Antibacterial Activities of 5-Nitro-2-uryl and 5-Nitro-2-Imidazolyl Derivatives of 1,3,4-Thiadiazole

Introduction: Nitrofurans and nitroimidazoles are broad-spectrum antimicrobial agents, which affect the microbial DNA. The aim of the present study was to evaluate the new derivatives of these two groups of antimicrobials against certain Gram-positive and Gram-negative bacterial strains. Materials and Methods: Seven new derivatives of nitrofurans and nitroimidazoles were synthesized, and 6.4 mg of each derivative was dissolved in dimethyl sulfoxide. Then, 8 serial dilutions (0.5, 1, 2, 4, 8, 16, 32, and 64 μg/ml) of each derivative was prepared using Muller-Hinton broth, and the minimum inhibitory concentration for each derivative was measured and compared to ciprofloxacin (standard). Results: All the derivatives had no antibacterial effects against Gram-negative bacteria (minimum inhibitory concentration > 64 μg/ml); only 2-(5-nitro-2-furyl)-5-(n-pentylsulfunyl)-1,3,4-thiadiazole exhibited mild antibacterial effects against Klebsiella pneumonia (minimum inhibitory concentration of 16-32 μg/ml). The antibacterial effects of the derivatives against Gram-positive bacteria also showed variations from complete inhibition of the growth of Staphylococcus epidermidis and Bacillus subtilis (minimum inhibitory concentration < 0.5 μg/ml) by 2-(5-nitro-2-furyl)-5-(n-buthylthio)-1,3,4-thiadiazole to no inhibition of S. epidermidis and streptococcus pyogenes. Conclusion: These compounds have weak antibacterial effects; only two derivatives showed antibacterial effects similar to that of the positive control

Antibiotic Self-Medication and Risk Factors among Medical Students in an Iranian University: a Cross Sectional Study

Background: Self-medication with antibiotic is a widely prevalent practice all over the world especially among medical students. This study was aimed to evaluate the prevalence and the pattern of self-medication among medical students in Tehran, Iran. Materials and Methods: A cross-sectional questionnaire-based study was conducted among the undergraduate medical students from a referral university in Tehran, Iran. All data obtained were analyzed using the statistical package for social sciences program (SPSS) version 20. Results: A total of 201 students were enrolled in the current study. According to the analysis, 129 (64.1%) of the study population reported that they have self-medicated with antibiotics at least once in their student life. The principal morbidities for seeking self-medication include cough and common cold (23.4%) followed by fever (14.9%). The most frequent antibiotics used to self-medicate the mentioned morbidities were: amoxicillin (62%), co-amoxiclav (19.4%), penicillin (17%), cefixime (16%), azithromycin (14%) and tetracycline (9%). The majority of the participants stated cost saving, convenience and lack of confidence as their reasons for self-medication. The drug selection was mostly based on opinion of family members (31.8%), their own experience (27.4%) and the least commonly reported was selection based on recommendation by net citizens (0.5%). Conclusion: Our study indicates that self-medication is widely practiced among students of the college. In this situation, the health care system should create as effective awareness and educate their students regarding advantages and disadvantages of self-medication

Patency rate and factors affecting the clinical outcome of patients with aortoiliac artery occlusion undergoing intra-arterial stenting

Background Occluding plaques are commonly found inthe infrarenal aorta and the iliac artery in patients with peripheralarterial disease (PAD). Aortoiliacocclusive disease(AIOD) occurs commonly in patients with PAD.Methods: This is a prospective study was carried out between2015 and 2017 in Sina hospital. Patients with occlusionin aortoiliac artery and its branches were included.Stent was placed for patients, if they had any obstructionor stenosis in aortoiliac artery in angiography. Patientswere examined in terms of clinical status and ABI calculationand underwent Color Doppler ultrasound of aortoiliacartery to determine patency rate at 1, 3, 12, and 24months after stent placement.Results: The mean age of patients was 64.60 (±10.41).The main symptoms of the patients were claudication(41.8%), ulcer (27.3%), pain at rest (20%), and gangrene(20%). The lesion was bilateral in 21 patients (38.2%).According to TASC stratification, lesions were of type A in26 patients (47.3%), type B in 4 patients (7.3%), type Cin 5 patients (9.1%), and type D in 20 patients (36.4%).The six-month, one-year, and two-year patency rates were89.1%, 83.6%, and 72.7%, respectively. The mean annualABI of patients was 0.79 (±0.11) and two year ABIwas 0.68 (±0.1).Conclusion: It seems that stenting and angioplasty areeffective in improving patients’ conditions and result in agood short and medium-term patency

Can chemical burns lead to autoimmune gastritis in the long term?

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Electrocatalytic Oxidation of Ethanol and Ethylene Glycol onto Poly (o-Anisidine)-Nickel Composite Electrode

ABSTRACT: In this work, poly (o- Anisidin

Bioinformatics as an efficient tool and approach for burn wound healing

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Photocatalytic Graphene-TiO2 Thin Films Fabricated by Low-Temperature Ultrasonic Vibration-Assisted Spin and Spray Coating in a Sol-Gel Process

In this work, we communicate a facile and low temperature synthesis process for the fabrication of graphene-TiO2 photocatalytic composite thin films. A sol-gel chemical route is used to synthesize TiO2 from the precursor solutions and spin and spray coating are used to deposit the films. Excitation of the wet films during the casting process by ultrasonic vibration favorably influences both the sol-gel route and the deposition process, through the following mechanisms. The ultrasound energy imparted to the wet film breaks down the physical bonds of the gel phase. As a result, only a low-temperature post annealing process is required to eliminate the residues to complete the conversion of precursors to TiO2. In addition, ultrasonic vibration creates a nanoscale agitating motion or microstreaming in the liquid film that facilitates mixing of TiO2 and graphene nanosheets. The films made based on the above-mentioned ultrasonic vibration-assisted method and annealed at 150 °C contain both rutile and anatase phases of TiO2, which is the most favorable configuration for photocatalytic applications. The photoinduced and photocatalytic experiments demonstrate effective photocurrent generation and elimination of pollutants by graphene-TiO2 composite thin films fabricated via scalable spray coating and mild temperature processing, the results of which are comparable with those made using lab-scale and energy-intensive processes