Condensed Surfaces of Magnetic Neutron Stars, Thermal Surface Emission, and Particle Acceleration Above Pulsar Polar Caps

For sufficiently strong magnetic fields and/or low temperatures, the neutron star surface may be in a condensed state with little gas or plasma above it. Such surface condensation can significantly affect the thermal emission from isolated neutron stars, and may lead to the formation of a charge-depleted acceleration zone ("vacuum gap") in the magnetosphere above the stellar polar cap. Using the latest results on the cohesive property of magnetic condensed matter, we quantitatively determine the conditions for surface condensation and vacuum gap formation in magnetic neutron stars. We find that condensation can occur if the thermal energy kT of the neutron star surface is less than about 8% of its cohesive energy Q_s, and that a vacuum gap can form if the neutron star's rotation axis and magnetic moment point in opposite directions and kT is less than about 4% of Q_s. Thus, vacuum gap accelerators may exist for some neutron stars. Motivated by this result, we also study the physics of pair cascades in the vacuum gap model for photon emission by accelerating electrons and positrons due to both curvature radiation and resonant/nonresonant inverse Compton scattering. Our calculations of the condition of cascade-induced vacuum breakdown and the related pulsar death line/boundary generalize previous works to the superstrong field regime. We find that inverse Compton scatterings do not produce a sufficient number of high energy photons in the gap and thus do not lead to pair cascades for most neutron star parameters. We discuss the implications of our results for the recent observations of neutron star thermal radiation as well as for the detection/non-detection of radio emission from high-B pulsars and magnetars.Comment: 25 pages, 11 figures. Minor changes. MNRAS in pres

On the Design of Secure and Fast Double Block Length Hash Functions

In this work the security of the rate-1 double block length hash functions, which based on a block cipher with a block length of n-bit and a key length of 2n-bit, is reconsidered. Counter-examples and new attacks are presented on this general class of double block length hash functions with rate 1, which disclose uncovered flaws in the necessary conditions given by Satoh et al. and Hirose. Preimage and second preimage attacks are presented on Hirose's two examples which were left as an open problem. Therefore, although all the rate-1 hash functions in this general class are failed to be optimally (second) preimage resistant, the necessary conditions are refined for ensuring this general class of the rate-1 hash functions to be optimally secure against the collision attack. In particular, two typical examples, which designed under the refined conditions, are proven to be indifferentiable from the random oracle in the ideal cipher model. The security results are extended to a new class of double block length hash functions with rate 1, where one block cipher used in the compression function has the key length is equal to the block length, while the other is doubled

Spatiotemporal Patterns and Predictability of Cyberattacks

Y.C.L. was supported by Air Force Office of Scientific Research (AFOSR) under grant no. FA9550-10-1-0083 and Army Research Office (ARO) under grant no. W911NF-14-1-0504. S.X. was supported by Army Research Office (ARO) under grant no. W911NF-13-1-0141. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Microstructural evolution in materials during thermal processing

Copyright © 2012 Joseph K. L. Lai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.This article is made available through the Brunel Open Access Publishing Fund

Radiative transitions of the helium atom in highly magnetized neutron star atmospheres

Recent observations of thermally emitting isolated neutron stars revealed spectral features that could be interpreted as radiative transitions of He in a magnetized neutron star atmosphere. We present Hartree-Fock calculations of the polarization-dependent photoionization cross sections of the He atom in strong magnetic fields ranging from 10^12 G to 10^14 G. Convenient fitting formulae for the cross sections are given as well as related oscillator strengths for various bound-bound transitions. The effects of finite nucleus mass on the radiative absorption cross sections are examined using perturbation theory.Comment: 14 pages, 7 figures. Minor changes. MNRAS in pres

Human African trypanosomiasis : the current situation in endemic regions and the risks for non-endemic regions from imported cases

Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei gambiense and T. b. rhodesiense and caused devastating epidemics during the 20th century. Due to effective control programs implemented in the last two decades, the number of reported cases has fallen to a historically low level. Although fewer than 977 cases were reported in 2018 in endemic countries, HAT is still a public health problem in endemic regions until it is completely eliminated. In addition, almost 150 confirmed HAT cases were reported in non-endemic countries in the last three decades. The majority of non-endemic HAT cases were reported in Europe, United States and South Africa, due to historical alliances, economic links or geographic proximity to disease endemic countries. Furthermore, with the implementation of the “Belt and Road” project, sporadic imported HAT cases have been reported in China as a warning sign of tropical diseases prevention. In this paper, we explore and interpret the data on HAT incidence and find no positive correlation between the number of HAT cases from endemic and non-endemic countries.This data will provide useful information for better understanding the imported cases of HAT globally in the post-elimination phase

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei

BACKGROUND Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles. Beyond its role in pH maintenance, the involvement of V-ATPase in endocytosis is well documented in mammals and plants but is less clear in Trypanosoma brucei. METHODS In this study, the subcellular localization of V-ATPase subunit B (TbVAB) of T. brucei was assessed via in situ N-terminal YFP-tagging and immunofluorescence assays. Transgenic bloodstream forms (BSF) of T. brucei were generated which comprised either a V-ATPase subunit B (TbVAB) conditional knockout or a V-ATPase subunit A (TbVAA) knockdown. Acridine orange and BCECF-AM were employed to assess the roles of V-ATPase in the pH regulation of BSF T. brucei. The endocytic activities of three markers were also characterized by flow cytometry analyses. Furthermore, trypanosomes were counted from trypanolysis treatment groups (either containing 1% or 5% NHS) and endocytosed trypanosome lytic factor (TLF) was also analyzed by an immunoblotting assay. RESULTS TbVAB was found to localize to acidocalcisomes, lysosomes and probably also to endosomes of BSF of T. brucei and was demonstrated to be essential for cell growth. TbVAB depletion neutralized acidic organelles at 24 hours post-tetracycline depletion (hpd), meanwhile the steady state intracellular pH increased from 7.016 ± 0.013 to 7.422 ± 0.058. Trypanosomes with TbVAB depletion at 24 hpd were found to take up more transferrin (2.068 ± 0.277 fold) but less tomato lectin (49.31 ± 22.57%) by endocytosis, while no significant change was detected in dextran uptake. Similar endocytic dysregulated phenotypes were also observed in TbVAA knockdown cells. In addition, TbVAB depleted trypanosomes showed a low uptake of TLF and exhibited less sensitive to lysis in both 1% and 5% NHS treatments. CONCLUSIONS TbVAB is a key component of V-ATPase and was found to play a key function in endocytosis as well as exhibiting different effects in a receptor/cargo dependent manner in BSF of T. brucei. Besides vacuolar alkalinization, the dysregulation of endocytosis in TbVAB depleted T. brucei is considered to contribute to the reduced sensitivity to lysis by normal human serum

Beta-blockers and physical frailty in patients with end-stage liver disease.

AimTo investigate beta-blocker (BB) use in patients with cirrhosis and determine their effects on physical frailty and overall survival.MethodsAdult outpatients with cirrhosis listed for liver transplantation underwent testing of physical frailty using the performance-based Liver Frailty Index, comprised of chair stands, grip strength, and balance testing, as well as self-reported assessments of exhaustion and physical activity. BB use was assessed from medical chart review. Univariable and multivariable logistic regression were performed to determine BB use and their association with measures of physical frailty. Competing risk analyses were performed to determine the effect of BB use on wait-list mortality, as defined by death or delisting for being too sick for transplant.ResultsOf 344 patients, 35% were female, median age was 60, median model for end stage liver disease was 15, and 53% were prescribed a BB. Compared to those not on BB, patients on BB were similar except for percentage female (25% vs 46%; P < 0.001) and BMI (29 vs 28; P = 0.008). With respect to tests of physical frailty, BB use was not associated with increased odds of frailty (by the Liver Frailty Index), exhaustion, or low physical activity. BB use was, however, significantly associated with a decreased adjusted risk of mortality (SHR 0.55; P = 0.005).ConclusionIn patients with cirrhosis awaiting liver transplantation, BB use is not associated with physical frailty. We confirmed the known survival benefits with BB use, and concerns about adverse effects should not deter their utilization when indicated