Strategic latency and world order

The article of record as published may be found at http://dx.doi.org/10.1016/j.orbis.2010.10.006This article examines "strategic latency", a condition in which technologies that could provide military (or economic) advantage remain untapped. As difficult as it is to explain why certain ideas and technologies flourish and find rapid acceptance, it is equally hard to understand why some good ideas languish, only to be rediscovered and exploited under other circumstances. Why is latent capacity so often dormant? What are the indicators that latent capacity is on the verge of being weaponized

Embracing The Path: A Story Of Leadership, Transformation, And Adventure

This capstone retells a journey of transformation through self-realization and personal development, made possible through the collective learning experiences and inspirations provided during my course of study in the Organizational Dynamics program at the University of Pennsylvania. The concepts are purposefully woven together in a story format to reinforce the importance of balance across multiple versions of self, highlighting personal development experiences, adventures, and the resultant growth as a person and leader. The paper focuses on topics of work-life balance and self-awareness in exploration of their usefulness in leader development, orchestrating change management initiatives, and improving overall effectiveness in organizations. This paper intentionally unfolds as an introspective narrative sharing reflections and applications of leadership techniques as a tool to foster a deeper connection between organizations and the people that thrive within them. This paper also seeks to serve as inspiration for others contemplating a journey of personal transformation

Of Flyers and Free Speech: How Student Activism Defined the Contours of One University’s 21st-Century Hate and Bias Policy

Since 1999, The University of Texas at Austin (UT Austin) operated under a Student Policy on Race Relations when handling hate and bias incidents. In February 2017, an anti-Muslim flyer was posted near campus, prompting UT administration to hold a town hall for UT student activ-ists to vocalize their concerns. Through Kezar’s (2010) description of modern student protests and Barnhardt’s (2014) framework for modern student protests, this study analyzes the marginal-ized UT Austin student voices of that town hall meeting, demonstrating how modern student activism influenced presidential rhetoric and a new Hate and Bias Incidents Policy, the first in nearly two decades at UT Austin.Educatio

DOE Security: Protecting Nuclear Material and Information

Congress is focusing on problems with security at the Department of Energy’s (DOE) national security facilities, especially the nuclear weapon laboratories. Problems include espionage from within the labs and protection of nuclear material and facilities from outside attack. This report describes the main components of DOE’s security system and reviews current efforts to address shortcomings

Motif-based communities in complex networks

Community definitions usually focus on edges, inside and between the communities. However, the high density of edges within a community determines correlations between nodes going beyond nearest-neighbours, and which are indicated by the presence of motifs. We show how motifs can be used to define general classes of nodes, including communities, by extending the mathematical expression of Newman-Girvan modularity. We construct then a general framework and apply it to some synthetic and real networks

Implementation and preliminary clinical outcomes of a pharmacist-managed venous thromboembolism clinic for patients treated with rivaroxaban post emergency department discharge

Objective To describe the implementation, work flow, and differences in outcomes between a pharmacist-managed clinic for the outpatient treatment of venous thromboembolism (VTE) using rivaroxaban versus care by a primary care provider. Interventions Patients in the studied health system that are diagnosed with low-risk VTE in the emergency department are often discharged without hospital admission. These patients are treated with rivaroxban and follow up either in a pharmacist-managed VTE clinic or with their primary care provider. Pharmacists in the VTE clinic work independently under a collaborative practice agreement. An evaluation of thirty-four patients, seventeen in each treatment arm, was conducted to compare the differences in treatment-related outcomes of rivaroxaban when managed by a pharmacist versus a primary care provider. Results The primary endpoint was a six month composite of anticoagulation treatment-related complications that included a diagnosis of major bleeding, recurrent thromboembolism, or fatality due to either major bleeding or recurrent thromboembolism. Secondary endpoints included number of hospitalizations, adverse events, and medication adherence. There was no difference in the primary endpoint between groups with one occurrence of the composite endpoint in each treatment arm (p=1.000), both of which were recurrent thromboembolic events. Medication adherence assessment was formally performed in 8 patients in the pharmacist group versus 0 patients in the control group. No differences were seen amongst other secondary endpoints. Conclusions The pharmacist-managed clinic is a novel expansion of clinical pharmacy services that treats patients with low-risk VTEs with rivaroxaban in the outpatient setting. The evaluation of outcomes provides support that pharmacist-managed care utilizing standardized protocols under a collaborative practice agreement may be as safe as care by a primary care provider

Detecting network communities by propagating labels under constraints

We investigate the recently proposed label-propagation algorithm (LPA) for identifying network communities. We reformulate the LPA as an equivalent optimization problem, giving an objective function whose maxima correspond to community solutions. By considering properties of the objective function, we identify conceptual and practical drawbacks of the label propagation approach, most importantly the disparity between increasing the value of the objective function and improving the quality of communities found. To address the drawbacks, we modify the objective function in the optimization problem, producing a variety of algorithms that propagate labels subject to constraints; of particular interest is a variant that maximizes the modularity measure of community quality. Performance properties and implementation details of the proposed algorithms are discussed. Bipartite as well as unipartite networks are considered.Comment: 16 pages, 3 figures, 6 tables; significant expansion of discussion of result

Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding

Background: We sought to determine if ripple oscillations (80-120Hz), detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate with an enhancement or disruption of verbal episodic memory encoding. Methods: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch, and included the seizure onset zone (SOZ) as a covariate in the LRMs. Results: We detected events during 58,312 word presentation trials from 7,630 unique electrode sites. The probability of ripple on spike (RonS) events was increased in the seizure onset zone (SOZ, p<0.04). In the left temporal neocortex RonS events during word presentation corresponded with a decrease in the odds ratio (OR) of successful recall, however this effect only met significance in the SOZ (OR of word recall 0.71, 95% CI: 0.59-0.85, n=158 events, adaptive Hochberg p<0.01). Ripple on oscillation events (RonO) that occurred in the left temporal neocortex non-SOZ also correlated with decreased odds of successful recall (OR 0.52, 95% CI: 0.34-0.80, n=140, adaptive Hochberg , p<0.01). Spikes and RonS that occurred during word presentation in the left middle temporal gyrus during word presentation correlated with the most significant decrease in the odds of successful recall, irrespective of the location of the SOZ (adaptive Hochberg, p<0.01). Conclusion: Ripples and spikes generated in left temporal neocortex are associated with impaired verbal episodic memory encoding

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.

Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we developed a co-culture system to systematically assay the ability of 23 stromal cell types to influence the innate resistance of 45 cancer cell lines to 35 anticancer drugs. We found that stroma-mediated resistance is common, particularly to targeted agents. We characterized further the stroma-mediated resistance of BRAF-mutant melanoma to RAF inhibitors because most patients with this type of cancer show some degree of innate resistance. Proteomic analysis showed that stromal cell secretion of hepatocyte growth factor (HGF) resulted in activation of the HGF receptor MET, reactivation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI(3)K)-AKT signalling pathways, and immediate resistance to RAF inhibition. Immunohistochemistry experiments confirmed stromal cell expression of HGF in patients with BRAF-mutant melanoma and showed a significant correlation between HGF expression by stromal cells and innate resistance to RAF inhibitor treatment. Dual inhibition of RAF and either HGF or MET resulted in reversal of drug resistance, suggesting RAF plus HGF or MET inhibitory combination therapy as a potential therapeutic strategy for BRAF-mutant melanoma. A similar resistance mechanism was uncovered in a subset of BRAF-mutant colorectal and glioblastoma cell lines. More generally, this study indicates that the systematic dissection of interactions between tumours and their micro-environment can uncover important mechanisms underlying drug resistance