7,242 research outputs found

    Feedback Control of Nuclear Spin Bath of a Single Hole Spin in a Quantum Dot

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    Experiment study on the effect of iron ore sinter behavior with adding biomass

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    This paper focused on the effect of sinter behavior with biomass.The changes of the relevant performance indexes of this sinter behavior, emission laws of harmful gases in flue gas emissions and the mechanism of emission reduction was studied in this paper.The results showed that, when the biomass amount is 0,28 %, the sinter index can meet production requirement, the porosity of sinter increased by 18,5 %, the sinter reduction degree increased by 2,66 %, the SO2 emissions of harmful gases in the flue gas reduced by about 14 %, the amount of NOx about 19 % lower

    Online Station Assignment for Electric Vehicle Battery Swapping

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    This paper investigates the online station assignment for (commercial) electric vehicles (EVs) that request battery swapping from a central operator, i.e., in the absence of future information a battery swapping service station has to be assigned instantly to each EV upon its request. Based on EVs' locations, the availability of fully-charged batteries at service stations in the system, as well as traffic conditions, the assignment aims to minimize cost to EVs and congestion at service stations. Inspired by a polynomial-time offline solution via a bipartite matching approach, we develop an efficient and implementable online station assignment algorithm that provably achieves the tight (optimal) competitive ratio under mild conditions. Monte Carlo experiments on a real transportation network by Baidu Maps show that our algorithm performs reasonably well on realistic inputs, even with a certain amount of estimation error in parameters

    Online Station Assignment for Electric Vehicle Battery Swapping

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    This paper investigates the online station assignment for (commercial) electric vehicles (EVs) that request battery swapping from a central operator, i.e., in the absence of future information a battery swapping service station has to be assigned instantly to each EV upon its request. Based on EVs' locations, the availability of fully-charged batteries at service stations in the system, as well as traffic conditions, the assignment aims to minimize cost to EVs and congestion at service stations. Inspired by a polynomial-time offline solution via a bipartite matching approach, we develop an efficient and implementable online station assignment algorithm that provably achieves the tight (optimal) competitive ratio under mild conditions. Monte Carlo experiments on a real transportation network by Baidu Maps show that our algorithm performs reasonably well on realistic inputs, even with a certain amount of estimation error in parameters

    Evidence for local aldosterone synthesis in the large intestine of the mouse

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    Aldosterone, the main physiological mineralocorticoid, regulates sodium and potassium balance in the distal convoluted tubule of the kidney. Aldosterone is synthesized from cholesterol in the adrenal cortex in a sequence of enzymatic steps. Recently however, several tissues or cells e.g. brain, heart, blood vessels, kidneys and adipocytes have been shown to possess capability to produce aldosterone locally, and there is some evidence that this occurs also in the intestine. Colon expresses mineralocorticoid receptors and is capable of synthesizing corticosterone, the second last intermediate on the route to aldosterone from cholesterol. Based on such reports and on our preliminary finding, we hypothesized that aldosterone could be synthesized locally in the intestine and therefore we measured the concentration of aldosterone as well as the protein and gene expression of aldosterone synthase (CYP11B2), an enzyme responsible on aldosterone synthesis, from the distal section of the gastrointestinal tract of 10-week-old Balb/c male mice. It is known that sodium deficiency regulates aldosterone synthesis in adrenal glands, therefore we fed the mice with low (0.01%), normal (0.2%) and high-sodium (1.6%) diets for 14 days. Here we report that, aldosterone was detected in colon and cecum samples. Measurable amounts of CYP11B2 protein were detected by Western blot and Elisa analysis from both intestinal tissues. We detected CYP1182 gene expression from the large intestine along with immunohistochemical findings of CYP11B2 in colonic wall. Sodium depletion increased the aldosterone concentration in plasma compared to control and high-sodium groups as well as in the intestine compared to mice fed with the high-sodium diet. To summarize, this study further supports the presence of aldosterone and the enzyme needed to produce this mineralocorticoid in the murine large intestine.Peer reviewe

    Etanercept Inhibits Pro-inflammatory Cytokines Expression in Titanium Particle-Stimulated Peritoneal Macrophages

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    Purpose: To investigate the inhibitory role of Etanercept in pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6 production in titanium (Ti) particle stimulated macrophages.Methods: Peritoneal macrophages were stimulated with 1 × 109 Ti particles and treated simultaneously with or without 10, 100, or 1000 ng/mL Etanercept. The levels of TNF-α, IL-1β and IL-6 in the culture supernatants were measured using ELISA.Results: Titanium particles could stimulate TNF-α, IL-1β and IL-6 secretion in peritoneal macrophages. Etanercept inhibited Ti particle-induced TNF-α release by 29.7 % at 10 ng/ml (19.19 ± 4.72 pg/mL, p < 0.01), 49.3 % at 100 ng/mL (13.83 ± 3.72 pg/ml, p < 0.01) and 60.4 % at 1000 ng/mL (10.82 ± 3.87 pg/mL, p < 0.001), IL-1β release by 5.23 % at 10 ng/mL (34.79 ± 7.83 pg/mL, p > 0.05), 21.06 % at 100 ng/mL (28.98 ± 4.81 pg/mL, p < 0.01) and 29.83 % at 1000 ng/mL (25.76 ± 5.23 pg/ml, p < 0.001), and IL-6 release by 38.69 % at 10 ng/mL (256.8 ± 99.56 pg/mL, p < 0.01), by 42.13 % at 100 ng/mL (242.4 ± 33.26 pg/mL, p < 0.01) and 53.4 % at 1000 ng/ml (195.2 ± 48.82 pg/mL, p < 0.001).Conclusion: Etanercept has potent ability to prevent wear debris–induced osteolysis and may be valuable as a therapeutic agent for the treatment of prosthetic loosening in humans.Keywords: Etanercept; titanium particle; proinflammatory cytokines; peritoneal macrophage
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