First principles theory of fluctuations in vortex liquids and solids

Consistent perturbation theory for thermodynamical quantities in type II superconductors in magnetic field at low temperatures is developed. It is complementary to the existing expansion valid at high temperatures. Magnetization and specific heat are calculated to two loop order and compare well to existing Monte Carlo simulations and experiments.Comment: 3 .ps fig. In press Phys. Rev.

Charge 4e4e superconductivity from pair density wave order in certain high temperature superconductors

A number of spectacular experimental anomalies\cite{li-2007,fujita-2005} have recently been discovered in certain cuprates, notably {\LBCO} and {\LNSCO}, which exhibit unidirectional spin and charge order (known as ``stripe order''). We have recently proposed to interpret these observations as evidence for a novel ``striped superconducting'' state, in which the superconducting order parameter is modulated in space, such that its average is precisely zero. Here, we show that thermal melting of the striped superconducting state can lead to a number of unusual phases, of which the most novel is a charge $4e$ superconducting state, with a corresponding fractional flux quantum $hc/4e$. These are never-before observed states of matter, and ones, moreover, that cannot arise from the conventional Bardeen-Cooper-Schrieffer (BCS) mechanism. Thus, direct confirmation of their existence, even in a small subset of the cuprates, could have much broader implications for our understanding of high temperature superconductivity. We propose experiments to observe fractional flux quantization, which thereby could confirm the existence of these states.Comment: 5 pages, 2 figures; new version in Nature Physics format with a discussion of the effective Josephson coupling J2 and minor changes. Mildly edited abstract. v3: corrected versio

Isotropic Transverse XY Chain with Energy- and Magnetization Currents

The ground-state correlations are investigated for an isotropic transverse XY chain which is constrained to carry either a current of magnetization J_M or a current of energy J_E. We find that the effect of nonzero J_M on the large-distance decay of correlations is twofold: i) oscillations are introduced and ii) the amplitude of the power law decay increases with increasing current. The effect of energy current is more complex. Generically, correlations in current carrying states are found to decay faster than in the J_E=0 states, contrary to expectations that correlations are increased by the presence of currents. However, increasing the current, one reaches a special line where the correlations become comparable to those of the J_E=0 states. On this line, the symmetry of the ground state is enhanced and the transverse magnetization vanishes. Further increase of the current destroys the extra symmetry but the transverse magnetization remains at the high-symmetry, zero value.Comment: 7 pages, RevTex, 4 PostScript figure

Improved perturbation theory in the vortex liquids state of type II superconductors

We develop an optimized perturbation theory for the Ginzburg - Landau description of thermal fluctuations effects in the vortex liquids. Unlike the high temperature expansion which is asymptotic, the optimized expansion is convergent. Radius of convergence on the lowest Landau level is $a_{T}=-3$ in 2D and $a_{T}=-5$ in 3D. It allows a systematic calculation of magnetization and specific heat contributions due to thermal fluctuations of vortices in strongly type II superconductors to a very high precision. The results are in good agreement with existing Monte Carlo simulations and experiments. Limitations of various nonperturbative and phenomenological approaches are noted. In particular we show that there is no exact intersection point of the magnetization curves both in 2D and 3D.Comment: 24 pages, 9 figure

Opiates Transdeactivate Chemokine Receptors: δ and μ Opiate Receptor- Mediated Heterologous Desensitization

An intact chemotactic response is vital for leukocyte trafficking and host defense. Opiates are known to exert a number of immunomodulating effects in vitro and in vivo, and we sought to determine whether they were capable of inhibiting chemokine-induced directional migration of human leukocytes, and if so, to ascertain the mechanism involved. The endogenous opioid met- enkephalin induced monocyte chemotaxis in a pertussis toxin-sensitive manner. Metenkephalin, as well as morphine, inhibited IL-8-induced chemotaxis of human neutrophils and macrophage inflammatory protein (MIP)-1α, regulated upon activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein 1, but not MIP-1β-induced chemotaxis of human monocytes. This inhibition of chemotaxis was mediated by δ and μ but not κ G protein-coupled opiate receptors. Calcium flux induced by chemokines was unaffected by met-enkephalin pretreatment. Unlike other opiate-induced changes in leukocyte function, the inhibition of chemotaxis was not mediated by nitric oxide. Opiates induced phosphorylation of the chemokine receptors CXCR1 and CXCR2, but neither induced internalization of chemokine receptors nor perturbed chemokine binding. Thus, inhibition of chemokine-induced chemotaxis by opiates is due to heterologous desensitization through phosphorylation of chemokine receptors. This may contribute to the defects in host defense seen with opiate abuse and has important implications for immunomodulation induced by several endogenous neuropeptides which act through G protein-coupled receptors

Opportunities for integrated ecological analysis across inland Australia with standardised data from AusPlots Rangelands

