Variation in some Haematological Parameters in Newborns at Different Locations in Delta State, Nigeria

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Abnormal haemoglobin variants, ABO and Rh blood groups among student of African descent in Port Harcourt, Nigeria

Background: Abnormal haemoglobin variants ( HbSS,AS,AC,SC,etc) have been known to be common among blacks. Patients with sickle cell disease are often faced with the risk of alloimmunization from allogeneic blood transfusion Objectives: The study was designed to sample students population of African descents for the purpose of updating information on the prevalence of abnormal haemoglobin variants, ABO, and Rh blood groups and compare the results with previously published data. Methods: Standard electrophoretic and haemagglutination techniques were employed in testing the blood samples. Results: Of the 620 students screened, 80.32% were HbAA and 19.68% HbAS. 22.9% were of blood group A, 17.10% group B, 4.84% group AB and 55.16% group O. 96.77% were Rh.D positive while 3.23% were Rh D negative. Sickle cell gene in homozygous state (HbSS) and other abnormal haemoglobin variants were not encountered in this students population,. Analysis of the students population revealed that 454(73.23%) were females while 166(26.77%) were males. Participants of the age group 26-30 years (35.7%) constituted the majority and in this age group, all blood groups were represented. Conclusion: There is a gradual decline in the prevalence of abnormal haemoglobin variants in our black population. The frequencies of ABO and Rh blood groups however appeared to be stable and consistent with previous published data. Keywords: haemoglobin genotypes, blood groups, ABO, Rh, Nigeria African Health Sciences Vol. 6(3) 2006: 177-18

Abnormal haemoglobin variants, ABO and Rh blood groups among student of African descent in Port Harcourt, Nigeria

BACKGROUND: Abnormal haemoglobin variants ( HbSS,AS,AC,SC,etc) have been known to be common among blacks. Patients with sickle cell disease are often faced with the risk of alloimmunization from allogeneic blood transfusion OBJECTIVES: The study was designed to sample students population of African descents for the purpose of updating information on the prevalence of abnormal haemoglobin variants, ABO, and Rh blood groups and compare the results with previously published data METHODS: Standard electrophoretic and haemagglutination techniques were employed in testing the blood samples. RESULTS: Of the 620 students screened, 80.32% were HbAA and 19.68% HbAS. 22.9% were of blood group A, 17.10% group B, 4.84% group AB and 55.16% group O. 96.77% were Rh.D positive while 3.23% were Rh D negative. Sickle cell gene in homozygous state (HbSS) and other abnormal haemoglobin variants were not encountered in this students population,. Analysis of the students population revealed that 454(73.23%) were females while 166(26.77%) were males. Participants of the age group 26–30 years (35.7%) constituted the majority and in this age group, all blood groups were represented. CONCLUSION: There is a gradual decline in the prevalence of abnormal haemoglobin variants in our black population. The frequencies of ABO and Rh blood groups however appeared to be stable and consistent with previous published data

An Assessment of the Clinical Utility of Routine Antenatal Screening of Pregnant Women at First Clinic Attendance for Haemoglobin Genotypes, Haematocrit, ABO and Rh Blood Groups in Port Harcourt, Nigeria

This prospective study was designed to provide the frequencies of the haemoglobin genotypes, ABO and Rh blood groups and their effects on the haematocrit values among pregnant women in Port Harcourt. One hundred and eighty (180) pregnant women at their first clinic attendance and in their first pregnancy (parity - 0) participated in this study. The overall frequencies obtained for ABO and Rh blood groups were: 26.67% for group A, 18.33% for B, 2.22% for AB and 52.78% for O. Rh D positive was 95.56% while Rh D negative was 4.44%. The frequencies of haemoglobin genotypes were 70.00% for HbAA, 29.44% for HbAS and 0.56% for HbSS. HbAC and SC did not occur in this study population. The mean haematocrit value was 34.64%. This was found to be independent of the ABO and Rh blood groups (P>0.05). On the other hand, haemoglobin genotypes were found to exert significant effects on the haematocrit values (F = 8.01, P = 0.0005). No significant relationship was found to exist between age and the haematocrit values. (F = 0.91, P > 0.05). Since pregnancy in sickle cell disease is associated with morbidity, proper antenatal monitoring and counselling will be necessary to prevent fatal outcomes. (Afr J Reprod Health 2005 2005; 9[3]:112-117

