Comparing Galaxies and Lyman Alpha Absorbers at Low Redshift

A scenario is explored in which Lyman alpha absorbers at low redshift arise from lines of sight through extended galaxy disks, including those of dwarf and low surface brightness galaxies. A population of galaxies is simulated based upon observed distributions of galaxy properties, and the gas disks are modeled using pressure and gravity confinement. Some parameter values are ruled out by comparing simulation results with the observed galaxy luminosity function, and constraints may be made on the absorbing cross sections of galaxies. Simulation results indicate that it is difficult to match absorbers with particular galaxies observationally since absorption typically occurs at high impact parameters (>200 kpc) from luminous galaxies. Low impact parameter absorption is dominated by low luminosity dwarfs. A large fraction of absorption lines is found to originate from low surface brightness galaxies, so that the absorbing galaxy is likely to be misidentified. Low redshift Lyman alpha absorber counts can easily be explained by moderately extended galaxy disks when low surface brightness galaxies are included, and it is easily possible to find a scenario which is consistent with observed the galaxy luminosity function, with low redshift Lyman limit absorber counts, and with standard nucleosynthesis predictions of the baryon density, Omega_Baryon.Comment: 17 pages, 8 figures, accepted to the Astrophysical Journa

Neutral atomic hydrogen (H i) gas evolution in field galaxies at z similar to 0.1 and similar to 0.2

<p>We measure the neutral atomic hydrogen (H i) gas content of field galaxies at intermediate redshifts of z similar to 0.1 and similar to 0.2 using hydrogen 21-cm emission lines observed with the Westerbork Synthesis Radio Telescope. In order to make high signal-to-noise ratio detections, an H i signal stacking technique is applied: H i emission spectra from multiple galaxies, optically selected by the second Canadian Network for Observational Cosmology redshift survey project, are co-added to measure the average H i mass of galaxies in the two redshift bins. We calculate the cosmic H i gas densities ((Hi)) at the two redshift regimes and compare those with measurements at other redshifts to investigate the global evolution of the H i gas density over cosmic time. From a total of 59 galaxies at z similar to 0.1 we find (Hi) = (0.33 +/- 0.05) x 10(-3), and at z similar to 0.2 we find (Hi) = (0.34 +/- 0.09) x 10(-3), based on 96 galaxies. These measurements help bridge the gap between high-z damped Lyman alpha observations and blind 21-cm surveys at z = 0. We find that our measurements of (Hi) at z similar to 0.1 and similar to 0.2 are consistent with the H i gas density at z similar to 0 and that all measurements of (Hi) from 21-cm emission observations at z less than or similar to 0.2 are in agreement with no evolution of the H i gas content in galaxies during the last 2.4 Gyr.</p>

Specialty-based, voluntary incident reporting in neonatal intensive care: description of 4846 incident reports

OBJECTIVES: To examine the characteristics of incidents reported after introduction of a voluntary, non-punitive incident reporting system for neonatal intensive care units (NICUs) in the Netherlands; and to investigate which types of reported incident pose the highest risk to patients in the NICU. DESIGN: Prospective multicentre survey. METHODS: Voluntary, non-punitive incident reporting was introduced in eight level III NICUs and one paediatric surgical ICU. An incident was defined as any unintended event which (could have) reduced the safety margin for the patient. Multidisciplinary, unit-based patient safety committees systematically collected and analysed incident reports, and assigned risk scores to each reported incident. Data were centrally collected for specialty-based analysis. This paper describes the characteristics of incidents reported during the first year. Bivariate logistic regression analysis was conducted to identify high-risk incident categories. RESULTS: There were 5225 incident reports on 3859 admissions, of which 4846 were eligible for analysis. Incidents with medication were most frequently reported (27%), followed by laboratory (10%) and enteral nutrition (8%). Severe harm was described in seven incident reports, and moderate harm in 63 incident reports. Incidents involving mechanical ventilation and blood products were most likely to be assigned high-risk scores, followed by those involving parenteral nutrition, intravascular lines and medication dosing errors. CONCLUSIONS: Incidents occur much more frequently in Dutch NICUs than has been previously observed, and their impact on patient morbidity is considerable. Reported incidents concerning mechanical ventilation, blood products, intravascular lines, parenteral nutrition and medication dosing errors pose the highest risk to patients in the NIC

Feasibility and reliability of PRISMA-Medical for specialty-based incident analysis

Aims and objectives: In this study, the feasibility and reliability of the Prevention Recovery Information System for Monitoring and Analysis (PRISMA)-Medical method for systematic, specialty-based analysis and classification of incidents in the neonatal intensive care unit (NICU) were determined. Methods: After the introduction of a Neonatology System for Analysis and Feedback on Medical Events (NEOSAFE) in eight tertiary care NICUs and one paediatric surgical ICU, PRISMA-Medical was started to be used to identify root causes of voluntary reported incidents by multidisciplinary unit patient safety committees. Committee members were PRISMA-trained and familiar with the department and its processes. In this study, the results of PRISMA-analysis of incidents reported during the first year are described. At t¿=¿3 months and t¿=¿12 months after introduction, test cases were performed to measure agreement at three levels of root cause classification using PRISMA-Medical. Inter-rater reliability was determined by calculating generalised ¿ values for each level of classification. Results: During the study period, 981 out of 1786 eligible incidents (55%) were analysed for underlying root causes. In total, 2313 root causes were identified and classified, giving an average of 2.4 root causes for every incident. Although substantial agreement (¿ 0.70–0.81) was reached at the main level of root cause classification of the test cases (discrimination between technical, organisational and human failure) and agreement among the committees at the second level (discrimination between skill-based, rule-based and knowledge-based errors) was acceptable (¿ 0.53–0.59), discrimination between rule-based errors (the third level of classification) was more difficult to assess (¿ 0.40–0.47). Conclusion: With some restraints, PRISMA-Medical proves to be both feasible and acceptably reliable to identify and classify multiple causes of medical events in the NICU

