Clinical observation and management of COVID-19 patients

Three leading infectious disease experts in China were invited to share their bedside observations in the management of COVID-19 patients. Professor Taisheng Li was sent to Wuhan to provide frontline medical care. He depicts the clinical course of SARS-CoV-2 infection. Furthermore, he observes the significant abnormality of coagulation function and proposes that the early intravenous immunoglobulin and low molecular weight heparin anticoagulation therapy are very important. Professor Hongzhou Lu, a leader in China to try various anti-viral drugs, expresses concern on the quality of the ongoing clinical trials as most trials are small in scale and repetitive in nature, and emphasizes the importance of the quick publication of clinical trial results. Regarding the traditional Chinese medicine, Professor Lu suggests to develop a creative evaluation system because of the complicated chemical compositions. Professor Wenhong Zhang is responsible for Shanghai’s overall clinical management of the COVID-19 cases. He introduces the team approach to manage COVID-19 patients. For severe or critically ill patients, in addition to the respiratory supportive treatment, timely multiorgan evaluation and treatment is very crucial. The medical decisions and interventions are carefully tailored to the unique characteristics of each patient

On the switching mechanism and optimisation of ion irradiation enabled 2D MoS2MoS_2 memristors

Memristors are prominent passive circuit elements with promising futures for energy-efficient in-memory processing and revolutionary neuromorphic computation. State-of-the-art memristors based on two-dimensional (2D) materials exhibit enhanced tunability, scalability and electrical reliability. However, the fundamental of the switching is yet to be clarified before they can meet industrial standards in terms of endurance, variability, resistance ratio, and scalability. This new physical simulator based on the kinetic Monte Carlo (kMC) algorithm reproduces the defect migration process in 2D materials and sheds light on the operation of 2D memristors. The present work employs the simulator to study a two-dimensional $2H-MoS_2$ planar resistive switching (RS) device with an asymmetric defect concentration introduced by ion irradiation. The simulations unveil the non-filamentary RS process and propose practical routes to optimize the device's performance. For instance, the resistance ratio can be increased by 53% by controlling the concentration and distribution of defects, while the variability can be reduced by 55% by increasing 5-fold the device size from 10 to 50 nm. Our simulator also explains the trade-offs between the resistance ratio and variability, resistance ratio and scalability, and variability and scalability. Overall, the simulator may enable an understanding and optimization of devices to expedite cutting-edge applications.Comment: 8 pages (double column), 6 figures, Supplementary Information (9 figures

Development of Biofuels in China: Progress, Government Policies and Future Prospects

China is the largest energy consumer in the world, but has limited energy resources. Energy security is thus a primary concern for China. Over reliance on the consumption of fossil energy has resulted in severe environmental pollution, which puts pressure on the government to adjust its energy mix. To strengthen its energy supply and prevent further environmental degradation, China has been committed to developing renewable energies, such as biofuels. This article provides a comprehensive assessment of the development of biofuels, rural household biogas, and bioethanol, in particular. It also examines related government policies and the future prospects of the biofuel sector. The analysis shows that remarkable achievements have been made in the development of biogas in rural areas and in bioethanol at the industrial level. This progress is largely credited to government's strong support for the biofuel sectors. Nonetheless, although ongoing energy insecurity and environmental pollution continues to motivate the central government to support the development of biofuels, widening domestic food supply and demand gap, changes in rural life and agricultural industrialization constrain the further expansion of rural household biogas and cereal-based bioethanol. This article suggests that while China urgently needs to find alternative feedstock for the existing rural household biogas digesters and bioethanol plants, centralized biogas and non-cereal-based bioethanol projects should be prioritized for future development

FRIOD: a deeply integrated feature-rich interactive system for effective and efficient outlier detection

In this paper, we propose an novel interactive outlier detection system called feature-rich interactive outlier detection (FRIOD), which features a deep integration of human interaction to improve detection performance and greatly streamline the detection process. A user-friendly interactive mechanism is developed to allow easy and intuitive user interaction in all the major stages of the underlying outlier detection algorithm which includes dense cell selection, location-aware distance thresholding, and final top outlier validation. By doing so, we can mitigate the major difficulty of the competitive outlier detection methods in specifying the key parameter values, such as the density and distance thresholds. An innovative optimization approach is also proposed to optimize the grid-based space partitioning, which is a critical step of FRIOD. Such optimization fully considers the high-quality outliers it detects with the aid of human interaction. The experimental evaluation demonstrates that FRIOD can improve the quality of the detected outliers and make the detection process more intuitive, effective, and efficient

Beyond Worst-Case Analysis in Stochastic Approximation: Moment Estimation Improves Instance Complexity

We study oracle complexity of gradient based methods for stochastic approximation problems. Though in many settings optimal algorithms and tight lower bounds are known for such problems, these optimal algorithms do not achieve the best performance when used in practice. We address this theory-practice gap by focusing on instance-dependent complexity instead of worst case complexity. In particular, we first summarize known instance-dependent complexity results and categorize them into three levels. We identify the domination relation between different levels and propose a fourth instance-dependent bound that dominates existing ones. We then provide a sufficient condition according to which an adaptive algorithm with moment estimation can achieve the proposed bound without knowledge of noise levels. Our proposed algorithm and its analysis provide a theoretical justification for the success of moment estimation as it achieves improved instance complexity