Role of nuclear lamins in the regulation of SIRT6

Student Oral Presentation Session 1Sirtuins are a family of proteins which have been involved in a multitude of biological functions, especially longevity expansion. SIRT6 is a mammalian sirtuin with emerging functions in a spectrum of cellular events, such as cellular senescence, premature aging, DNA damage response, metabolism, extending lifespan and also tumor suppression. Although SIRT6 has been established to regulate a range of cellular functioning, its upstream regulation has remained elusive till date. Given its crucial roles in so many vital processes, identification of its ...postprin

SIRTain regulators of premature senescence and accelerated aging.

The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic homeostasis, safeguarding genomic integrity, regulating cancer metabolism and also inflammatory responses. Amongst the seven known mammalian sirtuin proteins, SIRT1 has gained much attention due to its widely acknowledged roles in promoting longevity and ameliorating age-associated pathologies. The contributions of other sirtuins in the field of aging are also gradually emerging. Here, we summarize some of the recent discoveries in sirtuins biology which clearly implicate the functions of sirtuin proteins in the regulation of premature cellular senescence and accelerated aging. The roles of sirtuins in various cellular processes have been extrapolated to draw inter-linkage with anti-aging mechanisms. Also, the latest findings on sirtuins which might have potential effects in the process of aging have been reviewed.published_or_final_versio

Anisotropic elasticity in confocal studies of colloidal crystals

We consider the theory of fluctuations of a colloidal solid observed in a confocal slice. For a cubic crystal we study the evolution of the projected elastic properties as a function of the anisotropy of the crystal using numerical methods based on the fast Fourier transform. In certain situations of high symmetry we find exact analytic results for the projected fluctuations.Comment: 6 pages, 7 figure

Realistic Anomaly Mediation with Bulk Gauge Fields

We present a simple general framework for realistic models of supersymmetry breaking driven by anomaly mediation. We consider a 5-dimensional "brane universe" where the visible and hidden sectors are localized on different branes, and the standard model gauge bosons propagate in the bulk. In this framework there can be charged scalar messengers that have contact interactions with the hidden sector, either localized in the hidden sector or in the bulk. These scalars obtain soft masses that feed into visible sector scalar masses at two loop order via bulk gauge interactions. This contribution is automatically flavor-blind, and can be naturally positive. If the messengers are in the bulk this contribution is automatically the same order of magnitude as the anomaly mediated contribution, independent of the brane spacing. If the messengers are localized to a brane the two effects are of the same order for relatively small brane spacings. The gaugino masses and A terms are determined completely by anomaly mediation. In order for anomaly mediation to dominate over radion mediation the radion must be is stabilized in a manner that preserves supersymmetry, with supergravity effects included. We show that this occurs in simple models. We also show that the mu problem can be solved by the vacuum expectation value of a singlet in this framework.Comment: 16 pages, LaTeX2e, no figure

The Evolution of Λ\Lambda Black Holes in the Mini-Superspace Approximation of Loop Quantum Gravity

Using the improved quantization technique to the mini-superspace approximation of loop quantum gravity, we study the evolution of black holes supported by a cosmological constant. The addition of a cosmological constant allows for classical solutions with planar, cylindrical, toroidal and higher genus black holes. Here we study the quantum analog of these space-times. In all scenarios studied, the singularity present in the classical counter-part is avoided in the quantized version and is replaced by a bounce, and in the late evolution, a series of less severe bounces. Interestingly, although there are differences during the evolution between the various symmetries and topologies, the evolution on the other side of the bounce asymptotes to space-times of Nariai-type, with the exception of the planar black hole analyzed here, whose $T$-$R$=constant subspaces seem to continue expanding in the long term evolution. For the other cases, Nariai-type universes are attractors in the quantum evolution, albeit with different parameters. We study here the quantum evolution of each symmetry in detail.Comment: 26 pages, 7 figures.V2 has typos corrected, references added, and a more careful analysis of the planar case. Accepted for publication in Physical Review

Investigation of Prediction Accuracy, Sensitivity, and Parameter Stability of Large-Scale Propagation Path Loss Models for 5G Wireless Communications

This paper compares three candidate large-scale propagation path loss models for use over the entire microwave and millimeter-wave (mmWave) radio spectrum: the alpha-beta-gamma (ABG) model, the close-in (CI) free space reference distance model, and the CI model with a frequency-weighted path loss exponent (CIF). Each of these models have been recently studied for use in standards bodies such as 3GPP, and for use in the design of fifth generation (5G) wireless systems in urban macrocell, urban microcell, and indoor office and shopping mall scenarios. Here we compare the accuracy and sensitivity of these models using measured data from 30 propagation measurement datasets from 2 GHz to 73 GHz over distances ranging from 4 m to 1238 m. A series of sensitivity analyses of the three models show that the physically-based two-parameter CI model and three-parameter CIF model offer computational simplicity, have very similar goodness of fit (i.e., the shadow fading standard deviation), exhibit more stable model parameter behavior across frequencies and distances, and yield smaller prediction error in sensitivity testing across distances and frequencies, when compared to the four-parameter ABG model. Results show the CI model with a 1 m close-in reference distance is suitable for outdoor environments, while the CIF model is more appropriate for indoor modeling. The CI and CIF models are easily implemented in existing 3GPP models by making a very subtle modification -- by replacing a floating non-physically based constant with a frequency-dependent constant that represents free space path loss in the first meter of propagation.Comment: Open access available at: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=743465

