15 research outputs found
Atypical clinical presentation and long-term survival in a patient with optic nerve medulloepithelioma: a case report
<p>Abstract</p> <p>Introduction</p> <p>Medulloepithelioma is a rare congenital tumor of the primitive medullary neuroepithelium. A significant proportion of patients with medulloepithelioma arising from the optic nerve die from intracranial spread or cerebral metastasis. Because it has no known distinct clinical features and because of its low frequency, this tumor presents within the first two to six years of life and is usually misdiagnosed clinically as a different type of optic nerve tumor. Here, we describe a new and atypical case of medulloepithelioma of the optic nerve in a 12-year-old boy. To the best of our knowledge, he is the oldest reported patient to present with this disease and, now as an adult, has the longest documented period of disease-free survival.</p> <p>Case presentation</p> <p>A 12-year-old Caucasian boy with headache and unilateral amaurosis was referred for a presumed optic nerve glioma to our hospital. A computed tomography scan showed optic nerve enlargement, and fundoscopy showed a whitish mass at the optic disc. Our patient had been followed at his local hospital for four years for an 'optic disc cyst' with no change or progression. He experienced mild progressive visual impairment during that period. He was admitted for resection, and a histopathological analysis revealed a medulloepithelioma of the optic nerve. Supplemental orbital radiotherapy was performed. He remained disease-free for 25 years.</p> <p>Conclusions</p> <p>Medulloepithelioma of the optic nerve can clinically mimic more common pediatric tumors, such as optic glioma, meningioma, or retinoblastoma. Thus, medulloepithelioma should be included in the differential diagnoses of pediatric optic nerve lesions. Fundoscopy in these patients may provide relevant information for diagnosis. Anterior optic nerve medulloepitheliomas may behave differently from and have a better prognosis than medulloepitheliomas that have a more posterior location. Our case report illustrates that long-term survival can be achieved in patients with this malignant tumor.</p
Indicadores para Centros de ReferĂȘncia em SaĂșde do Trabalhador: proposição de um sistema de acompanhamento de serviços de saĂșde
Alcohol Use and Church Attendance Among Seventh Through Twelfth Grade Students, Dominican Republic, 2011
Posterior uveal melanoma in adolescents and children: current perspectives
Matthew V Fry,1 James J Augsburger,1 June Hall,2 Zélia M Corrêa21Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA; 2Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: Recognizing that <1% of all uveal melanomas occur in young persons, and that very few clinicians encounter more than a few such cases over an extended career, we felt that a retrospective review of literature and sharing of our clinical experience would be appropriate to remind readers about this age subgroup of patients with posterior uveal melanoma. This interest stems from the increase in reported cases of uveal melanoma in younger individuals and recent advances in the field. Keywords: uveal melanoma, choroid melanoma, ciliary body melanoma, posterior uveal melanoma, prognosis melanoma, incidenc
Atributos fĂsicos do solo, adubado com lodo de esgoto e silicato de cĂĄlcio e magnĂ©sio
Este trabalho teve como objetivo avaliar o efeito da aplicação de lodo de esgoto e de silicato de cĂĄlcio e magnĂ©sio sobre os atributos fĂsicos de um Cambissolo HĂĄplico, cultivado com girassol. Os tratamentos foram distribuĂdos em esquema fatorial (4 x 2) + 1, correspondendo a quatro doses de lodo de esgoto desidratado (0; 6,25; 12,5 e 18,5 t ha-1), duas doses de silicato de cĂĄlcio e magnĂ©sio (0 e 240 g m-1) e um tratamento adicional com adubação mineral. O delineamento utilizado foi em blocos casualizados, com trĂȘs repetiçÔes. ApĂłs 150 dias da adubação, coletaram-se amostras de solos, nas camadas de 0-20 e 20-40 cm, para avaliação da densidade aparente, densidade de partĂcula, porosidade total, grau de dispersĂŁo, grau de floculação, Ăndice de estabilidade de agregados, diĂąmetro mĂ©dio ponderado, diĂąmetro mĂ©dio geomĂ©trico e resistĂȘncia do solo Ă penetração. O tratamento adicional, correspondente Ă adubação mineral, nĂŁo diferiu dos tratamentos correspondentes Ă s adubaçÔes com lodo de esgoto e silicato de cĂĄlcio e magnĂ©sio, em relação aos atributos fĂsicos do solo. Para o silicato de cĂĄlcio e magnĂ©sio, tambĂ©m nĂŁo se constataram diferenças nos atributos fĂsicos do solo, entre a dose zero e 240 g m-1. Por outro lado, a aplicação de lodo de esgoto diminuiu o grau de dispersĂŁo de argila e aumentou a porosidade total do solo, o grau de floculação de argilas e o Ăndice de estabilidade de agregados a Ășmido, nĂŁo tendo, porĂ©m, influenciado os demais atributos fĂsicos