Reconciling the local galaxy population with damped Ly-alpha cross sections and metal abundances

A comprehensive analysis of 355 high-quality WSRT HI 21-cm line maps of nearby galaxies shows that the properties and incident rate of Damped Lyman-alpha (DLA) absorption systems observed in the spectra of high redshift QSOs are in good agreement with DLAs originating in gas disks of galaxies like those in the z~0 population. Comparison of low-z DLA statistics with the HI incidence rate and column density distribution f(N) for the local galaxy sample shows no evidence for evolution in the integral "cross section density" below z~1.5, implying that there is no need for a hidden population of galaxies or HI clouds to contribute significantly to the DLA cross section. Compared with z~4, our data indicates evolution of a factor of two in the comoving density along a line of sight. We find that dN/dz(z=0)=0.045 +/- 0.006. The idea that the local galaxy population can explain the DLAs is further strengthened by comparing the properties of DLAs and DLA galaxies with the expectations based on our analysis of local galaxies. The distribution of luminosities of DLA host galaxies, and of impact parameters between QSOs and the centres of DLA galaxies, are in good agreement with what is expected from local galaxies. Approximately 87% of low z DLA galaxies are expected to be fainter than L* and 37 per cent have impact parameters less than 1'' at z=0.5. The analysis shows that some host galaxies with very low impact parameters and low luminosities are expected to be missed in optical follow up surveys. The well-known metallicity-luminosity relation in galaxies, in combination with metallicity gradients in galaxy disks, cause the expected median metallicity of low redshift DLAs to be low (~1/7 solar), which is also in good agreement with observations of low z DLAs. (Abridged)Comment: 22 pages, 22 figures. Accepted for publication in MNRAS. Fixed typo

Normal Globular Cluster Systems in Massive Low Surface Brightness Galaxies

We present the results of a study of the globular cluster systems of 6 massive spiral galaxies, originally cataloged as low surface brightness galaxies but here shown to span a wide range of central surface brightness values, including two intermediate to low surface brightness galaxies. We used the Advanced Camera for Surveys on board HST to obtain photometry in the F475W and F775W bands and select sources with photometric and morphological properties consistent with those of globular clusters. A total of 206 candidates were identified in our target galaxies. From a direct comparison with the Galactic globular cluster system we derive specific frequency values for each galaxy that are in the expected range for late-type galaxies. We show that the globular cluster candidates in all galaxies have properties consistent with globular cluster systems of previously studied galaxies in terms of luminosity, sizes and color. We establish the presence of globular clusters in the two intermediate to low surface brightness galaxies in our sample and show that their properties do not have any significant deviation from the behavior observed in the other sample galaxies. Our results are broadly consistent with a scenario in which low surface brightness galaxies follow roughly the same evolutionary history as normal (i.e. high surface) brightness galaxies except at a much lower rate, but require the presence of an initial period of star formation intense enough to allow the formation of massive star clusters.Comment: 14 pages, 6 figures. AJ accepte

Standardised immunophenotypic analysis of myeloperoxidase in acute leukaemia

© The Authors.Given its myeloid-restricted expression, myeloperoxidase (MPO) is typically used for lineage assignment (myeloid vs. lymphoid) during acute leukaemia (AL) diagnostics. In the present study, a robust flow cytometric definition for MPO positivity was established based on the standardised EuroFlow protocols, the standardised Acute Leukaemia Orientation Tube and 1734 multicentre AL cases (with confirmed assay stability). The best diagnostic performance was achieved by defining MPO positivity as ≥20% of the AL cells exceeding a lymphocyte-based threshold. The methodology employed should be applicable to any form of standardised flow cytometry.The co-ordination of this study was supported by the EuroFlow Consortium. The EuroFlow Consortium received support from the FP6-2004-LIFESCIHEALTH-5 programme of the European Commission (grant LSHB-CT-2006-018708) as Specific Targeted Research Project (STREP). The EuroFlow Consortium is part of the European Scientific Foundation for Hemato-Oncology (ESLHO), a Scientific Working Group (SWG) of the European Hematology Association (EHA)

Testing the Hypothesis of Modified Dynamics with Low Surface Brightness Galaxies and Other Evidence

The rotation curves of low surface brightness galaxies provide a unique data set with which to test alternative theories of gravitation over a large dynamic range in size, mass, surface density, and acceleration. Many clearly fail, including any in which the mass discrepancy appears at a particular length-scale. One hypothesis, MOND [Milgrom 1983, ApJ, 270, 371], is consistent with the data. Indeed, it accurately predicts the observed behavior. We find no evidence on any scale which clearly contradicts MOND, and a good deal which supports it.Comment: Accepted for publication in the Astrophysical Journal. 35 pages AAStex + 9 figures. This result surprised the bejeepers out of us, to