52 research outputs found
Mental health trajectories among the general population and higher-risk groups following the COVID-19 pandemic in Switzerland, 2021-2023.
Mental health deteriorated in the early stages of the COVID-19 pandemic, but improved relatively quickly as restrictions were eased, suggesting overall resilience. However, longer-term follow-up of mental health in the general population is scarce.
We examined mental health trajectories in 5624 adults (58 % women; aged 18-97 years) from the Specchio-COVID19 cohort, using the Generalized Anxiety Disorder scale-2 and the Patient Health Questionnaire-2, administered each month from February to June 2021, and in Spring 2022 and 2023.
Depressive and anxiety symptoms declined during a pandemic wave from February to May 2021 (ÎČ = -0.06 [-0.07, -0.06]; -0.06 [-0.07, -0.05]), and remained lower at longer-term follow-up than at the start of the wave. Loneliness also declined over time, with the greatest decline during the pandemic wave (ÎČ = -0.25 [-0.26, -0.24]). Many higher-risk groups, including socioeconomically disadvantaged individuals, those with a chronic condition, and those living alone had poorer mental health levels throughout the study period. Women and younger individuals had a faster improvement in mental health during the pandemic wave. Loneliness trajectories were associated with mental health trajectories throughout the study period.
We cannot definitively conclude that the observed changes in mental health were due to experiences of the pandemic.
While there was a need for additional mental health support during stricter policy responses to COVID-19, overall, mental health improved relatively soon after measures were eased. Nevertheless, the persistence of mental health disparities highlights the need for further efforts from the government and healthcare practitioners to support vulnerable groups beyond the pandemic
Non-Gaussianities in two-field inflation
We study the bispectrum of the curvature perturbation on uniform energy
density hypersurfaces in models of inflation with two scalar fields evolving
simultaneously. In the case of a separable potential, it is possible to compute
the curvature perturbation up to second order in the perturbations, generated
on large scales due to the presence of non-adiabatic perturbations, by
employing the -formalism, in the slow-roll approximation. In this
case, we provide an analytic formula for the nonlinear parameter . We
apply this formula to double inflation with two massive fields, showing that it
does not generate significant non-Gaussianity; the nonlinear parameter at the
end of inflation is slow-roll suppressed. Finally, we develop a numerical
method for generic two-field models of inflation, which allows us to go beyond
the slow-roll approximation and confirms our analytic results for double
inflation.Comment: 29 pages, 6 figures. v2, comparison with previous estimates. v3, JCAP
version; Revisions based on Referee's comment, corrected typos, added few eqs
and refs, conclusions unchange
Primordial Black Holes, Eternal Inflation, and the Inflationary Parameter Space after WMAP5
We consider constraints on inflation driven by a single, minimally coupled
scalar field in the light of the WMAP5 dataset, as well as ACBAR and the
SuperNova Legacy Survey. We use the Slow Roll Reconstruction algorithm to
derive optimal constraints on the inflationary parameter space. The scale
dependence in the slope of the scalar spectrum permitted by WMAP5 is large
enough to lead to viable models where the small scale perturbations have a
substantial amplitude when extrapolated to the end of inflation. We find that
excluding parameter values which would cause the overproduction of primordial
black holes or even the onset of eternal inflation leads to potentially
significant constraints on the slow roll parameters. Finally, we present a more
sophisticated approach to including priors based on the total duration of
inflation, and discuss the resulting restrictions on the inflationary parameter
space.Comment: v2: version published in JCAP. Minor clarifications and references
adde
Non-gaussianity from the inflationary trispectrum
We present an estimate for the non-linear parameter \tau_NL, which measures
the non-gaussianity imprinted in the trispectrum of the comoving curvature
perturbation, \zeta. Our estimate is valid throughout the inflationary era,
until the slow-roll approximation breaks down, and takes into account the
evolution of perturbations on superhorizon scales. We find that the
non-gaussianity is always small if the field values at the end of inflation are
negligible when compared to their values at horizon crossing. Under the same
assumption, we show that in Nflation-type scenarios, where the potential is a
sum of monomials, the non-gaussianity measured by \tau_NL is independent of the
couplings and initial conditions.Comment: 15 pages, uses iopart.sty. Replaced with version accepted by JCAP;
journal reference adde
Large Nongaussianity from Nonlocal Inflation
We study the possibility of obtaining large nongaussian signatures in the
Cosmic Microwave Background in a general class of single-field nonlocal
hill-top inflation models. We estimate the nonlinearity parameter f_{NL} which
