Reduction of trichloromethyl to gem-dichloromethyl group with triphenylphosphine and water in ethyl acetate

En este trabajo se reporta un método de reducción de triclorometil compuestos bajo condiciones amigables al medio ambiente.A novel and efficient way of reducing trichloromethyl to gem-dichloromethyl compounds using environmentally friendly conditions has been developed. This reduction process consists of the treatment of a trichloromethyl compound with water and triphenylphosphine using ethyl acetate as solvent. This reaction proceeds in good yield when a strong electron-withdrawing group is attached to the trichloromethyl derivative.Conacy

Synthesis of 5-substituted 2-pyrrolidinones by coupling of organozinc reagents with cyclic N-acyliminium ions

En el presente trabajo se describe un procedimiento simple y fácil para la preparación de pirrolidinonas 5-sustituidas a partir de un acoplamiento entre iones N-aciliminio y reactivos organometálicos derivados de zincA coupling reaction between cyclic N-acyliminium ions with organozinc reagents is described. The cyclic N-acyliminium ions, generated in situ from N-substituted-5-hydroxy-2-pyrrolidinones by treatment with BF3-etherate or titanium tetrachloride, were trapped by the organozinc reagent, formed by the alkylbromide in the presence of zinc in the same reaction media. The N-substituted 5-allyl-2-pyrrolidinones generated using this method, serves as versatile intermediates for the synthesis of azabicyclic systems with indolizidine and pyrroloazepinolizidine cores

A Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution

En el presente manuscrito se presenta un método nuevo para la preparación de tetracloropirimidinas y se presenta un estudio acerca de su reactividad química.A convenient two-step synthesis of 2-trichloromethyl-4-chloropyrimidines starting from 2-trichloromethyl-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared in one pot synthesis by a sequential acylation/intramolecular cyclization reaction between 2-trichloromethyl-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 2-trichloromethyl-4-chloropyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions.Conacy

Chemoselective Reduction of Trichloromethyl Compounds to <i>gem</i>-Dichloromethyl Groups Following Appel’s Reaction Protocol

A simple and easy reduction of trichloroacetyl compounds following the modification of Appel’s reaction protocol, using triphenylphosphine and methanol, afforded the corresponding dichloroacetyl compounds, with the exception of trichloro­acetyl­morpholine, in yields of 80–98% under very mild experimental conditions. Likewise, when trichloromethyl heterocyclic compounds contain another reactive functional group, the reaction is highly chemoselective giving the dichloromethyl derivative