Complete loss of case and gender within two generations: evidence from Stamford Hill Hasidic Yiddish

Yiddish was the everyday language spoken by most Central and East European Jews during the last millennium. As a result of the extreme loss of speakers during the Holocaust, subsequent geographic dispersal, and lack of institutional support, Yiddish is now an endangered language. Yet it continues to be a native and daily language for Haredi (strictly Orthodox) Jews, who live in close-knit communities worldwide. We have conducted the first study of the linguistic characteristics of the Yiddish spoken in the community in London’s Stamford Hill. While Krogh (in: Aptroot, Aptroot et al. (eds.) Leket: Yiddish studies today, Düsseldorf University Press, Düsseldorf, pp 483–506, 2012), Assouline (in: Aptroot, Hansen (eds.) Yiddish language structures, De Gruyter Mouton, Berlin, pp 39–62, 2014), and Sadock and Masor (J Jew Lang 6(1):89–110, 2018), investigating other Hasidic Yiddish-speaking communities, observe what they describe as morphological syncretism, in this paper we defend the claim that present-day Stamford Hill Hasidic Yiddish lacks morphological case and gender completely. We demonstrate that loss of morphological case and gender is the result of substantial language change over the course of two generations: while the case and gender system of the spoken medium was already beginning to undergo morphological syncretism and show some variation prior to World War II, case and gender distinctions were clearly present in the mental grammar of both Hasidic and non-Hasidic speakers of the relevant Yiddish dialects at that stage. We conclude the paper by identifying some of the language-internal, sociolinguistic and historical factors that have contributed to such rapid and pervasive language change, and compare the developments in Stamford Hill Hasidic Yiddish to those of minority German dialects in North America

Translating Covid-19 information into Yiddish for the UK Hasidic community

This article documents a recent project translating COVID-19 information into Yiddish for the benefit of the Hasidic Jewish communities in London’s Stamford Hill and in Manchester in the UK. The translation work developed as a response to the urgent need for Yiddish-language resources specifically designed for the Hasidic community near the beginning of the pandemic. The translations were undertaken by a team consisting of linguists and native speakers of Hasidic Yiddish and took place within the framework of a research project funded by the UK Arts and Humanities Research Council, dedicated to linguistic and sociolinguistic analysis of contemporary Hasidic Yiddish worldwide. In this article we discuss the sociolinguistic background to the translations and investigate the reasons why they were so urgently needed, before going on to address the issues encountered during the course of the translation process and the decisions taken in order to resolve them. These issues include the type of Yiddish chosen for the translations, the translation of medical terminology, gender-based linguistic differences affecting the translations, and specific cultural considerations that needed to be taken into account

Prognostic impact of reduced connexin43 expression and gap junction coupling of neoplastic stromal cells in giant cell tumor of bone

Missense mutations of the GJA1 gene encoding the gap junction channel protein connexin43 (Cx43) cause bone malformations resulting in oculodentodigital dysplasia (ODDD), while GJA1 null and ODDD mutant mice develop osteopenia. In this study we investigated Cx43 expression and channel functions in giant cell tumor of bone (GCTB), a locally aggressive osteolytic lesion with uncertain progression. Cx43 protein levels assessed by immunohistochemistry were correlated with GCTB cell types, clinico-radiological stages and progression free survival in tissue microarrays of 89 primary and 34 recurrent GCTB cases. Cx43 expression, phosphorylation, subcellular distribution and gap junction coupling was also investigated and compared between cultured neoplastic GCTB stromal cells and bone marow stromal cells or HDFa fibroblasts as a control. In GCTB tissues, most Cx43 was produced by CD163 negative neoplastic stromal cells and less by CD163 positive reactive monocytes/macrophages or by giant cells. Significantly less Cx43 was detected in alpha-smooth muscle actin positive than alpha-smooth muscle actin negative stromal cells and in osteoclast-rich tumor nests than in the adjacent reactive stroma. Progressively reduced Cx43 production in GCTB was significantly linked to advanced clinico-radiological stages and worse progression free survival. In neoplastic GCTB stromal cell cultures most Cx43 protein was localized in the paranuclear-Golgi region, while it was concentrated in the cell membranes both in bone marrow stromal cells and HDFa fibroblasts. In Western blots, alkaline phosphatase sensitive bands, linked to serine residues (Ser369, Ser372 or Ser373) detected in control cells, were missing in GCTB stromal cells. Defective cell membrane localization of Cx43 channels was in line with the significantly reduced transfer of the 622 Da fluorescing calcein dye between GCTB stromal cells. Our results show that significant downregulation of Cx43 expression and gap junction coupling in neoplastic stromal cells are associated with the clinical progression and worse prognosis in GCTB