Heisenberg antiferromagnet on Cayley trees: low-energy spectrum and even/odd site imbalance

To understand the role of local sublattice imbalance in low-energy spectra of s=1/2 quantum antiferromagnets, we study the s=1/2 quantum nearest neighbor Heisenberg antiferromagnet on the coordination 3 Cayley tree. We perform many-body calculations using an implementation of the density matrix renormalization group (DMRG) technique for generic tree graphs. We discover that the bond-centered Cayley tree has a quasidegenerate set of a low-lying tower of states and an "anomalous" singlet-triplet finite-size gap scaling. For understanding the construction of the first excited state from the many-body ground state, we consider a wave function ansatz given by the single-mode approximation, which yields a high overlap with the DMRG wave function. Observing the ground-state entanglement spectrum leads us to a picture of the low-energy degrees of freedom being "giant spins" arising out of sublattice imbalance, which helps us analytically understand the scaling of the finite-size spin gap. The Schwinger-boson mean-field theory has been generalized to nonuniform lattices, and ground states have been found which are spatially inhomogeneous in the mean-field parameters.Comment: 19 pages, 12 figures, 6 tables. Changes made to manuscript after referee suggestions: parts reorganized, clarified discussion on Fibonacci tree, typos correcte

Study of parameter degeneracy and hierarchy sensitivity of NO ν A in presence of sterile neutrino

The first hint of the neutrino mass hierarchy is believed to come from the long-baseline experiment NOνA. Recent results from NOνA shows a mild preference towards the CP phase δ13 ¼ −90° and normal hierarchy. Fortunately this is the favorable area of the parameter space which does not suffer from the hierarchy-δ13 degeneracy and thus NOνA can have good hierarchy sensitivity for this true combination of hierarchy and δ13. Apart from the hierarchy-δ13 degeneracy there is also the octant-δ13 degeneracy. But this does not affect the favorable parameter space of NOνA as this degeneracy can be resolved with a balanced neutrino and antineutrino run. However, if we consider the existence of a light sterile neutrino then there may be additional degeneracies which can spoil the hierarchy sensitivity of NOνA even in the favorable parameter space. In the present work we find that apart from the degeneracies mentioned above, there are additional hierarchy and octant degeneracies that appear with the new phase δ14 in the presence of a light sterile neutrino in the eV scale. In contrast to the hierarchy and octant degeneracies appearing with δ13, the parameter space for hierarchy-δ14 degeneracy is different in neutrinos and antineutrinos though the octant- δ14 degeneracy behaves similarly in neutrinos and antineutrinos. We study the effect of these degeneracies on the hierarchy sensitivity of NOνA for the true normal hierarchy.Monojit Ghosh, Shivani Gupta, Zachary M. Matthews, Pankaj Sharma, and Anthony G. William

Solving relativistic hydrodynamic equation in presence of magnetic field for phase transition in a neutron star

Hadronic to quark matter phase transition may occur inside neutron stars (NS) having central densities of the order of 3-10 times normal nuclear matter saturation density ($n_0$). The transition is expected to be a two-step process; transition from hadronic to 2-flavour matter and two-flavour to $\beta$ equilibrated charge neutral three-flavour matter. In this paper we concentrate on the first step process and solve the relativistic hydrodynamic equations for the conversion front in presence of high magnetic field. Lorentz force due to magnetic field is included in the energy momentum tensor by averaging over the polar angles. We find that for an initial dipole configuration of the magnetic field with a sufficiently high value at the surface, velocity of the front increases considerably.Comment: 16 pages, 4 figures, same as published version of JPG, J. Phys. G: Nucl. Part. Phys. 39 (2012) 09520

Sub-Dominant Pairing Channels in Unconventional Superconductors: Ginzburg-Landau Theory

A Ginzburg-Landau theory is developed for unconventional superconductors with the three relevant singlet pairing channels. Various consequences of the sub-dominant channels (i.e., s- and d_{xy}-channels) are examined in detail. (1) In the case of a d_{x^2-y^2}+is-wave superconductor, The structure of a single vortex above and below T_{DS} is four-fold and two-fold symmetric, respectively. (2) In the case of a d_{x^2-y^2}+id_{xy}-wave superconductor, there is also a second order zero-field phase transition from the pure d_{x^2-y^2}-phase to the Time-reversal-symmetry-breaking d_{x^2-y^2}+id_{xy}-wave phase at the temperature T_{DD'}. But the subdominant phase can (not) be induced by vortices above T_{DD'}. Below the time-reversal- symmetry-breaking transition, the sub-dominant phase in the mixed state is nontrivial: it survives at low fields, but may disappear above a field (increasing with decreasing temperature) presumably via a first-order transition. (3)By including the strong coupling effects, a time-reversal-symmetry -breaking coupling term between the d_{x^2-y^2}- and d_{xy}-waves is found to have significant effects on the low temperature behavior of d_{x^2-y^2}+id_{xy} superconductors. In a magnetic field, a d_{x^2-y^2}+id_{xy} state is always established, but the field-dependence of d_{xy}-amplitude above T_{DD'} is different from that below T_{DD'}. Above but not very close to T_{DD'}, the induced minimum gap Delta_0 proportional to B/(T-T_{DD'}).Comment: updated, 7 two-column pages with one embedded figure, one formula corrected, to appear in Phys. Rev. B 6