Central Nervous System Changes in Pediatric Heart Failure: A Volumetric Study

Autonomic dysfunction, mood disturbances, and memory deficits appear in pediatric and adult heart failure (HF). Brain areas controlling these functions show injury in adult HF patients, many of whom have comorbid cerebrovascular disease. We examined whether similar brain pathology develops in pediatric subjects without such comorbidities. In this study, high-resolution T1 brain magnetic resonance images were collected from seven severe HF subjects age (age 8–18 years [mean 13]; left ventricular shortening 9 to 19% [median 14%]) and seven age-matched healthy controls (age 8–18 years [mean 13]). After segmentation into gray matter (GM), white matter, and cerebrospinal fluid (CSF), regional volume loss between groups was determined by voxel-based morphometry. GM volume loss appeared on all HF scans, but ischemic changes and infarcts were absent. HF subjects showed greater CSF volume than controls (mean ± SD 0.30 ± 0.04 vs. 0.25 ± 0.04 l, P = 0.03), but total intracranial volume was identical (1.39 ± 0.11 vs. 1.39 ± 0.09 l, P = NS). Regional GM volume reduction appeared in the right and left posterior hippocampus, bilateral mid-insulae, and the superior medial frontal gyrus and mid-cingulate cortex of HF subjects (threshold P < 0.001). No volume-loss sites appeared in control brains. We conclude that pediatric HF patients show brain GM loss in areas similar to those of adult HF subjects. Substantial changes emerged in sites that regulate autonomic function as well as mood, personality and short-term memory. In the absence of thromboembolic disease and many comorbid conditions found in adult HF patients, pediatric HF patients show significant, focal GM volume loss, which may coincide with the multiple neurologic and psychological changes observed in patients with HF

First demonstration of ionization cooling by the muon ionization cooling experiment

High-brightness muon beams of energy comparable to those produced by state-of-the-art electron, proton and ion accelerators have yet to be realised. Such beams have the potential to carry the search for new phenomena in lepton-antilepton collisions to extremely high energy and also to provide uniquely well-characterised neutrino beams. A muon beam may be created through the decay of pions produced in the interaction of a proton beam with a target. To produce a high-brightness beam from such a source requires that the phase space volume occupied by the muons be reduced (cooled). Ionization cooling is the novel technique by which it is proposed to cool the beam. The Muon Ionization Cooling Experiment collaboration has constructed a section of an ionization cooling cell and used it to provide the first demonstration of ionization cooling. We present these ground-breaking measurements

Multiple Coulomb scattering of muons in lithium hydride

Copyright © 2022 the author(s). Multiple Coulomb scattering (MCS) is a well-known phenomenon occurring when charged particles traverse materials. Measurements of muons traversing low Z materials made in the MuScat experiment showed that theoretical models and simulation codes, such as GEANT4 (v7.0), over-estimated the scattering. The Muon Ionization Cooling Experiment (MICE) measured the cooling of a muon beam traversing a liquid hydrogen or lithium hydride (LiH) energy absorber as part of a programme to develop muon accelerator facilities, such as a neutrino factory or a muon collider. The energy loss and MCS that occur in the absorber material are competing effects that alter the performance of the cooling channel. Therefore measurements of MCS are required in order to validate the simulations used to predict the cooling performance in future accelerator facilities. We report measurements made in the MICE apparatus of MCS using a LiH absorber and muons within the momentum range 160 to 245 MeV=c. The measured RMS scattering width is about 9% smaller than that predicted by the approximate formula proposed by the Particle Data Group, but within the latter’s stated uncertainty. Data at 172, 200 and 240 MeV=c are compared to the GEANT4 (v9.6) default scattering model. These measurements show agreement with this more recent GEANT4 (v9.6) version over the range of incident muon momenta.SCOAP