Absence of morphological case and gender marking in Contemporary Hasidic Yiddish worldwide

This paper demonstrates that the language of the post-War generations of adult Haredi (i.e. strictly Orthodox), primarily Hasidic, speakers (18 to 87) of Yiddish in the major Hasidic centres worldwide lacks morphological case and gender. Elicited spoken and written data from native Haredi speakers of Yiddish from Israel and the United States, and limited additional evidence from Canada and Belgium reveals a complete absence of distinction between masculine, feminine, and neuter genders as well as between the nominative, accusative, and dative cases. While some speakers make use of a variety of morphological definite determiner and attributive adjective forms, their use is not determined by case or gender distinctions. These speakers have an invariable determiner pronounced as /dɛ/ or /di/, and the earlier case and gender suffixes on attributive adjectives have been reanalysed as a single attributive marker, /ɛ/. These findings are consistent with our previous work on the loss of case and gender in the Hasidic Yiddish of London’s Stamford Hill, and support our proposal that the Yiddish spoken in (primarily Hasidic) Haredi communities can be considered a distinct variety of the language known as Contemporary Hasidic Yiddis

The Loshn Koydesh Component in Contemporary Hasidic Yiddish

The loshn koydesh (Hebrew and Aramaic) component has historically influenced the development of Yiddish lexis and grammar. We examine its contemporary use among 26 native speakers of contemporary Hasidic Yiddish from Israel, New York, and London using a written questionnaire examining the gender of loshn koydesh nouns, periphrastic verbs with a Hebrew/Aramaic element, and adjectives derived from the loshn koydesh element of periphrastics. Our findings show that there are differences on both the geographical and gender axes, many of which are consistent with the speakers’ varied exposure to Modern Hebrew, English, and loshn koydesh. We also found that the loshn koydesh component has developed since the pre-War stage of the language in ways that seem to affect contemporary Hasidic Yiddish usage in all locations and for both genders. We take these developments to provide evidence for the existence of this newly emergent variety of Yiddish – Contemporary Hasidic Yiddish

Limb-saving surgery, survival, and prognostic factors for osteosarcoma: The Hungarian experience

info:eu-repo/semantics/publishe

Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone.

AIMS: Epidermal growth factor receptor (EGFR) is implicated in bone remodelling. The aim was to determine whether EGFR protein expression contributes to the aggressiveness and recurrence potential of giant cell tumour of bone (GCTB), an osteolytic primary bone tumour that can exhibit markedly variable clinical behaviour. METHODS AND RESULTS: Immunohistochemical analysis on tissue microarrays (TMA) of 231 primary, 97 recurrent, 17 metastatic and 26 malignant GCTBs was performed using TMA analysis software and whole digital slides allowing validated scoring. EGFR expression was restricted to neoplastic stromal cells and was significantly more frequent in recurrent (71 of 92; 77%) than in non-recurrent GCTBs (86 of 162; 53%) (P = 0.002); and in clinicoradiologically aggressive (31 of 43; 72%) than latent (27 of 54; 50%) cases (P = 0.034). Detecting phosphotyrosine epitopes pY1068 and -pY1173 indicated active EGFR signalling, and finding EGFR ligands EGF and transforming growth factor-α restricted to cells of the monocytic lineage suggested paracrine EGFR activation in stromal cells. In functional studies EGF supported proliferation of GCTB stromal cells, and the addition of EGF and macrophage-colony stimulating factor promoted osteoclastogenesis. CONCLUSION: In GCTB, EGFR signalling in neoplastic stromal cells may contribute to disease progression through promoting stromal cell proliferation and osteoclastogenesis