16,235 research outputs found

    How to write a compelling (materials) science paper

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    Public vs private administration of rural health insurance schemes: a comparative study in Zhejiang of China.

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    : Since 2003, China has experimented in some of the country's counties with the private administration of the New Cooperative Medical Scheme (NCMS), a publicly subsidized health insurance scheme for rural populations. Our study compared the effectiveness and efficiency of private vs public administration in four counties in one of China's most affluent provinces in the initial stage of the NCMS's implementation. The study was undertaken in Ningbo city of Zhejiang province. Out of 10 counties in Ningbo, two counties with private administration for the NCMS (Beilun and Ninghai) were compared with two others counties with public administration (Zhenhai and Fenghua), using the following indicators: (1) proportion of enrollees who were compensated for inpatient care; (2) average reimbursement-expense ratio per episode of inpatient care; (3) overall administration cost; (4) enrollee satisfaction. Data from 2004 to 2006 were collected from the local health authorities, hospitals and the contracted insurance companies, supplemented by a randomized household questionnaire survey covering 176 households and 479 household members. In our sample counties, private administration of the NCMS neither reduced transaction costs, nor improved the benefits of enrollees. Enrollees covered by the publicly administered NCMS were more likely to be satisfied with the insurance scheme than those covered by the privately administered NCMS. Experience in the selected counties suggests that private administration of the NCMS did not deliver the hoped-for results. We conclude that caution needs to be exercised in extending private administration of the NCMS

    Delay-dependent robust stability of stochastic delay systems with Markovian switching

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    In recent years, stability of hybrid stochastic delay systems, one of the important issues in the study of stochastic systems, has received considerable attention. However, the existing results do not deal with the structure of the diffusion but estimate its upper bound, which induces conservatism. This paper studies delay-dependent robust stability of hybrid stochastic delay systems. A delay-dependent criterion for robust exponential stability of hybrid stochastic delay systems is presented in terms of linear matrix inequalities (LMIs), which exploits the structure of the diffusion. Numerical examples are given to verify the effectiveness and less conservativeness of the proposed method

    Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.

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    BACKGROUND: Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines in TBEV-mediated neurological disease are poorly understood. METHODS: BALB/c mice were intracerebrally injected with TBEV, followed by evaluation of chemokine and cytokine profiles using protein array analysis. The virus-infected mice were treated with the CC chemokine antagonist Met-RANTES or anti-RANTES mAb to determine the role of RANTES in affecting TBEV-induced neurological disease. The underlying signaling mechanisms were delineated using RANTES promoter luciferase reporter assay, siRNA-mediated knockdown, and pharmacological inhibitors in human brain-derived cell culture models. RESULTS: In a mouse model, pathological features including marked inflammatory cell infiltrates were observed in brain sections, which correlated with a robust up-regulation of RANTES within the brain but not in peripheral tissues and sera. Antagonizing RANTES within CNS extended the survival of mice and reduced accumulation of infiltrating cells in the brain after TBEV infection. Through in vitro studies, we show that virus infection up-regulated RANTES production at both mRNA and protein levels in human brain-derived cell lines and primary progenitor-derived astrocytes. Furthermore, IRF-3 pathway appeared to be essential for TBEV-induced RANTES production. Site mutation of an IRF-3-binding motif abrogated the RANTES promoter activity in virus-infected brain cells. Moreover, IRF-3 was activated upon TBEV infection as evidenced by phosphorylation of TBK1 and IRF-3, while blockade of IRF-3 activation drastically reduced virus-induced RANTES expression. CONCLUSIONS: Our findings together provide insights into the molecular mechanism underlying RANTES production induced by TBEV, highlighting its potential importance in the process of neuroinflammatory responses to TBEV infection

    Calorimetric Evidence of Strong-Coupling Multiband Superconductivity in Fe(Te0.57Se0.43) Single Crystal

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    We have investigated the specific heat of optimally-doped iron chalcogenide superconductor Fe(Te0.57Se0.43) with a high-quality single crystal sample. The electronic specific heat Ce of this sample has been successfully separated from the phonon contribution using the specific heat of a non-superconducting sample (Fe0.90Cu0.10)(Te0.57Se0.43) as a reference. The normal state Sommerfeld coefficient gamma_n of the superconducting sample is found to be ~ 26.6 mJ/mol K^2, indicating intermediate electronic correlation. The temperature dependence of Ce in the superconducting state can be best fitted using a double-gap model with 2Delta_s(0)/kBTc = 3.92 and 2Delta_l(0)/kBTc = 5.84. The large gap magnitudes derived from fitting, as well as the large specific heat jump of Delta_Ce(Tc)/gamma_n*Tc ~ 2.11, indicate strong-coupling superconductivity. Furthermore, the magnetic field dependence of specific heat shows strong evidence for multiband superconductivity

    Design and performance analysis of network code division multiplexing for wireless sensor networks

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    © 2015 IEEE. In this paper, we investigate the performance of a wireless sensor network, in which multiple groups of source nodes communicate with their respective destination nodes with the help of a common relay network. A network code division multiplexing (NCDM) scheme is proposed to remove the inter-session interference among multiple transmission sessions at each destination. We focus on analyzing the soft processing algorithm of the NCDM scheme. Based on the analysis results, a new code design criteria for the construction of the generator matrix is proposed. Simulation results show that by following the proposed code design criteria, the bit error ratio (BER) performance gap between the scheme we studied and the serial session scheme can be managed effectively. In serial session scheme, source nodes in a number of groups communicate with their respective destinations in a time division manner

    Analysing the Security of Google's implementation of OpenID Connect

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    Many millions of users routinely use their Google accounts to log in to relying party (RP) websites supporting the Google OpenID Connect service. OpenID Connect, a newly standardised single-sign-on protocol, builds an identity layer on top of the OAuth 2.0 protocol, which has itself been widely adopted to support identity management services. It adds identity management functionality to the OAuth 2.0 system and allows an RP to obtain assurances regarding the authenticity of an end user. A number of authors have analysed the security of the OAuth 2.0 protocol, but whether OpenID Connect is secure in practice remains an open question. We report on a large-scale practical study of Google's implementation of OpenID Connect, involving forensic examination of 103 RP websites which support its use for sign-in. Our study reveals serious vulnerabilities of a number of types, all of which allow an attacker to log in to an RP website as a victim user. Further examination suggests that these vulnerabilities are caused by a combination of Google's design of its OpenID Connect service and RP developers making design decisions which sacrifice security for simplicity of implementation. We also give practical recommendations for both RPs and OPs to help improve the security of real world OpenID Connect systems

    Network coded non-binary LDGM codes based on lattices for a multi-access relay system

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    © 2015 IEEE. In this paper, we propose a novel network coded non-binary low-density generator matrix (LDGM) code structure for a multi-access relay system, where multiple sources transmit lattice signals to a destination with the help of a relay. Specifically, we first develop a network coded non-binary LDGM code structure by jointly considering lattice-signal transmissions at the sources and the relay. Then we derive the achievable computation rate (ACR) for the proposed system and on that basis optimize the key parameters in the proposed structure to maximize the ACR. Furthermore, we optimize the network coded non-binary LDGM codes based on lattices to approach the ACR. Simulation results show that the optimal setting of the parameters is consistent with that obtained from our analysis and the proposed code structure outperforms the designed reference scheme
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