Bayesian Inference of Pair-Copula Constriction for Multivariate Dependency Modeling of Iran’s Macroeconomic Variables

Bayesian inference of pair-copula constriction (PCC) is used for multivariate dependency modeling of Iran’s macroeconomics variables: oil revenue, economic growth, total consumption and investment. These constructions are based on bivariate t-copulas as building blocks and can model the nature of extreme events in bivariate margins individually. The model parameter was estimated based on Markov chain Monte Carlo (MCMC) methods. A MCMC algorithm reveals unconditional as well as conditional independence in Iran’s macroeconomic variables, which can simplify resulting PCC’s for these data

X-linked hyper-IgM syndrome associated with pulmonary manifestations: A very rare case of functional mutation in CD40L gene in Iran

Hyper IgM (HIGM) syndromes are a complex of primary immunodeficiency disorders. A 4-years-old boy with recurrent fever and chills, dyspnea, sort throat for a month was admitted to emergency department. In the current case, whole exome sequencing followed by Sanger sequencing were employed in order to screen probable functional mutations. Molecular analysis revealed a functional mutation across the CD40L gene (NM000074: exon5: c.T464C) resulted in amino acid change p.L155P attributed to X-linked hyper IgM syndrome. The findings of the current study signify the critical role of microbial infection as well as XHIGM screening, particularly in those children cases with respiratory symptoms. © 2018 Elsevier Masson SA

X-linked hyper-IgM syndrome associated with pulmonary manifestations: A very rare case of functional mutation in CD40L gene in Iran

Hyper IgM (HIGM) syndromes are a complex of primary immunodeficiency disorders. A 4-years-old boy with recurrent fever and chills, dyspnea, sort throat for a month was admitted to emergency department. In the current case, whole exome sequencing followed by Sanger sequencing were employed in order to screen probable functional mutations. Molecular analysis revealed a functional mutation across the CD40L gene (NM000074: exon5: c.T464C) resulted in amino acid change p.L155P attributed to X-linked hyper IgM syndrome. The findings of the current study signify the critical role of microbial infection as well as XHIGM screening, particularly in those children cases with respiratory symptoms. © 2018 Elsevier Masson SAS

Acute Effect of One Incremental Exhausting Cycling Session with Hand on the Response of T and NK Cells of Immune System in Student Athletes

Introduction: Various sorts of physical activites cause various changes in body immune system. The purpose of this study was to examine the acute effect of one incremental exhausting cycling session with hand on the response of T and NK cells of immune system of male physical education students. Methods: In this study, twenty male subjects with mean age of 22.4±1.8(SD) years, mean Vo2 max 41.7±7.1(SD) ml/kg/min and mean BMI 23±1.87(SD) kg/m2 were divided randomly into control(n=10) and experimental group(n=10). The subjects of experimental group performed Sawaka. Protocol, whereas the subjects of control group did not participate in any exercise activity. Blood samples were taken from brachial vein of control and experimental subjects during pre-test, post-test and two hours after the end of exercise. For analysis of statistical data, t-independent and t-correlated tests ( =0.05 significant) were used. Results: Immediately after training, the percentage of CD8 (T) and CD16.56 (NK) cells increased significantly (P≤0.005, P≤0.001). On the other hand, the ratio of CD4/CD8 cells and the percentage of CD4 (T) cells showed significant decrease (P≤0.002, P≤0.001). In addition, the percentage of CD56 and CD16 (NK) cells did not change significantly. It is worth mentioning that these changes after two hours returned to the normal state at the end of the sport test (P≤0.251, P≤0.229). Conclusion: One acute training session with hand causes both increase and decrease in T and NK cells of immune system function. But, these changes are temporary and return back to normal levels within a few hours

Association of Benign Joint Hypermobility Syndrome with Mitral Valve Prolapse in Iranian Children Benign Joint Hypermobility with MVP 116

Abstract Aim and purpose: The aim of this study was to determine the association of benign joint hypermobility syndrome (BJHS) with mitral valve prolapse. Subjects and methods: This is a case-control study. Sixtythree children with benign joint hypermobility syndrome were included in case group and 63 without any rheumatologic disease were placed in control group. We used Carter-Wilkinson and Beighton criteria for diagnosing of benign joint hypermobility syndrome. Mitral valve prolapse was evaluated by echocardiography in both groups. The mitral leaflet displacement >2 mm considered as cut off for diagnosis of mitral valve prolapse. Cardiologist did not have any information about patients group during echocardiography. Data was analysed using SPSS ver. 13.0. Chi-square used for comparison. Results: In this study, 32 girls and 31 boys were included. Mean of age in case group was 7.1±2.67 and for control was 6.9±3.25 years. Mitral valve prolapse was discovered in 54% of cases and 12.7% of control groups (P=0.001). Mitral valve prolapse was significantly higher among cases with BJHS aged >7 (58.8%) year compared to 3-7 (41.2%) year of age (P=0.027). Heart murmur and palpitation was more common among children with benign joint hypermobility syndrome with mitral valve prolapse compared to children without mitral valve prolapse (P<0.05). Conclusion: The incidence of mitral valve prolapse among children with benign joint hypermobility was significantly higher than control group