal foot

Pulmonary alveolar proteinosis: Report of two cases

Pulmoner alveoler proteinozis, alveollerde ve distal hava yollarında lipoproteinöz madde birikimiyle karakterize nadir bir hastalıktır. En sık rastlanan semptomlar nefes darlığı ve kuru öksürüktür. Radyolojik olarak bilateral simetrik alveoler konsolidasyon veya buzlu cam görüntüsü saptanır. Tanı sıklıkla klinik ve radyolojik bulgular eşliğinde transbronşiyal biyopsi örneği veya bronkoalveolar lavaj (BAL) ile alınan intra alveoler materyalin periyodik asit-Schiff metodu ile pozitif boyanması ile konur. Pulmoner alveoler proteinosis için standart tedavi total akciğer lavajıdır. Çalışmamızda, biri BAL diğeri açık akciğer biyopsisi ile tanı alan iki pulmoner alveoler proteinozis olgusu literatür eşliğinde sunulmuştur.Pulmonary alveolar proteinosis is a rare disease characterised with lipoproteinous material deposition in alveoles and distal airways. The most common symptoms are dyspnea and dry cough. The radiographic finding is bilateral, symmetric alveolar consolidation or ground-glass opacity. The diagnosis is mostly made by positive staining of transbronchial biopsy or bronchoalveolar lavage (BAL) material with periodic- acid-Schiff method accompanied by clinical and radiological findings. The standard treatment for pulmonary alveolar proteinosis is total lung lavage. In our study, two cases of pulmonary alveolar proteinosis, one diagnosed by open lung biopsy and the other with BAL, were presented with the literature