The effect of Plasmodium falciparum malaria on platelet counts in patients attending the University of Calabar Teaching Hospital, Nigeria

This prospective cross-sectional study was aimed at assessing the effect of Plasmodium falciparum malaria on platelet count among various categories of hospital patients in the University of Calabar Teaching Hospital, Calabar, Nigeria. A total of six hundred and ten (610) patients participated in the study and three hundred and sixty (360) non-malaria infected patients were used as controls. The prevalence rate of Plasmodium falciparum malaria in this study was 40.98%. The mean platelet count of 113 ± 57 x 109/L observed in the malaria infected patients was found to be significantly lower than the mean count of 168 ± 48 x 109/L in the non-infected subjects (controls) (t = 4.867,

Sero-epidemiology of transfusion-transmissible infectious diseases among blood donors in Osogbo, south-west Nigeria

Objetivo. Determinar la seroprevalencia de VIH en los donantes del banco de sangre del Hospital San Jerónimo de Montería entre los años 2017 al 2019. Materiales y métodos. Se realizo un estudio descriptivo de corte transversal en donantes en el Banco Nacional De Sangre del Hospital San Jerónimo de Montería durante los años 2017-2019, 21.192 donantes fueron seleccionados bajo los criterios de la regulación vigente (resolución 901 de 1996). El análisis de datos se realizó en tres procesos básicos: codificación, tabulación y construcción de tablas y gráficos. La técnica utilizada para la verificación estadística de los resultados fue mediante analizador estadístico. Resultados. La prevalencia de la infección por VIH resultó en decrecimiento en comparación con cada uno de los tres años consecutivos abarcados en el estudio. Durante el periodo 2017-2019, 26 personas resultaron reactivas a la prueba de tamizaje (reactividad 0,12%) de las cuales 19 fueron confirmadas VIH positivos (prevalencia 0,31%). El hallar una mayor prevalencia en mujeres, donantes de reposición y personas de entre 31 a 40 años de edad, residente en el municipio de Montería constituye un hallazgo de interés para la orientación de investigaciones analíticas posteriores que confirmen las relaciones exploratorias detectadas en esta población. Conclusión. La prevalencia de infección por VIH y reactividad encontradas son similares a las reportadas en estudios nacionales e internacionales. Es importante mantener los criterios de tamización en los bancos de sangre ya que permite identificar donantes seropositivos asintomáticos.INTRODUCCIÓN ............................................................................................................91.MARCO TEÓRICO......................................................................................................121.1.Síndrome de la inmunodeficiencia humana adquirida y virus de la inmunodeficiencia humana..............................121.2. Transmisión del VIH...................................................................................................121.3. Marco normativo................................................................................................161.4. Selección del donante....................................................................................181.5. Marcadores de VIH en banco de sangre.......................................................192.OBJETIVOS.....................................................................................................................232.1.Objetivo general....................................................................................................232.2.Objetivos especificos...............................................................................................233.METODOLOGIA...........................................................................................................233.1.Área de estudio.......................................................................................................233.2.Tipo de estudio.....................................................................................................243.3.Población de estudio..........................................................................................243.4.Variables.........................................................................................................................253.5.Aspectos éticos.........................................................................................................253.6.Procesamiento de la información........................................................................253.6.1 .Análisis de datos................................................................................................263.6.2.Presentación de los datos.............................................................................264.RESULTADOS...............................................................................................................264.1.Población donante.................................................................................................... 274.1.1. Género y edad...................................................................................................274.2.Población VIH-positiva........................................................................................304.2.1.Edad y género........................................................................................................324.2.2.Estado civil..............................................................................................................354.2.3.Ocupación..............................................................................................................364.2.4.Entidad promotora de salud....................................................................374.2.5.Ciudad de residencia.....................................................................................394.2.6.Tipo de donante......................................................................................415.DISCUSION................................................................................................................426.CONCLUSIONES..................................................................................................467.RECOMENDACIONES..............................................................................................477.RECOMENDACIONES................................................................................................478.REFERENCIAS BIBLIOGRÁFICAS...................................................................489.ANEXOS........................................................................................................................54PregradoBacteriólogo(a