PRIMARY HYPERPARATHYROIDISM AT THE BACKGROUND OF PARATHYROID GLAND HYPERPLASIA. PECULIARITIES AND DIFFICULTIES OF DIAGNOSTICS

The article uses a clinical case of primary hyperparathyroidism in young patient with hyperplastic parathyroid gland localization in tissues of thyroid gland as an example to study the matters of cytological, histological, clinical and laboratory diagnostics of such pathology. It provides a literature reference on the difficulties of establishing a cytological and histological diagnoses, sets out the peculiarities of morphological pattern, discusses the tactical matters of primary hyperparathyroidism management, indications for surgical treatment and case follow-up of patients

A Copper-Nitroxide Adduct Exhibiting Separate Single Crystal-to-Single Crystal Polymerization-Depolymerization and Spin Crossover Transitions

© 2016 American Chemical Society.A complex cascade of solid-state processes initiated by variation of temperature was found for the heterospin complex [Cu(hfac)2LMe/Et] formed in the reaction of copper(II) hexafluoroacetylacetonate [Cu(hfac)2] with stable nitronyl nitroxide 2-(1-methyl-3-ethyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (LMe/Et). The cooling of the compound below 260 K initiated a solid-state chemical reaction, which led to a depolymerization of chains and formation of a pair heterospin complex [Cu(hfac)2LMe/Et2][[Cu(hfac)2]3LMe/Et2]. Further decrease in temperature below 144 K led to a spin transition accompanied by a drastic decrease in the effective magnetic moment from 2.52 to 2.24 μB. When the compound was heated, the order of effects was reversed: at first, the magnetic moment abruptly increased, and then the molecular fragments of the pair cluster united into polymer chains. Two hysteresis loops correspond to this cascade of temperature-induced structural transformations on the experimental dependence μeff(T): one at high (T ' = 283 K and T " = 260 K) and the other at low (T= 161 K, T = 144 K) temperature. The spin transitions were also recorded for the [[Cu(hfac)2]3LBu/Et2] and [[Cu(hfac)2]5LBu/Et4] molecular complexes, which are models of the trinuclear fragment of the {[Cu(hfac)2]3LMe/Et2} pair cluster

The use of Kuraderm drug in the treatment of basal cell carcinoma of the head and neck

Basal cell carcinoma is one of the most common malignancies. Despite a wide range of treatment options and relatively good prognosis of the disease, there may be restrictions on the use of standard methods of treatment because of elderly patients, their physical condition and characteristics of the tumor localization. We provide clinical examples of successful treatment of basal cell carcinoma of the head and neck with Kuraderm BEC5. This is a drug with anti-tumor activity for topical use made on the basis of glycoalkaloids of plants of nightshade family

MEDULLARY THYROID CANCER AS PART OF MEN 2B SYNDROME. CASE REPORT

MEN 2B syndrome is a subtype of the multiple endocrine neoplasia type 2. It is characterized by the development of aggressive forms of medullary thyroid cancer at an early age, pheochromocytoma and hyperparathyroid syndrome. This article provides an own clinical observation of the patient with MEN 2B syndrome associated with a mutation in the proto-oncogene RET

Crystal structure and Hirshfeld surface analysis of 2-amino-4-(4-methoxyphenyl)-6-oxo-1-phenyl-1,4,5,6-tetrahydropyridine-3-carbonitrile

The central tetrahydropyridine ring of the title compound, C19H17N3O2, adopts a screw-boat conformation. In the crystal, strong C-H center dot center dot center dot O and N-H center dot center dot center dot N hydrogen bonds form dimers with R-2(2)(14) and R-2(2)(12) ring motifs, respectively, between consecutive molecules along the c-axis direction. Intermolecular N-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds connect these dimers, forming a three-dimensional network. C-H center dot center dot center dot pi interactions and pi-pi stacking interactions contribute to the stabilization of the molecular packing. A Hirshfeld surface analysis indicates that the contributions from the most prevalent interactions are H center dot center dot center dot H (47.1%), C center dot center dot center dot H/H center dot center dot center dot C (20.9%), O center dot center dot center dot H/H center dot center dot center dot O (15.3%) and N center dot center dot center dot H/H center dot center dot center dot N (11.4%)

Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report

The study objective is to report a case of successful treatment of disseminated nasopharyngeal carcinoma with nivolumab.Materials and methods. A 22-year-old male patient was admitted to N.N. Blokhin National Medical Research Center of Oncology with a diagnosis of T3N3M1 stage IV nasopharyngeal carcinoma with bone metastasis. After a course of radical chemoradiotherapy, the patient was found to have cancer progression. Between September 2016 and July 2017, the patient received chemotherapy with 3 lines of drugs, but with no effect. We decided to initiate treatment with PD-1 inhibitors. The patient received nivolumab 3 mg/kg every 2 weeks between July 2017 and March 2018.Results. Positron emission tomography (September 2018) demonstrated no increased uptake of [18F]-fluorodeoxyglucose in earlier identified cancer foci. Since September 2018, the patient has been in persistent remission without any therapy.Conclusion. This case report demonstrates high efficacy of PD-1 inhibitors in the treatment of disseminated recurrent nasopharyngeal squamous cell carcinoma, resistant to standard radiotherapy and chemotherapy

Organ preservation treatment of locally advanced cancer of the laryngopharynx using regional intra-arterial chemotherapy in a patient with solitary kidney

