Mental health trajectories among the general population and higher-risk groups following the COVID-19 pandemic in Switzerland, 2021-2023.

Mental health deteriorated in the early stages of the COVID-19 pandemic, but improved relatively quickly as restrictions were eased, suggesting overall resilience. However, longer-term follow-up of mental health in the general population is scarce. We examined mental health trajectories in 5624 adults (58 % women; aged 18-97 years) from the Specchio-COVID19 cohort, using the Generalized Anxiety Disorder scale-2 and the Patient Health Questionnaire-2, administered each month from February to June 2021, and in Spring 2022 and 2023. Depressive and anxiety symptoms declined during a pandemic wave from February to May 2021 (β = -0.06 [-0.07, -0.06]; -0.06 [-0.07, -0.05]), and remained lower at longer-term follow-up than at the start of the wave. Loneliness also declined over time, with the greatest decline during the pandemic wave (β = -0.25 [-0.26, -0.24]). Many higher-risk groups, including socioeconomically disadvantaged individuals, those with a chronic condition, and those living alone had poorer mental health levels throughout the study period. Women and younger individuals had a faster improvement in mental health during the pandemic wave. Loneliness trajectories were associated with mental health trajectories throughout the study period. We cannot definitively conclude that the observed changes in mental health were due to experiences of the pandemic. While there was a need for additional mental health support during stricter policy responses to COVID-19, overall, mental health improved relatively soon after measures were eased. Nevertheless, the persistence of mental health disparities highlights the need for further efforts from the government and healthcare practitioners to support vulnerable groups beyond the pandemic

Non-Gaussianities in two-field inflation

We study the bispectrum of the curvature perturbation on uniform energy density hypersurfaces in models of inflation with two scalar fields evolving simultaneously. In the case of a separable potential, it is possible to compute the curvature perturbation up to second order in the perturbations, generated on large scales due to the presence of non-adiabatic perturbations, by employing the $\delta N$-formalism, in the slow-roll approximation. In this case, we provide an analytic formula for the nonlinear parameter $f_{NL}$. We apply this formula to double inflation with two massive fields, showing that it does not generate significant non-Gaussianity; the nonlinear parameter at the end of inflation is slow-roll suppressed. Finally, we develop a numerical method for generic two-field models of inflation, which allows us to go beyond the slow-roll approximation and confirms our analytic results for double inflation.Comment: 29 pages, 6 figures. v2, comparison with previous estimates. v3, JCAP version; Revisions based on Referee's comment, corrected typos, added few eqs and refs, conclusions unchange

Primordial Black Holes, Eternal Inflation, and the Inflationary Parameter Space after WMAP5

We consider constraints on inflation driven by a single, minimally coupled scalar field in the light of the WMAP5 dataset, as well as ACBAR and the SuperNova Legacy Survey. We use the Slow Roll Reconstruction algorithm to derive optimal constraints on the inflationary parameter space. The scale dependence in the slope of the scalar spectrum permitted by WMAP5 is large enough to lead to viable models where the small scale perturbations have a substantial amplitude when extrapolated to the end of inflation. We find that excluding parameter values which would cause the overproduction of primordial black holes or even the onset of eternal inflation leads to potentially significant constraints on the slow roll parameters. Finally, we present a more sophisticated approach to including priors based on the total duration of inflation, and discuss the resulting restrictions on the inflationary parameter space.Comment: v2: version published in JCAP. Minor clarifications and references adde

Non-gaussianity from the inflationary trispectrum

We present an estimate for the non-linear parameter \tau_NL, which measures the non-gaussianity imprinted in the trispectrum of the comoving curvature perturbation, \zeta. Our estimate is valid throughout the inflationary era, until the slow-roll approximation breaks down, and takes into account the evolution of perturbations on superhorizon scales. We find that the non-gaussianity is always small if the field values at the end of inflation are negligible when compared to their values at horizon crossing. Under the same assumption, we show that in Nflation-type scenarios, where the potential is a sum of monomials, the non-gaussianity measured by \tau_NL is independent of the couplings and initial conditions.Comment: 15 pages, uses iopart.sty. Replaced with version accepted by JCAP; journal reference adde

