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SURROGATE MARKERS IN ANIMAL MODELS OF ACQUIRED EPILEPSY: THE GOOD, THE BAD AND THE UGLY
Long-term effects of reduced renal mass in humans
Long-term effects of reduced renal mass in humans. The long-term risks of kidney donation have not been well defined. We carried out a meta-analysis of investigations that examined the long-term effects of reduced renal mass in humans. We used multiple linear regression to combine studies and adjust for differences in the duration of follow-up, the reason for reduced renal mass, the type of controls, age and gender. We analyzed 48 studies with 3124 patients and 1703 controls. Unilateral nephrectomy caused a decrement in glomerular filtration rate (-17.1 ml/min; 95% confidence interval -20.2 to -14.0 ml/min) that tended to improve with each 10 years of follow-up (1.4 ml/min/decade; 0.3 to 2.4 ml/min/decade). Patients with single kidneys had small, progressive increases in proteinuria (76 mg/day/decade; 52 to 101 mg/day/decade), but proteinuria was negligible after nephrectomy for trauma or kidney donation. Nephrectomy did not affect the prevalence of hypertension, but there was a small increase in systolic blood pressure (2.4 mm Hg; -0.3 to 5.1 mm Hg, P > 0.05) which rose further with duration of follow-up (1.1 mm Hg/decade; 0.0 to 2.2 mm Hg/decade). Diastolic blood pressure was higher after nephrectomy (3.1 mm Hg; 1.8 to 4.4 mm Hg), but this increment did not change with duration of follow-up. Thus, in normal individuals, unilateral nephrectomy does not cause progressive renal dysfunction, but may be associated with a small increase in blood pressure
Experimental identification and validation of models in micro and macro plasticity
For micro-macro approaches to finite plasticity, one needs experimental results on both scales, the engineering scale (macro scale) and the crystal scale (micro scale). Since we know that a monocrystal behaves different from a crystallite embedded in a polycrystal, one is also interested in data obtained on the micro scale of a polycrystal. Such data is needed not only for the identification of the material parameters like hardening variables, but also for the validation of these models. In this paper, experiments on both scales and, in parallel, FEM-simulations are presented, in order to compare the results of both approaches. The specimens stem from a rolled sheet of the deep-drawing steel DC04. On the micro scale indenter tests have been performed and the orientation changes in the volume below the indent have been measured using micron-resolution 3D x-ray microscopy (Larson et al., 2004, 2008). On the macro scale the usual tension tests and additional shear tests in different directions (Bouvier etal.,2006) have been performed. In corresponding simulations, the micro-macro transition is performed by a full constrained Taylor-model and, in order to overcome the drawbacks of the Taylor-model, the RVE technique has been applied
Impurity relaxation mechanism for dynamic magnetization reversal in a single domain grain
The interaction of coherent magnetization rotation with a system of two-level
impurities is studied. Two different, but not contradictory mechanisms, the
`slow-relaxing ion' and the `fast-relaxing ion' are utilized to derive a system
of integro-differential equations for the magnetization. In the case that the
impurity relaxation rate is much greater than the magnetization precession
frequency, these equations can be written in the form of the Landau-Lifshitz
equation with damping. Thus the damping parameter can be directly calculated
from these microscopic impurity relaxation processes
SU(2) WZW Theory at Higher Genera
We compute, by free field techniques, the scalar product of the SU(2)
Chern-Simons states on genus > 1 surfaces. The result is a finite-dimensional
integral over positions of ``screening charges'' and one complex modular
parameter. It uses an effective description of the CS states closely related to
the one worked out by Bertram. The scalar product formula allows to express the
higher genus partition functions of the WZW conformal field theory by
finite-dimensional integrals. It should provide the hermitian metric preserved
by the Knizhnik-Zamolodchikov-Bernard connection describing the variations of
the CS states under the change of the complex structure of the surface.Comment: 44 pages, IHES/P/94/10, Latex fil
Hysteresis and hierarchies: dynamics of disorder-driven first-order phase transformations
We use the zero-temperature random-field Ising model to study hysteretic
behavior at first-order phase transitions. Sweeping the external field through
zero, the model exhibits hysteresis, the return-point memory effect, and
avalanche fluctuations. There is a critical value of disorder at which a jump
in the magnetization (corresponding to an infinite avalanche) first occurs. We
study the universal behavior at this critical point using mean-field theory,
and also present preliminary results of numerical simulations in three
dimensions.Comment: 12 pages plus 2 appended figures, plain TeX, CU-MSC-747
Steps Toward Determination of the Size and Structure of the Broad-Line Region in Active Galactic Nuclei. XV. Long-Term Optical Monitoring of NGC 5548
