Inflation from Geometrical Tachyons

We propose an alternative formulation of tachyon inflation using the geometrical tachyon arising from the time dependent motion of a BPS $D3$-brane in the background geometry due to $k$ parallel $NS$5-branes arranged around a ring of radius $R$. Due to the fact that the mass of this geometrical tachyon field is $\sqrt{2/k}$ times smaller than the corresponding open-string tachyon mass, we find that the slow roll conditions for inflation and the number of e-foldings can be satisfied in a manner that is consistent with an effective 4-dimensional model and with a perturbative string coupling. We also show that the metric perturbations produced at the end of inflation can be sufficiently small and do not lead to the inconsistencies that plague the open string tachyon models. Finally we argue for the existence of a minimum of the geometrical tachyon potential which could give rise to a traditional reheating mechanism.Comment: Latex, 20 pages, 4 figures; correction of algebraic errors in section 5 concerning the tachyon potential near its minimum. Conclusions unchange

First-order melting of a weak spin-orbit Mott insulator into a correlated metal

The electronic phase diagram of the weak spin-orbit Mott insulator (Sr(1-x)Lax)3Ir2O7 is determined via an exhaustive experimental study. Upon doping electrons via La substitution, an immediate collapse in resistivity occurs along with a narrow regime of nanoscale phase separation comprised of antiferromagnetic, insulating regions and paramagnetic, metallic puddles persisting until x~0.04. Continued electron doping results in an abrupt, first-order phase boundary where the Neel state is suppressed and a homogenous, correlated, metallic state appears with an enhanced spin susceptibility and local moments. As the metallic state is stabilized, a weak structural distortion develops and suggests a competing instability with the parent spin-orbit Mott state.Comment: 5 pages, 4 figure

Loss of intranetwork and internetwork resting state functional connections with Alzheimer\u27s disease progression

Alzheimer\u27s disease (AD) is the most common cause of dementia. Much is known concerning AD pathophysiology but our understanding of the disease at the systems level remains incomplete. Previous AD research has used resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to assess the integrity of functional networks within the brain. Most studies have focused on the default-mode network (DMN), a primary locus of AD pathology. However, other brain regions are inevitably affected with disease progression. We studied rs-fcMRI in five functionally defined brain networks within a large cohort of human participants of either gender (n = 510) that ranged in AD severity from unaffected [clinical dementia rating (CDR) 0] to very mild (CDR 0.5) to mild (CDR 1). We observed loss of correlations within not only the DMN but other networks at CDR 0.5. Within the salience network (SAL), increases were seen between CDR 0 and CDR 0.5. However, at CDR 1, all networks, including SAL, exhibited reduced correlations. Specific networks were preferentially affected at certain CDR stages. In addition, cross-network relations were consistently lost with increasing AD severity. Our results demonstrate that AD is associated with widespread loss of both intranetwork and internetwork correlations. These results provide insight into AD pathophysiology and reinforce an integrative view of the brain\u27s functional organization

Spatially resolved spectroscopy of the globular cluster RZ 2109 and the nature of its black hole

We present optical HST/STIS spectroscopy of RZ 2109, a globular cluster in the elliptical galaxy NGC 4472. This globular cluster is notable for hosting an ultraluminous X-ray source as well as associated strong and broad [OIII] 4959, 5007 emission. We show that the HST/STIS spectroscopy spatially resolves the [OIII] emission in RZ 2109. While we are unable to make a precise determination of the morphology of the emission line nebula, the best fitting models all require that the [OIII] 5007 emission has a half light radius in the range 3-7 pc. The extended nature of the [OIII] 5007 emission is inconsistent with published models that invoke an intermediate mass black hole origin. It is also inconsistent with the ionization of ejecta from a nova in the cluster. The spatial scale of the nebula could be produced via the photoionization of a strong wind driven from a stellar mass black hole accreting at roughly its Eddington rate.Comment: 7 pages, 4 figures - accepted for publication in Ap

Early-season insect defoliation influences the critical time for weed removal in soybean

To develop more effective pest-management strategies, it is essential to understand how different pests interact with each other and the crop. Field studies were conducted in 2003 and 2004 at two Nebraska locations to determine the effects of early-season crop defoliation on the critical time for weed removal (CTWR) in narrow-row soybean. Three soybean defoliation levels were selected to simulate 0, 30, and 60% leaf tissue removal by the bean leaf beetle. Weeds were allowed to compete with the crop until V2, V4, V6, R3, and R5 growth stages. There were also season-long weedy and weed-free treatments. Results indicated that the CTWR in soybean occurred earlier as defoliation levels increased from 0 to 60%. The CTWR occurred at V3, V2, and V1 growth stage for 0, 30, and 60% defoliation levels, respectively. Overall, 60% defoliation resulted in earlier CTWR by at least 14 d. Yield losses from defoliation and weed interference were primarily associated with a reduction in number of pods per plant-1