Large Nongaussianity from Nonlocal Inflation

We study the possibility of obtaining large nongaussian signatures in the Cosmic Microwave Background in a general class of single-field nonlocal hill-top inflation models. We estimate the nonlinearity parameter f_{NL} which characterizes nongaussianity in such models and show that large nongaussianity is possible. For the recently proposed p-adic inflation model we find that f_{NL} ~ 120 when the string coupling is order unity. We show that large nongaussianity is also possible in a toy model with an action similar to those which arise in string field theory.Comment: 27 pages, no figures. Added references and some clarifying remark

Classical approximation to quantum cosmological correlations

We investigate up to which order quantum effects can be neglected in calculating cosmological correlation functions after horizon exit. As a toy model, we study $\phi^3$ theory on a de Sitter background for a massless minimally coupled scalar field $\phi$. We find that for tree level and one loop contributions in the quantum theory, a good classical approximation can be constructed, but for higher loop corrections this is in general not expected to be possible. The reason is that loop corrections get non-negligible contributions from loop momenta with magnitude up to the Hubble scale H, at which scale classical physics is not expected to be a good approximation to the quantum theory. An explicit calculation of the one loop correction to the two point function, supports the argument that contributions from loop momenta of scale $H$ are not negligible. Generalization of the arguments for the toy model to derivative interactions and the curvature perturbation leads to the conclusion that the leading orders of non-Gaussian effects generated after horizon exit, can be approximated quite well by classical methods. Furthermore we compare with a theorem by Weinberg. We find that growing loop corrections after horizon exit are not excluded, even in single field inflation.Comment: 44 pages, 1 figure; v2: corrected errors, added references, conclusions unchanged; v3: added section in which we compare with stochastic approach; this version matches published versio

Outer-Sphere Contributions to the Electronic Structure of Type Zero Copper Proteins

Bioinorganic canon states that active-site thiolate coordination promotes rapid electron transfer (ET) to and from type 1 copper proteins. In recent work, we have found that copper ET sites in proteins also can be constructed without thiolate ligation (called “type zero” sites). Here we report multifrequency electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD), and nuclear magnetic resonance (NMR) spectroscopic data together with density functional theory (DFT) and spectroscopy-oriented configuration interaction (SORCI) calculations for type zero Pseudomonas aeruginosa azurin variants. Wild-type (type 1) and type zero copper centers experience virtually identical ligand fields. Moreover, O-donor covalency is enhanced in type zero centers relative that in the C112D (type 2) protein. At the same time, N-donor covalency is reduced in a similar fashion to type 1 centers. QM/MM and SORCI calculations show that the electronic structures of type zero and type 2 are intimately linked to the orientation and coordination mode of the carboxylate ligand, which in turn is influenced by outer-sphere hydrogen bonding

The inflationary trispectrum

We calculate the trispectrum of the primordial curvature perturbation generated by an epoch of slow-roll inflation in the early universe, and demonstrate that the non-gaussian signature imprinted at horizon crossing is unobservably small, of order tau_NL < r/50, where r < 1 is the tensor-to-scalar ratio. Therefore any primordial non-gaussianity observed in future microwave background experiments is likely to have been synthesized by gravitational effects on superhorizon scales. We discuss the application of Maldacena's consistency condition to the trispectrum.Comment: 23 pages, 2 diagrams drawn with feynmp.sty, uses iopart.cls. v2, replaced with version accepted by JCAP. Estimate of maximal tau_NL refined in Section 5, resulting in smaller numerical value. Sign errors in Eq. (44) and Eq. (48) corrected. Some minor notational change

Diagrammatic approach to non-Gaussianity from inflation

We present Feynman type diagrams for calculating the n-point function of the primordial curvature perturbation in terms of scalar field perturbations during inflation. The diagrams can be used to evaluate the corresponding terms in the n-point function at tree level or any required loop level. Rules are presented for drawing the diagrams and writing down the corresponding terms in real space and Fourier space. We show that vertices can be renormalised to automatically account for diagrams with dressed vertices. We apply these rules to calculate the primordial power spectrum up to two loops, the bispectrum including loop corrections, and the trispectrum.Comment: 17 pages, 13 figures. v2: Comments and references added, v3: Introduction expanded, subsection on evaluating loop diagrams added, minor errors corrected, references adde