Australian rangelands ecosystems cover 81% of the continent but are understudied and continental-scale research has been limited in part by a lack of precise data that are standardised between jurisdictions. We present a new dataset from AusPlots Rangelands that enables integrative rangelands analysis due to its geographic scope and standardised methodology. The method provides data on vegetation and soils, enabling comparison of a suite of metrics including fractional vegetation cover, basal area, and species richness, diversity, and composition. Cover estimates are robust and repeatable, allowing comparisons among environments and detection of modest change. The 442 field plots presented here span a rainfall gradient of 129–1437 mm Mean annual precipitation with varying seasonality. Vegetation measurements include vouchered vascular plant species, growth form, basal area, height, cover and substrate type from 1010 point intercepts as well as systematically recorded absences, which are useful for predictive modelling and validation of remote sensing applications. Leaf and soil samples are sampled for downstream chemical and genomic analysis. We overview the sampling of vegetation parameters and environments, applying the data to the question of how species abundance distributions (SADs) vary over climatic gradients, a key question for the influence of environmental change on ecosystem processes. We found linear relationships between SAD shape and rainfall within grassland and shrubland communities, indicating more uneven abundance in deserts and suggesting relative abundance may shift as a consequence of climate change, resulting in altered diversity and ecosystem function. The standardised data of AusPlots enables such analyses at large spatial scales, and the testing of predictions through time with longitudinal sampling. In future, the AusPlots field program will be directed towards improving coverage of space, under-represented environments, vegetation types and fauna and, increasingly, re-sampling of established plots. Providing up-to-date data access methods to enhance re-use is also a priority.Greg R. Guerin, Ben Sparrow, Andrew Tokmakoff, Anita Smyth, Emrys Leitch, Zdravko Baruch, Andrew J. Low

Role of electrostatic interactions in PDZ domain ligand recognition

ABSTRACT: PDZ domains are protein-protein interaction modules that normally recognize short C-terminal peptides. The apparent requirement for a ligand with a free terminal carboxylate group has led to the proposal that electrostatic interactions with the terminus play a significant role in recognition. However, this model has been called into question by the more recent finding that PDZ domains can recognize some internal peptide motifs that occur within a specific secondary structure context. Although these motifs bind at the same interface, they lack a terminal charge. Here we have investigated the role of electrostatics in PDZ-mediated recognition in the mouse R1-syntrophin PDZ domain by examining the salt dependence of binding to both terminal and internal ligands and the effects of mutating a conserved basic residue previously proposed to play a role in electrostatic recognition. These studies indicate that direct electrostatic interactions with the peptide terminus do not play a significant energetic role in binding. Additional chemical modification studies of the peptide terminus support a model in which steric and hydrogen bonding complementarity play a primary role in recognition specificity. Peptides with a free carboxy terminus, or presented within a specific structural context, can satisfy these requirements. Cells rely on modular protein-protein recognition domains to assemble multiprotein signaling complexes. PDZ 1 (PSD-95, Dlg, ZO-1 homology) domains form a large family of such modules. PDZ domain-containing proteins play an important role in organizing signaling structures at cellcell signaling junctions such as synapses (1, 2). PDZ domains were first characterized for their ability to specifically recognize C-terminal peptide ligands, including the C-termini of receptors and channels Here we describe experiments aimed at more precisely evaluating the role of electrostatic interactions in PDZmediated peptide recognition using the Mus musculus R1-syntrophin PDZ domain as a model system. First, we have determined the sensitivity of various PDZ-mediated interactions to ionic strength, and second, we have determined the effects of mutating a conserved basic residue in the PDZ binding groove that has been proposed to play a role in electrostatic recognition. These results indicate that electrostatics do not play a significant role in recognition of the terminal carboxylate. In addition, we have examined a library of ligand variants and found that PDZ domains discriminate very tightly between ligands with minor alterations in the precise chemical structure of the C-terminus. Together, these results are consistent with a model in which steric and † This research was supported by grants from the National Institutes of Health and the David and Lucille Packard Foundation (to W.A.L.) and the Stewart Trust (to R.K.G. alcohol; Fmoc, 9-fluorenylmethoxycarbonyl; FPLC, fast performance liquid chromatography; HATU, 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; HBTU, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; HEPES, N-(2-hydroxyethyl)piperazine-N′-2-ethanesulfonic acid; HPLC, high-pressure liquid chromatography; IPTG, isopropyl -D-thiogalactopyranoside; MeOH, methanol or methyl alcohol; Ni-NTA, nickel nitriloacetic acid; nNOS, neuronal nitric oxide synthase; PCR, polymerase chain reaction; PDZ, PSD-95, Dlg, ZO-1 homology; TEV, tobacco etch virus; TFA, trifluoroacetic acid; TIS, triisopropylsilane