Ectopy on a single 12‐lead ECG, incident cardiac myopathy, and death in the community

BackgroundAtrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12-lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12-lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality.Methods and resultsWe utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort. The ARIC (Atherosclerosis Risk in Communities Study), the replication cohort, captured data from 15 792 participants over a median of 22 years. In the CHS, multivariable analyses revealed that a baseline 12-lead ECG premature atrial contraction predicted a 60% increased risk of atrial fibrillation (hazard ratio, 1.6; 95% CI, 1.3-2.0; P<0.001) and a premature ventricular contraction predicted a 30% increased risk of heart failure (hazard ratio, 1.3; 95% CI, 1.0-1.6; P=0.021). In the negative control analyses, neither predicted incident myocardial infarction. A premature atrial contraction was associated with a 30% increased risk of death (hazard ratio, 1.3; 95% CI, 1.1-1.5; P=0.008) and a premature ventricular contraction was associated with a 20% increased risk of death (hazard ratio, 1.2; 95% CI, 1.0-1.3; P=0.044). Similarly statistically significant results for each analysis were also observed in ARIC.ConclusionsBased on a single standard ECG, a premature atrial contraction predicted incident atrial fibrillation and death and a premature ventricular contraction predicted incident heart failure and death, suggesting that this commonly used test may predict future disease

Risk factors for brain health in agricultural work: a systematic review

Includes bibliographical references.Certain exposures related to agricultural work have been associated with neurological disorders. To date, few studies have included brain health measurements to link specific risk factors with possible neural mechanisms. Moreover, a synthesis of agricultural risk factors associated with poorer brain health outcomes is missing. In this systematic review, we identified 106 articles using keywords related to agriculture, occupational exposure, and the brain. We identified seven major risk factors: non-specific factors that are associated with agricultural work itself, toluene, pesticides, heavy metal or dust exposure, work with farm animals, and nicotine exposure from plants. Of these, pesticides are the most highly studied. The majority of qualifying studies were epidemiological studies. Nigral striatal regions were the most well studied brain area impacted. Of the three human neuroimaging studies we found, two focused on functional networks and the third focused on gray matter. We identified two major directions for future studies that will help inform preventative strategies for brain health in vulnerable agricultural workers: (1) the effects of moderators such as type of work, sex, migrant status, race, and age; and (2) more comprehensive brain imaging studies, both observational and experimental, involving several imaging techniques

Geometrical Tachyon Kinks and NS5 Branes

We further investigate the $NS$5 ring background using the tachyon map. Mapping the radion fields to the rolling tachyon helps to explain the motion of a probe $Dp$-brane in this background. It turns out that the radion field becomes tachyonic when the brane is confined to one dimensional motion inside the ring. We find explicit solutions for the geometrical tachyon field that describe stable kink solutions which are similar to those of the open string tachyon. Interestingly in the case of the geometric tachyon, the dynamics is controlled by a cosine potential. In addition, we couple a constant electric field to the probe-brane, but find that the only stable kink solutions occur when there is zero electric field or a critical field value. We also investigate the behaviour of Non-BPS branes in this background, and find that the end state of any probe brane is that of tachyonic matter 'trapped' around the interior of the ring. We conclude by considering compactification of the ring solution in one of the transverse directions.Comment: Latex, 24 pages, 1 eps fig; clarifying comments added to Section 2; typos correcte

Review and Evaluation of Hand–Arm Coordinate Systems for Measuring Vibration Exposure, Biodynamic Responses, and Hand Forces

AbstractThe hand coordinate systems for measuring vibration exposures and biodynamic responses have been standardized, but they are not actually used in many studies. This contradicts the purpose of the standardization. The objectives of this study were to identify the major sources of this problem, and to help define or identify better coordinate systems for the standardization. This study systematically reviewed the principles and definition methods, and evaluated typical hand coordinate systems. This study confirms that, as accelerometers remain the major technology for vibration measurement, it is reasonable to standardize two types of coordinate systems: a tool-based basicentric (BC) system and an anatomically based biodynamic (BD) system. However, these coordinate systems are not well defined in the current standard. Definition of the standard BC system is confusing, and it can be interpreted differently; as a result, it has been inconsistently applied in various standards and studies. The standard hand BD system is defined using the orientation of the third metacarpal bone. It is neither convenient nor defined based on important biological or biodynamic features. This explains why it is rarely used in practice. To resolve these inconsistencies and deficiencies, we proposed a revised method for defining the realistic handle BC system and an alternative method for defining the hand BD system. A fingertip-based BD system for measuring the principal grip force is also proposed based on an important feature of the grip force confirmed in this study