Relative Permeability of Homogenous-Wet and Mixed-Wet Porous Media as Determined by Pore-Scale Lattice Boltzmann Modeling

We present a pore-scale study of two-phase relative permeability in homogenous-wet porous media, and porous media altered to a mixed-wet state. A Shan-Chen type multicomponent lattice Boltzmann (LB) model is employed to determine pore-scale fluid distributions and relative permeability. Mixed-wet states are created by altering the wettability of solid surfaces in contact with the nonwetting phase at the end of steady state simulation of initially homogenous-wet porous media. To ensure accurate representation of fluid-solid interfacial areas, we compare LB simulation results to experimental measurements of interfacial fluid-fluid and fluid-solid areas determined by X-ray computed microtomography imaging of water and oil distributions in bead packs. The LB simulations are found to match experimental trends observed for fluid-fluid and fluid-solid interfacial area-saturation relationships. The relative permeability of both fluids in the homogenous-wet porous media was found to decrease with a decreasing contact angle. The relative permeability of both fluids in the altered, mixed-wet porous media was found to decrease for all mixed-wet states in comparison to the initial homogenous-wet states. The nonwetting phase relative permeability decreased significantly, while the wetting phase experienced only a minor decrease. The significance of the decrease was found to be dependent on the distribution of the unaltered solid surfaces, with less dependence on the severity of alteration. Key Points Lattice Boltzmann simulation interfacial areas match experimental trends Wetting phase relative permeability is unaffected by wettability alteration Nonwetting phase relative permeability is decreased by wettability alteration © 2014. American Geophysical Union

Velocity profile of granular flows inside silos and hoppers

We measure the flow of granular materials inside a quasi-two dimensional silo as it drains and compare the data with some existing models. The particles inside the silo are imaged and tracked with unprecedented resolution in both space and time to obtain their velocity and diffusion properties. The data obtained by varying the orifice width and the hopper angle allows us to thoroughly test models of gravity driven flows inside these geometries. All of our measured velocity profiles are smooth and free of the shock-like discontinuities ("rupture zones") predicted by critical state soil mechanics. On the other hand, we find that the simple Kinematic Model accurately captures the mean velocity profile near the orifice, although it fails to describe the rapid transition to plug flow far away from the orifice. The measured diffusion length $b$, the only free parameter in the model, is not constant as usually assumed, but increases with both the height above the orifice and the angle of the hopper. We discuss improvements to the model to account for the differences. From our data, we also directly measure the diffusion of the particles and find it to be significantly less than predicted by the Void Model, which provides the classical microscopic derivation of the Kinematic Model in terms of diffusing voids in the packing. However, the experimental data is consistent with the recently proposed Spot Model, based on a simple mechanism for cooperative diffusion. Finally, we discuss the flow rate as a function of the orifice width and hopper angles. We find that the flow rate scales with the orifice size to the power of 1.5, consistent with dimensional analysis. Interestingly, the flow rate increases when the funnel angle is increased.Comment: 17 pages, 8 figure

Analysis of Granular Flow in a Pebble-Bed Nuclear Reactor

Pebble-bed nuclear reactor technology, which is currently being revived around the world, raises fundamental questions about dense granular flow in silos. A typical reactor core is composed of graphite fuel pebbles, which drain very slowly in a continuous refueling process. Pebble flow is poorly understood and not easily accessible to experiments, and yet it has a major impact on reactor physics. To address this problem, we perform full-scale, discrete-element simulations in realistic geometries, with up to 440,000 frictional, viscoelastic 6cm-diameter spheres draining in a cylindrical vessel of diameter 3.5m and height 10m with bottom funnels angled at 30 degrees or 60 degrees. We also simulate a bidisperse core with a dynamic central column of smaller graphite moderator pebbles and show that little mixing occurs down to a 1:2 diameter ratio. We analyze the mean velocity, diffusion and mixing, local ordering and porosity (from Voronoi volumes), the residence-time distribution, and the effects of wall friction and discuss implications for reactor design and the basic physics of granular flow.Comment: 18 pages, 21 figure

Benefits of Artificially Generated Gravity Gradients for Interferometric Gravitational-Wave Detectors

We present an approach to experimentally evaluate gravity gradient noise, a potentially limiting noise source in advanced interferometric gravitational wave (GW) detectors. In addition, the method can be used to provide sub-percent calibration in phase and amplitude of modern interferometric GW detectors. Knowledge of calibration to such certainties shall enhance the scientific output of the instruments in case of an eventual detection of GWs. The method relies on a rotating symmetrical two-body mass, a Dynamic gravity Field Generator (DFG). The placement of the DFG in the proximity of one of the interferometer's suspended test masses generates a change in the local gravitational field detectable with current interferometric GW detectors.Comment: 16 pages, 4 figure

Metrics for Operator Situation Awareness, Workload, and Performance in Automated Separation Assurance Systems

A research consortium of scientists and engineers from California State University Long Beach (CSULB), San Jose State University Foundation (SJSUF), California State University Northridge (CSUN), Purdue University, and The Boeing Company was assembled to evaluate the impact of changes in roles and responsibilities and new automated technologies, being introduced in the Next Generation Air Transportation System (NextGen), on operator situation awareness (SA) and workload. To meet these goals, consortium members performed systems analyses of NextGen concepts and airspace scenarios, and concurrently evaluated SA, workload, and performance measures to assess their appropriateness for evaluations of NextGen concepts and tools. The following activities and accomplishments were supported by the NRA: a distributed simulation, metric development, systems analysis, part-task simulations, and large-scale simulations. As a result of this NRA, we have gained a greater understanding of situation awareness and its measurement, and have shared our knowledge with the scientific community. This network provides a mechanism for consortium members, colleagues, and students to pursue research on other topics in air traffic management and aviation, thus enabling them to make greater contributions to the fiel