Introduction. Chemoradiation therapy with a competitive regimen allows to avoid laryngectomy and increase patients’ quality of life. However, it’s highly toxic and this limits the use of this approach in patients with severe concomitant disorders. The alternative to systemic chemotherapy is infusion of high doses of chemotherapy drugs directly into a vessel supplying the tumor through a microcatheter.The study objective is to present a clinical case of using intra-arterial chemotherapy for treatment of locally advanced laryngopharyngeal cancer in a patient with a solitary functioning kidney. Materials and methods. Patient K., 55 years old, applied to the Head and Neck Tumors Clinical of the N.N.  Blokhin National Medical Research Center of Oncology with laryngopharyngeal cancer and bilateral metastases in the lymph nodes (T3N2M0,  stage IV). Use of systemic chemotherapy for this patient was limited because he had only 1 functional kidney. Three (3) courses of intra-arterial chemotherapy with docetaxel and cisplatin 60 mg/m2 (with detoxification with sodium thiosulfate) and subsequent radiation therapy, systemic infusion of 5-fluorouracil were performed.Results. The main side effect of the treatment was edema of the pharyngeal and laryngeal mucosa but without severe respiratory distress. The symptoms were corrected with inhalations of oxygen-hydrocortisone mixture. Laboratory and instrumental control during treatment didn’t show any deterioration of the state of the solitary functioning kidney.Conclusion. Regional intra-arterial chemotherapy demonstrated a satisfactory effect in a patient with severe concomitant pathology and absolute counterindications for systemic chemotherapy

A Copper-Nitroxide Adduct Exhibiting Separate Single Crystal-to-Single Crystal Polymerization-Depolymerization and Spin Crossover Transitions

© 2016 American Chemical Society.A complex cascade of solid-state processes initiated by variation of temperature was found for the heterospin complex [Cu(hfac)2LMe/Et] formed in the reaction of copper(II) hexafluoroacetylacetonate [Cu(hfac)2] with stable nitronyl nitroxide 2-(1-methyl-3-ethyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (LMe/Et). The cooling of the compound below 260 K initiated a solid-state chemical reaction, which led to a depolymerization of chains and formation of a pair heterospin complex [Cu(hfac)2LMe/Et2][[Cu(hfac)2]3LMe/Et2]. Further decrease in temperature below 144 K led to a spin transition accompanied by a drastic decrease in the effective magnetic moment from 2.52 to 2.24 μB. When the compound was heated, the order of effects was reversed: at first, the magnetic moment abruptly increased, and then the molecular fragments of the pair cluster united into polymer chains. Two hysteresis loops correspond to this cascade of temperature-induced structural transformations on the experimental dependence μeff(T): one at high (T ' = 283 K and T " = 260 K) and the other at low (T= 161 K, T = 144 K) temperature. The spin transitions were also recorded for the [[Cu(hfac)2]3LBu/Et2] and [[Cu(hfac)2]5LBu/Et4] molecular complexes, which are models of the trinuclear fragment of the {[Cu(hfac)2]3LMe/Et2} pair cluster

A Copper-Nitroxide Adduct Exhibiting Separate Single Crystal-to-Single Crystal Polymerization-Depolymerization and Spin Crossover Transitions

© 2016 American Chemical Society.A complex cascade of solid-state processes initiated by variation of temperature was found for the heterospin complex [Cu(hfac)2LMe/Et] formed in the reaction of copper(II) hexafluoroacetylacetonate [Cu(hfac)2] with stable nitronyl nitroxide 2-(1-methyl-3-ethyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (LMe/Et). The cooling of the compound below 260 K initiated a solid-state chemical reaction, which led to a depolymerization of chains and formation of a pair heterospin complex [Cu(hfac)2LMe/Et2][[Cu(hfac)2]3LMe/Et2]. Further decrease in temperature below 144 K led to a spin transition accompanied by a drastic decrease in the effective magnetic moment from 2.52 to 2.24 μB. When the compound was heated, the order of effects was reversed: at first, the magnetic moment abruptly increased, and then the molecular fragments of the pair cluster united into polymer chains. Two hysteresis loops correspond to this cascade of temperature-induced structural transformations on the experimental dependence μeff(T): one at high (T ' = 283 K and T " = 260 K) and the other at low (T= 161 K, T = 144 K) temperature. The spin transitions were also recorded for the [[Cu(hfac)2]3LBu/Et2] and [[Cu(hfac)2]5LBu/Et4] molecular complexes, which are models of the trinuclear fragment of the {[Cu(hfac)2]3LMe/Et2} pair cluster

A Copper-Nitroxide Adduct Exhibiting Separate Single Crystal-to-Single Crystal Polymerization-Depolymerization and Spin Crossover Transitions

© 2016 American Chemical Society.A complex cascade of solid-state processes initiated by variation of temperature was found for the heterospin complex [Cu(hfac)2LMe/Et] formed in the reaction of copper(II) hexafluoroacetylacetonate [Cu(hfac)2] with stable nitronyl nitroxide 2-(1-methyl-3-ethyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (LMe/Et). The cooling of the compound below 260 K initiated a solid-state chemical reaction, which led to a depolymerization of chains and formation of a pair heterospin complex [Cu(hfac)2LMe/Et2][[Cu(hfac)2]3LMe/Et2]. Further decrease in temperature below 144 K led to a spin transition accompanied by a drastic decrease in the effective magnetic moment from 2.52 to 2.24 μB. When the compound was heated, the order of effects was reversed: at first, the magnetic moment abruptly increased, and then the molecular fragments of the pair cluster united into polymer chains. Two hysteresis loops correspond to this cascade of temperature-induced structural transformations on the experimental dependence μeff(T): one at high (T ' = 283 K and T " = 260 K) and the other at low (T= 161 K, T = 144 K) temperature. The spin transitions were also recorded for the [[Cu(hfac)2]3LBu/Et2] and [[Cu(hfac)2]5LBu/Et4] molecular complexes, which are models of the trinuclear fragment of the {[Cu(hfac)2]3LMe/Et2} pair cluster