12,046 research outputs found
The wall effect in cavity flow
A non-linear theory for the calculation of the flow field of an oblique flat plate under blockage condition is given using the techniques of integral equations. Numerical results are obtained with the aid of a high speed digital computer for the plate situated mid-channel at values of the angle of attack from 50 to 90° and the channel width-chord ratio from 3 to 20. Also obtained are results for the plate situated at two different off-center positions for a channel width-chord ratio 5 and angles of attack less than 30°
A Computer Method for Calculation of the Complete and Incomplete Elliptic Integrals of the Third Kind
Numerical approximations and a Fortran IV program are given
for the calculation by an IBM 7090 computer of the complete and incomplete elliptic integrals of the third kind. In its present form results are limited to six decimal places, but the method is valid for all values of amplitude φ, modulus k and real values of the parameter a^2. For
the purpose of completeness, adaptations of other programs for complete and incomplete elliptic integrals of the first and second kind are also presented
Strategy evaluation and optimization with an artificial society toward a Pareto optimum
Strategy evaluation and optimization in response to troubling urban issues has become a challenging issue due to increasing social uncertainty, unreliable predictions, and poor decision-making. To address this problem, we propose a universal computational experiment framework with a fine-grained artificial society that is integrated with data-based models. The purpose of the framework is to evaluate the consequences of various combinations of strategies geared towards reaching a Pareto optimum with regards to efficacy versus costs. As an example, by modeling coronavirus 2019 mitigation, we show that Pareto frontier nations could achieve better economic growth and more effective epidemic control through the analysis of real-world data. Our work suggests that a nation’s intervention strategy could be optimized based on the measures adopted by Pareto frontier nations through large-scale computational experiments. Our solution has been validated for epidemic control, and it can be generalized to other urban issues as well
Linearized Theory of a Two-Dimensional Planing Flat Plate in a Channel of Finite Depth - I
Linearized free-streamline theory is used to calculate the spray-sheet thickness and lift-slope for a flat plate, cavitating, two-dimensional hydrofoil in a channel of finite depth with an upper free surface and lower
boundary partly free and partly rigid. Only the case of zero cavitation number is considered. Some measurements were made of the submergence of a hydrofoil of four inches chord beneath the undisturbed free surface at
velocities of 12 and 18ft./sec. These agree with the trends of the theory but not with the magnitudes, the submergence always being greater than that predicted by the theory
Identification of α°-thalassaemia (–SEA) using an enzyme-linked immunosorbent assay (ELISA) for embryonic zeta-globin chain detection – a preliminary study
Objectives: This study aimed to evaluate the UBI MAGIWELTM ζ-GLOBIN ELISA Kit for the presumptive diagnosis of αo-thalassaemia. The ELISA results obtained were confirmed by molecular characterisation of αo-thalassaemia using a Duplex-PCR. Methods: Routine peripheral blood counts and red cell indices were determined in 94 blood samples sent for Hb analysis. Hb subtypes were quantified by high performance liquid chromatography (HPLC) and Hb electrophoresis conducted on agarose gel at pH 8.5. Zeta-globin chain levels were determined using the UBI MAGIWELTM ζ-GLOBIN ELISA Kit. Molecular analysis was performed using a duplex-PCR which simultaneously amplifies a normal 136 bp sequence between the ψα−α2-globin genes and a 730 bp Southeast Asian deletion-specific sequence (–SEA) between the ψα2−θ1-globin genes. Results: Using the ELISA assay kit, 20 blood samples were presumptively identified as α-thalassaemia carriers from elevated ζ-globin chains (OD>0.3) while the remaining 74 blood samples showed OD<0.3. Molecular characterisation confirmed amplification of the 136 bp normal fragment in all the blood samples. Seventeen of the 20 DNA samples from the α-thalassaemia carriers amplified the SEA-deletion specific fragment. The remaining three DNA samples did not amplify the SEA-deletion specific fragment but amplified the normal α-globin gene sequence, indicating the presence of amplifiable DNA in these samples. Further molecular characterisation of the α-3.7 and -α4.2 deletions and Hb Constant Spring (CS) mutation showed the absence of these defects in these 3 DNA samples. Conclusion: This preliminary investigation showed the sensitivity and specificity of the UBI MAGIWEL ζ-globin ELISA kit as 100 % and 96.1 % respectively in the detection of α-thalassaemia-1 carriers (–SEA)
Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma.
Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, and thus may mediate oncogenic or tumor suppressing effects, as well as be a new class of cancer therapeutic targets. We performed high-throughput sequencing of RNA (RNA-seq) to investigate the expression level of lncRNAs and protein-coding genes in 30 esophageal samples, comprised of 15 esophageal squamous cell carcinoma (ESCC) samples and their 15 paired non-tumor tissues. We further developed an integrative bioinformatics method, denoted URW-LPE, to identify key functional lncRNAs that regulate expression of downstream protein-coding genes in ESCC. A number of known onco-lncRNA and many putative novel ones were effectively identified by URW-LPE. Importantly, we identified lncRNA625 as a novel regulator of ESCC cell proliferation, invasion and migration. ESCC patients with high lncRNA625 expression had significantly shorter survival time than those with low expression. LncRNA625 also showed specific prognostic value for patients with metastatic ESCC. Finally, we identified E1A-binding protein p300 (EP300) as a downstream executor of lncRNA625-induced transcriptional responses. These findings establish a catalog of novel cancer-associated functional lncRNAs, which will promote our understanding of lncRNA-mediated regulation in this malignancy
Factorization Properties of Soft Graviton Amplitudes
We apply recently developed path integral resummation methods to perturbative
quantum gravity. In particular, we provide supporting evidence that eikonal
graviton amplitudes factorize into hard and soft parts, and confirm a recent
hypothesis that soft gravitons are modelled by vacuum expectation values of
products of certain Wilson line operators, which differ for massless and
massive particles. We also investigate terms which break this factorization,
and find that they are subleading with respect to the eikonal amplitude. The
results may help in understanding the connections between gravity and gauge
theories in more detail, as well as in studying gravitational radiation beyond
the eikonal approximation.Comment: 35 pages, 5 figure
Charge superconductivity from pair density wave order in certain high temperature superconductors
A number of spectacular experimental anomalies\cite{li-2007,fujita-2005} have
recently been discovered in certain cuprates, notably {\LBCO} and {\LNSCO},
which exhibit unidirectional spin and charge order (known as ``stripe order'').
We have recently proposed to interpret these observations as evidence for a
novel ``striped superconducting'' state, in which the superconducting order
parameter is modulated in space, such that its average is precisely zero. Here,
we show that thermal melting of the striped superconducting state can lead to a
number of unusual phases, of which the most novel is a charge
superconducting state, with a corresponding fractional flux quantum .
These are never-before observed states of matter, and ones, moreover, that
cannot arise from the conventional Bardeen-Cooper-Schrieffer (BCS) mechanism.
Thus, direct confirmation of their existence, even in a small subset of the
cuprates, could have much broader implications for our understanding of high
temperature superconductivity. We propose experiments to observe fractional
flux quantization, which thereby could confirm the existence of these states.Comment: 5 pages, 2 figures; new version in Nature Physics format with a
discussion of the effective Josephson coupling J2 and minor changes. Mildly
edited abstract. v3: corrected versio
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