1,3-Benzothia­zole-2(3H)-selone

The title compound, C7H5NSSe, is the product of the reaction of 2-chloro­benzothia­zole with sodium hydro­selenide. The mol­ecule is almost planar (r.m.s. deviation = 0.018 Å) owing to the presence of the long chain of conjugated bonds (Se=C—N—C=C—C=C—C=C). The geometrical parameters correspond well to those of the analog N-methyl­benzothia­zole-2(3H)-selone, demonstrating that the S atom does not take a significant role in the electron delocalization within the mol­ecule. In the crystal, mol­ecules form centrosymmetric dimers by means of inter­molecular N—H⋯Se hydrogen bonds. The dimers have a nonplanar ladder-like structure. Furthermore, the dimers are linked into ribbons propagating in [010] by weak attractive Se⋯S [3.7593 (4) Å] inter­actions

Look into my eyes: pupillometry reveals that a post-hypnotic suggestion for word blindness reduces Stroop interference by marshalling greater effortful control

The mechanisms underpinning the apparently remarkable levels of cognitive and behavioural control following hypnosis and hypnotic suggestion are poorly understood. Numerous independent studies have reported that Stroop interference can be reduced following a post‐hypnotic suggestion that asks participants to perceive words as if made up of characters from a foreign language. This effect indicates that frontal executive functions can be more potent than is generally accepted and has been described as resulting from top‐down control not normally voluntarily available. We employed eye tracking and pupillometry to investigate whether the effect results from voluntary visuo‐attentional strategies (subtly looking away from the word to prevent optimal word processing), reduced response conflict but not overall conflict, Stroop effects being pushed from response selection to response execution (response durations) or increased proactive effortful control given enhanced contextual motivation (as indexed via pupil dilation). We replicated the reduction of Stroop interference following the suggestion despite removing any trials on which eye movements were not consistent with optimal word processing. Our data were inconclusive with regards to conflict type affected by the suggestion in the latency data, although preserved semantic conflict was evident in the pupil data. There was also no evidence of Stroop effects on response durations. However, we show that baseline corrected pupil sizes were larger following the suggestion indicating the socio‐cognitive context and experimental demands motivate participants to marshal greater effortful control

Three dimensional structure directs T-cell epitope dominance associated with allergy

<p>Abstract</p> <p>Background</p> <p>CD4+ T-cell epitope immunodominance is not adequately explained by peptide selectivity in class II major histocompatibility proteins, but it has been correlated with adjacent segments of conformational flexibility in several antigens.</p> <p>Methods</p> <p>The published T-cell responses to two venom allergens and two aeroallergens were used to construct profiles of epitope dominance, which were correlated with the distribution of conformational flexibility, as measured by crystallographic B factors, solvent-accessible surface, COREX residue stability, and sequence entropy.</p> <p>Results</p> <p>Epitopes associated with allergy tended to be excluded from and lie adjacent to flexible segments of the allergen.</p> <p>Conclusion</p> <p>During the initiation of allergy, the N- and/or C-terminal ends of proteolytic processing intermediates were preferentially loaded into antigen presenting proteins for the priming of CD4+ T cells.</p

Evidence for Time-of-Day Dependent Effect of Neurotoxic Dorsomedial Hypothalamic Lesions on Food Anticipatory Circadian Rhythms in Rats

The dorsomedial hypothalamus (DMH) is a site of circadian clock gene and immediate early gene expression inducible by daytime restricted feeding schedules that entrain food anticipatory circadian rhythms in rats and mice. The role of the DMH in the expression of anticipatory rhythms has been evaluated using different lesion methods. Partial lesions created with the neurotoxin ibotenic acid (IBO) have been reported to attenuate food anticipatory rhythms, while complete lesions made with radiofrequency current leave anticipatory rhythms largely intact. We tested a hypothesis that the DMH and fibers of passage spared by IBO lesions play a time-of-day dependent role in the expression of food anticipatory rhythms. Rats received intra-DMH microinjections of IBO and activity and body temperature (Tb) rhythms were recorded by telemetry during ad-lib food access, total food deprivation and scheduled feeding, with food provided for 4-h/day for 20 days in the middle of the light period and then for 20 days late in the dark period. During ad-lib food access, rats with DMH lesions exhibited a lower amplitude and mean level of light-dark entrained activity and Tb rhythms. During the daytime feeding schedule, all rats exhibited food anticipatory activity and Tb rhythms that persisted during 2 days without food in constant dark. In some rats with partial or total DMH ablation, the magnitude of the anticipatory rhythm was weak relative to most intact rats. When mealtime was shifted to the late night, the magnitude of the food anticipatory activity rhythms in these cases was restored to levels characteristic of intact rats. These results confirm that rats can anticipate scheduled daytime or nighttime meals without the DMH. Improved anticipation at night suggests a modulatory role for the DMH in the expression of food anticipatory activity rhythms during the daily light period, when nocturnal rodents normally sleep