characterizes nongaussianity in such models and show that large nongaussianity
is possible. For the recently proposed p-adic inflation model we find that
f_{NL} ~ 120 when the string coupling is order unity. We show that large
nongaussianity is also possible in a toy model with an action similar to those
which arise in string field theory.Comment: 27 pages, no figures. Added references and some clarifying remark
Classical approximation to quantum cosmological correlations
We investigate up to which order quantum effects can be neglected in
calculating cosmological correlation functions after horizon exit. As a toy
model, we study theory on a de Sitter background for a massless
minimally coupled scalar field . We find that for tree level and one loop
contributions in the quantum theory, a good classical approximation can be
constructed, but for higher loop corrections this is in general not expected to
be possible. The reason is that loop corrections get non-negligible
contributions from loop momenta with magnitude up to the Hubble scale H, at
which scale classical physics is not expected to be a good approximation to the
quantum theory. An explicit calculation of the one loop correction to the two
point function, supports the argument that contributions from loop momenta of
scale are not negligible. Generalization of the arguments for the toy model
to derivative interactions and the curvature perturbation leads to the
conclusion that the leading orders of non-Gaussian effects generated after
horizon exit, can be approximated quite well by classical methods. Furthermore
we compare with a theorem by Weinberg. We find that growing loop corrections
after horizon exit are not excluded, even in single field inflation.Comment: 44 pages, 1 figure; v2: corrected errors, added references,
conclusions unchanged; v3: added section in which we compare with stochastic
approach; this version matches published versio
Outer-Sphere Contributions to the Electronic Structure of Type Zero Copper Proteins
Bioinorganic canon states that active-site
thiolate coordination promotes rapid electron transfer (ET)
to and from type 1 copper proteins. In recent work, we have
found that copper ET sites in proteins also can be constructed
without thiolate ligation (called âtype zeroâ sites). Here we
report multifrequency electron paramagnetic resonance
(EPR), magnetic circular dichroism (MCD), and nuclear
magnetic resonance (NMR) spectroscopic data together with
density functional theory (DFT) and spectroscopy-oriented
configuration interaction (SORCI) calculations for type zero Pseudomonas aeruginosa azurin variants. Wild-type (type 1) and type
zero copper centers experience virtually identical ligand fields. Moreover, O-donor covalency is enhanced in type zero centers
relative that in the C112D (type 2) protein. At the same time, N-donor covalency is reduced in a similar fashion to type 1
centers. QM/MM and SORCI calculations show that the electronic structures of type zero and type 2 are intimately linked to the
orientation and coordination mode of the carboxylate ligand, which in turn is influenced by outer-sphere hydrogen bonding
The inflationary trispectrum
We calculate the trispectrum of the primordial curvature perturbation
generated by an epoch of slow-roll inflation in the early universe, and
demonstrate that the non-gaussian signature imprinted at horizon crossing is
unobservably small, of order tau_NL < r/50, where r < 1 is the tensor-to-scalar
ratio. Therefore any primordial non-gaussianity observed in future microwave
background experiments is likely to have been synthesized by gravitational
effects on superhorizon scales. We discuss the application of Maldacena's
consistency condition to the trispectrum.Comment: 23 pages, 2 diagrams drawn with feynmp.sty, uses iopart.cls. v2,
replaced with version accepted by JCAP. Estimate of maximal tau_NL refined in
Section 5, resulting in smaller numerical value. Sign errors in Eq. (44) and
Eq. (48) corrected. Some minor notational change
One-loop corrections to the curvature perturbation from inflation
An estimate of the one-loop correction to the power spectrum of the
primordial curvature perturbation is given, assuming it is generated during a
phase of single-field, slow-roll inflation. The loop correction splits into two
parts, which can be calculated separately: a purely quantum-mechanical
contribution which is generated from the interference among quantized field
modes around the time when they cross the horizon, and a classical contribution
which comes from integrating the effect of field modes which have already
passed far beyond the horizon. The loop correction contains logarithms which
may invalidate the use of naive perturbation theory for cosmic microwave
background (CMB) predictions when the scale associated with the CMB is
exponentially different from the scale at which the fundamental theory which
governs inflation is formulated.Comment: 28 pages, uses feynmp.sty and ioplatex journal style. v2: supersedes
version published in JCAP. Some corrections and refinements to the discussion
and conclusions. v3: Corrects misidentification of quantum correction with an
IR effect. Improvements to the discussio
- âŠ