We present the results of three years of ground-based observations of the
Seyfert 1 galaxy NGC 5548, which combined with previously reported data, yield
optical continuum and broad-line H-beta light curves for a total of eight
years. The light curves consist of over 800 points, with a typical spacing of a
few days between observations. During this eight-year period, the nuclear
continuum has varied by more than a factor of seven, and the H-beta emission
line has varied by a factor of nearly six. The H-beta emission line responds to
continuum variations with a time delay or lag of 10-20 days, the precise value
varying somewhat from year to year. We find some indications that the lag
varies with continuum flux in the sense that the lag is larger when the source
is brighter.Comment: 29 pages, 6 figures. Accepted for publication in ApJ (1999 Jan 10
High magnetic field scales and critical currents in SmFeAs(O,F) crystals: promising for applications
Superconducting technology provides most sensitive field detectors, promising
implementations of qubits and high field magnets for medical imaging and for
most powerful particle accelerators. Thus, with the discovery of new
superconducting materials, such as the iron pnictides, exploring their
potential for applications is one of the foremost tasks. Even if the critical
temperature Tc is high, intrinsic electronic properties might render
applications rather difficult, particularly if extreme electronic anisotropy
prevents effective pinning of vortices and thus severely limits the critical
current density, a problem well known for cuprates. While many questions
concerning microscopic electronic properties of the iron pnictides have been
successfully addressed and estimates point to a very high upper critical field,
their application potential is less clarified. Thus we focus here on the
critical currents, their anisotropy and the onset of electrical dissipation in
high magnetic fields up to 65 T. Our detailed study of the transport properties
of optimally doped SmFeAs(O,F) single crystals reveals a promising combination
of high (>2 x 10^6 A/cm^2) and nearly isotropic critical current densities
along all crystal directions. This favorable intragrain current transport in
SmFeAs(O,F), which shows the highest Tc of 54 K at ambient pressure, is a
crucial requirement for possible applications. Essential in these experiments
are 4-probe measurements on Focused Ion Beam (FIB) cut single crystals with
sub-\mu\m^2 cross-section, with current along and perpendicular to the
crystallographic c-axis and very good signal-to-noise ratio (SNR) in pulsed
magnetic fields. The pinning forces have been characterized by scaling the
magnetically measured "peak effect"
Lethal pneumatosis coli in a 12-month-old child caused by acute intestinal gas gangrene after prolonged artificial nutrition: a case report
<p>Abstract</p> <p>Introduction</p> <p>Pneumatosis coli is a rare disease with heterogeneous symptoms which can be detected in the course of various acute and chronic intestinal diseases in children, such as necrotizing enterocolitis, intestinal obstruction and intestinal bacteriological infections.</p> <p>Case presentation</p> <p>We report the case of a 12-month-old boy who died of pneumatosis coli caused by an acute intestinal gas gangrene after prolonged artificial alimentation.</p> <p>Conclusion</p> <p>While intestinal gas gangrene is a highly uncommon cause of pneumatosis coli, it is important to consider it as a differential diagnosis, especially in patients receiving a prolonged artificial food supply. These patients may develop intestinal gas gangrene due to a dysfunctional intestinal barrier.</p
Steps toward Determination of the Size and Structure of the Broad-Line Region in Active Galactic Nuclei. XII. Ground-Based Monitoring of 3C 390.3
Results of a ground-based optical monitoring campaign on 3C 390.3 in 1994-95
are presented. The broad-band fluxes (B, V, R, and I), the spectrophotometric
optical continuum flux F(5177) and the integrated emission-line fluxes of Ha,
Hb, Hg, HeI, and HeII all show a nearly monotonic increase with episodes of
milder short-term variations superposed. The amplitude of the continuum
variations increases with decreasing wavelength (4400-9000 A). The optical
continuum variations follow the variations in the ultraviolet and X-ray with
time delays, measured from the centroids of the cross- correlation functions,
typically around 5 days, but with uncertainties also typically around 5 days;
zero time delay between the high-energy and low-energy continuum variations
cannot be ruled out. The strong optical emission lines Ha, Hb, Hg, and HeI
respond to the high-energy continuum variations with time delays typically
about 20 days, with uncertainties of about 8 days. There is some evidence that
HeII responds somewhat more rapidly, with a time delay of around 10 days, but
again, the uncertainties are quite large (~8 days). The mean and rms spectra of
the Ha and Hb line profiles provide indications for the existence of at least
three distinct components located at +-4000 and 0 km/s relative to the line
peak. The emission-line profile variations are largest near line center.Comment: 42 pages (Latex), 13 figures, 14 table
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