ASCORBIC ACID AND THE FORMATION OF NITRIC OXIDE IN HUMAN LEUKOCYTES

Ascorbic acid is involved in the formation of nitrogen oxide in leukocytes of humans and animals. It is an important role of the AA in maintaining the immune status of the organism.Ascorbic acid is involved in the formation of nitrogen oxide in leukocytes of humans and animals. It is an important role of the AA in maintaining the immune status of the organism

Ascorbic Acid and the Formation of Nitric Oxide in Human Leukocytes

Ascorbic acid is involved in the formation of nitrogen oxide in leukocytes of humans and animals. It is an important role of the AA in maintaining the immune status of the organism

Antioxidant status and lipid peroxidation in stable coronary heart disease patients with dyslipidemia

Aim. To study lipid peroxidation (LP), pro-oxidant status, and antioxidant protection in coronary heart disease (CHD) patients with stable angina and post-infarction cardiosclerosis, who underwent coronaroangiography (CAG). Material and methods. The study included 32 CHD patients with Functional Class II-III angina, who underwent CAG, and 22 relatively healthy controls. Before CAG, plasma levels of lipids, PL products, uric acid, ceruloplasmin (CP), transferrin (RF) and methemoglobin (electron paramagnetic resonance), homocysteine (highly effective liquid chromatography), superoxide dismutase (SOD) and glutathione peroxidase (GP) in red blood cells were measured. Results. In CAG, severe coronary artery pathology was registered: occlusions of at least 70% comprised 63,7% of the total stenosis rate. Severe lipid metabolism and PL disturbances, as well as decrease in tissue and plasma antioxidant enzymes (SOD by 10%, GP by 46%, CP/TF by 33%) – were observed, comparing to the control group. There was a direct correlation between coronary artery stenosis rate and age (r=0,4) or levels of total cholesterol, low-density lipoprotein cholesterol (r=0,3), and PL product, MDA (r=0,34). Inverse correlation between stenosis number and antioxidant enzyme levels was also registered in CHD patients for SOD (r=-0,5), GP (r=-0,3), and CP/TF (r=-0,3). Conclusion. Coronary artery atherosclerosis severity was affected by tissue and plasma antioxidant enzyme levels, as well as by LP manifestation

Antioxidant effects of simvastatin in patients with coronary heart disease and dyslipidemia

Aim. To investigate the effects of simvastatin therapy on antioxidant enzyme activity and the correction of disturbed antioxidant status in patients with coronary heart disease (CHD) – post-infarction cardiosclerosis (PICS) – in combination with dyslipidemia (DLP). Material and methods. The study included 132 CHD patients with PICS and 20 healthy controls. All participants underwent the measurement of plasma levels of lipids, lipid peroxidation (LP) products – diene conjugates (DC) and 2-thiobarbituric acid reagents (TBAR), antioxidant enzymes – glutathione peroxidase (GP) and superoxide dismutase (SOD) in red blood cells, plasma activity of the antioxidant ceruloplasmin/transferrin system (AOS CP/TF) (electron paramagnetic resonance method), and 24-hour Holter monitoring of electrocardiogram (ECG). Results. The three-month simvastatin therapy (20 mg/day), as a component of the complex cardiac treatment, demonstrated its antioxidant effects and antiperoxidation activity in 60% of CHD patients. The subsequent therapy with 2-ethyl-6-methyl-3-hydroxypyridine sulphate (ES; 375 mg/day) and ubidecarenone (30 mg/ day) normalised the parameters of LP-antioxidant defence (AOD) and the levels of hepatic transaminases. Plasma AOS CP/TF activity inversely correlated with the duration of myocardial ischemia in CHD patients (r=-0,34; p=0,004). Conclusion. To optimise the treatment of atherogenic DLP in simvastatin-treated CHD patients, ubidecarenone and ES could be used to improve the LP-AOD parameters